g1215.t1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Amphipyra tragopoginis
Gene Symbol
foxj1_1
Assembly
GCA_905220435.1
Location
HG991994.1:4906787-4908244[-]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.3e-36 7.7e-34 114.6 0.4 1 84 173 254 173 258 0.94

Sequence Information

Coding Sequence
ATGCATATAACGTCAGGCCTATCTCCGGCGTCCGGGGAGATGCTGGACGCGACGTCGCTCAATTTTTATGGAGATGCTGGAGAGCAATGTGGGACTACGTACTTCGCTGTGGACCATATGGTTCCGGAGTCATCTCACACCGTCGAGATAGAGTACGTGTACGAGCAACCGGAAACCTACGCTATAAACCAAGACGATTTAGAAACGGATGTGGTTCAAAAAGAAACGGTCATCGCCCCAGATCACGATGATTACTCCAAAAAGATACGCAGCAAACACAAGCCCAACAAAATGGTTGTAGACGAAGAACCAGAGGCTGACTTAACGAACTTGACATGGCTGCAGAATATAACGAATATAATGTCGGTGCCGCAGTTTCCGATACCACCGATGTCGCCAAACCCGCAAGTGAAGACGCAGCCGCAGAACACGAGGCTGCAGAAGTTCAACCAGACGATAGCGAAGTGTCAGAAAGACTTTACGGAGAACAAGCACGAGTATCGGACGAACAATGAGAAGAAGCCTCCGTATTCGTACAGCACGTTGATCTGTATGGCGATGAGGTACAACAACGACAAGATGACGTTGTCCGCAATATATTCGTGGATCAGAGATAATTTCAAGTACTACAGGAATGCTGACCCTACCTGGCAGaattCCATACGGCACAACCTCTCCCTAAACAAAGTGTTTGTGAAAGTAGCTCGATCAAAACACGAGCCAGGAAAAGGGGGCTTCTGGAAGCTCGACCTCGCACATCTAGAAGGAACCAAACGAATCTCAAATAGACCTCACAAAAAGAAGAAAGCATCGTCAAAAGATAAGATCACAGAAGAAAAAACTGCAATCGCAAATATACCACAAATAAACGCAGTTGAAGATATTACTAACGAAATAAATCAGGCTGTGACACTGCACTTGCCAGATTTTAGTCTCGGCAGTATTCAGAGCCTTCCTGATATGGATTTGGAAACGAATATTGGAGCCAATGTGATTGTGGAACCAACTATACCACCTCCTTTGATCCCTGAAGATGATCTATCGTCCCTGCTTTTGAATCCAACGGATTGGGACGACCTGCAACTGGATATGTTGGATAATTACCTGGATTCTTGTTTCAAGTAA
Protein Sequence
MHITSGLSPASGEMLDATSLNFYGDAGEQCGTTYFAVDHMVPESSHTVEIEYVYEQPETYAINQDDLETDVVQKETVIAPDHDDYSKKIRSKHKPNKMVVDEEPEADLTNLTWLQNITNIMSVPQFPIPPMSPNPQVKTQPQNTRLQKFNQTIAKCQKDFTENKHEYRTNNEKKPPYSYSTLICMAMRYNNDKMTLSAIYSWIRDNFKYYRNADPTWQNSIRHNLSLNKVFVKVARSKHEPGKGGFWKLDLAHLEGTKRISNRPHKKKKASSKDKITEEKTAIANIPQINAVEDITNEINQAVTLHLPDFSLGSIQSLPDMDLETNIGANVIVEPTIPPPLIPEDDLSSLLLNPTDWDDLQLDMLDNYLDSCFK*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00783241;
90% Identity
iTF_00363842; iTF_00667170; iTF_00449936; iTF_00171573; iTF_00808920; iTF_01424861; iTF_00017996; iTF_01342034; iTF_00049715; iTF_01538553; iTF_01084065; iTF_01084953; iTF_00185954; iTF_00000131; iTF_00000997; iTF_00185125; iTF_01487527; iTF_00326900; iTF_01221309; iTF_00757954; iTF_00043298; iTF_00042445; iTF_00039608; iTF_00041593; iTF_00040608; iTF_00622626; iTF_00176922; iTF_00830981; iTF_00783241; iTF_00785831; iTF_00784208; iTF_00374991; iTF_00745441; iTF_00172546; iTF_00448835; iTF_01440803; iTF_00905928; iTF_00907694; iTF_00038511; iTF_01285360; iTF_01526832; iTF_01092881; iTF_00071218; iTF_00726099; iTF_01525747; iTF_00124053; iTF_00924405; iTF_00036439; iTF_00037591; iTF_00122171; iTF_00906875; iTF_00121212; iTF_00123165; iTF_00373725; iTF_01093853; iTF_01439710; iTF_01246640; iTF_00147115; iTF_00120304; iTF_01230325; iTF_00300983; iTF_01531778; iTF_00446931; iTF_00301914; iTF_00274264; iTF_00809875; iTF_00273429; iTF_01338302; iTF_01339773; iTF_00237280; iTF_01025795; iTF_00445923; iTF_00425188; iTF_01030948; iTF_00850408; iTF_01029032; iTF_01062568; iTF_01532842; iTF_01027115; iTF_01063563; iTF_00711628; iTF_00851532; iTF_01028079; iTF_01534610; iTF_01533748; iTF_01029973; iTF_01119093; iTF_01118070; iTF_00111417; iTF_00928473; iTF_01116986; iTF_00444923; iTF_00444924; iTF_00299967; iTF_00888031; iTF_00973535; iTF_01061695; iTF_01064448; iTF_00952517; iTF_00951608; iTF_00771690; iTF_00685245; iTF_00785016;
80% Identity
-