Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6.9e-07 0.024 14.8 0.1 28 86 36 97 24 118 0.70

2 3 1 3.4e+04 -14.5 42.5 430 485 111 163 99 171 0.65

3 3 9.6e-10 3.3e-05 24.3 1.0 327 381 252 307 243 320 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6.9e-07	0.024	14.8	0.1	28	86	36	97	24	118	0.70
2	3	1	3.4e+04	-14.5	42.5	430	485	111	163	99	171	0.65
3	3	9.6e-10	3.3e-05	24.3	1.0	327	381	252	307	243	320	0.89

Coding Sequence: ATGTCGGTCCAGGCGGAGCAGGCGGCGGCCCGAGGCGCGCCTGACACCAGGCACGGCCACCACCATCACGGCCATCACAACCACGGGCACCACGTCGAGCCGGATCCCGCCACTGCCTCGCTCTTCCGCGCCCCCGTCAAGGTGAATCCTGACGCCCACGACCGCACAACGCAGCAAATCCAGTCGAAGCTCGGAAAGTACTCGCTGGTGAAGCACCTACTGGACGAGCCGAAGAGCCTGATCGGCATCGAGGGAGTGCCAGCCTCGCCAGCGCCGGGCAATCCCGGCCACCCCCGGCTCCAGTCGATGAGCCGAAACTCGCCGTCTTCGTCGCAGGAGTTCAAGAAGCCCGGCGGGCCGCGCTCGTCTTCCGCGGCCGCCTCCTCGAGCGCCGGCGCAGCCGCGAGCTCGTCGACCGGGCcagcttcctcctcctcctcctcctcctcttcctcctcctcgtcgtcctcgtcgagctCCTCGTCGCAGCGCGGCGGGTTCGTCAAGCCGGCGGACGGCAAGCTGCCGTATTCGAGCCGGGTCGGCTACCCGGGCCAGCTGAAGCACGCGGATCACCGCGGCAGCGCCGGCCACGGCCTCCTGCCCGGCAAGCCGCCCggctcgtcctcctcctcggccggCCAGAGCAGCGCCGCTGGAATGTCGGCCGGCGCCGGCGCGCCAACCTCCCAGTCCGGTATGCTCAACGGCGCCGGCCTCGGCTCCCAGAGCAGGCTCCACACCGTCAGCGGCAGGCTGCCCAAGCTGCCTATCGATACGGGACCGAGTTCCAGGCATCTTAGCGCAGACAGCACAGCCGAGGTGGAGACCATCTTGAAGGAAATGACCATGCCACCGACGCCTCTGACCGCCATCGCCCAGACGCCGAGAAAAGAATTGGAGTCCAAGTTCACCTTCAATCCAGTGCTCGCCAAGctcaCGGAAGTACCGTCCCAAGATGCTGTGAAGCCTCGTAAGTAG
Protein Sequence: MSVQAEQAAARGAPDTRHGHHHHGHHNHGHHVEPDPATASLFRAPVKVNPDAHDRTTQQIQSKLGKYSLVKHLLDEPKSLIGIEGVPASPAPGNPGHPRLQSMSRNSPSSSQEFKKPGGPRSSSAAASSSAGAAASSSTGPASSSSSSSSSSSSSSSSSSSSQRGGFVKPADGKLPYSSRVGYPGQLKHADHRGSAGHGLLPGKPPGSSSSSAGQSSAAGMSAGAGAPTSQSGMLNGAGLGSQSRLHTVSGRLPKLPIDTGPSSRHLSADSTAEVETILKEMTMPPTPLTAIAQTPRKELESKFTFNPVLAKLTEVPSQDAVKPRK

Sequence clustering based on sequence similarity using MMseqs2