Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 9.3e-09 1.2e-05 26.2 0.1 14 49 2 37 1 38 0.87

2 4 3.8e-14 4.9e-11 43.5 0.2 2 49 78 125 77 130 0.91

3 4 3.8e-14 4.9e-11 43.5 0.2 2 49 166 213 165 218 0.91

4 4 2e-13 2.6e-10 41.2 0.2 2 49 254 301 253 302 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	9.3e-09	1.2e-05	26.2	0.1	14	49	2	37	1	38	0.87
2	4	3.8e-14	4.9e-11	43.5	0.2	2	49	78	125	77	130	0.91
3	4	3.8e-14	4.9e-11	43.5	0.2	2	49	166	213	165	218	0.91
4	4	2e-13	2.6e-10	41.2	0.2	2	49	254	301	253	302	0.91

Coding Sequence: ATGGGCATAGGGAGCAGTGAAGAAAAACATCTAACCCTTAGTAGCATCTATGATTGGATTGCCGAGACATTTCCGTATTATGAAACAGTGAAGTATAAGAGCTTACGGAATCAGGATATCTCTGAAAAAGCTGAAATCACCACATCTGCCGCAACTATATCAAATCAAGTATTTCAATCGAATCTATCATTCGATGAAAACGTGTCACCAGAAAGCAAATCACCTCATGGCAAGCATACATATAGCTACAGTGCCCTAATCATAATGGGCATAGGGAGCAGTGAAGAAAAACATCTAACCCTTAGTAGCATCTATGATTGGATTGCCGAGACATTTCCGTATTATGAAACAGTGAAGTATAAGAGCTTAAGGAATCAGGATATCTCTGAAATAGCTGAAATCACCAGATCTAACGCAACTATGTCAAATCAAGTATTTCAATCGAATCTATCATTCGATGAAAACGTGTCACCAGAAAGCAAATCACCTCATGGCAAGCATACATATAGCTACAGTGCCCTAATCATAATGGGCATAGGGAGCAGTGAAGAAAAACATCTAACCCTTAGTAGCATCTATGATTGGATTGCCGAGACATTTCCGTATTATGAAACAGTGAAGTATAAGAGCTTAAGGAATCAGGATATCTCTGAAATAGCTGAAATCACCACATCTAACGCAACTATGTCAAATCAAGTATTTCAATCGAATCTATCATTCGATGAAAACGTGTCACCAGAAAGCAAATCACCTCATGGCAAGCATACATATAGCTACAGTGCCCTTATCATAATGGGAGTAGGGAGCAGTGAAGAAAAACATCTAACCCTTAGTAGCATCTATGATTGGATTGCCGAGACATTTCCGTATTATGAAACAGTGAAGTATAAGAGCTTAAGGAATCAGGATATCTCTGAAATAGCTGAAATCACCACATCTAACGCAACTATGTCAAATTAA
Protein Sequence: MGIGSSEEKHLTLSSIYDWIAETFPYYETVKYKSLRNQDISEKAEITTSAATISNQVFQSNLSFDENVSPESKSPHGKHTYSYSALIIMGIGSSEEKHLTLSSIYDWIAETFPYYETVKYKSLRNQDISEIAEITRSNATMSNQVFQSNLSFDENVSPESKSPHGKHTYSYSALIIMGIGSSEEKHLTLSSIYDWIAETFPYYETVKYKSLRNQDISEIAEITTSNATMSNQVFQSNLSFDENVSPESKSPHGKHTYSYSALIIMGVGSSEEKHLTLSSIYDWIAETFPYYETVKYKSLRNQDISEIAEITTSNATMSN

Sequence clustering based on sequence similarity using MMseqs2