Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 2.3 1.8e+02 2.3 0.2 25 37 121 133 110 143 0.72

2 5 9.8 7.7e+02 0.3 0.1 25 44 151 170 142 174 0.81

3 5 0.003 0.24 11.5 1.0 20 48 174 202 167 206 0.83

4 5 0.0017 0.14 12.3 0.0 21 52 203 234 201 234 0.88

5 5 0.12 9.3 6.4 0.0 21 48 231 258 229 260 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	2.3	1.8e+02	2.3	0.2	25	37	121	133	110	143	0.72
2	5	9.8	7.7e+02	0.3	0.1	25	44	151	170	142	174	0.81
3	5	0.003	0.24	11.5	1.0	20	48	174	202	167	206	0.83
4	5	0.0017	0.14	12.3	0.0	21	52	203	234	201	234	0.88
5	5	0.12	9.3	6.4	0.0	21	48	231	258	229	260	0.89

Coding Sequence: ATGGAGGCTCGAGATGAAGATGATTTTCATCCATCTTTAGAACCAATGGTAATAATCAGTGATGGTGACTATACACCAGAGCAGGAATATGAAAACGATGATGAAGATCCTTTAGCAGGAAATAATTCAGATAATGAATTAATTAATTCAATTGGTCCTGAAATTTCAATTATAATGATAAAGAAAAAGAAGCCTTCGTTTAAAATAAAATTGTTTGAAAAAGAATATTCTCCATCTAAAGATGACCACTCAGCCAAAGTTCAGAGTATTACTAGGGCTCGAGAAAAAGTTCGATTAATAACTAAAGATGAAGCACTAAATGCAAAAGAAACATATGCTAAGCGTAGATCAAATCCTTTAGAAAAGTGCCCTATATGCAAGAAATTTTTTAGAAGGATGAAAACTCACCTGTTAAAACATAGTGTTTGTACAAAATCTCTCGAAGAACAGCTATTTTGTAATTTGTGCCAAAAAGTGTTTAACACCCAGAGTAATTTAGCCATTCACATGAGGAGCCACAATGGAGAGAGGCCTTACGTATGCGAAATTTGCAATAAATGTTTTTCCCAAAGTTGCAACTTAGTTAACCACATGCGAGTTCACACAGGTGAAAAACCGTTTAAGTGTCCTCACTGCGACAGGGCATTTACACAGTCTGGTAATTTAAACAACCATATTCGACTTCACACGGATGAAAAGCCTTTCAAATGTCATTTTTGTGAAAAAGCATTTGTACAATCGGGTAACCTTAATTCTCATATAAGGAACAATCACAAATATGTCGATGAAGCTGTTGCATTACCTTTATCAATGATGTAG
Protein Sequence: MEARDEDDFHPSLEPMVIISDGDYTPEQEYENDDEDPLAGNNSDNELINSIGPEISIIMIKKKKPSFKIKLFEKEYSPSKDDHSAKVQSITRAREKVRLITKDEALNAKETYAKRRSNPLEKCPICKKFFRRMKTHLLKHSVCTKSLEEQLFCNLCQKVFNTQSNLAIHMRSHNGERPYVCEICNKCFSQSCNLVNHMRVHTGEKPFKCPHCDRAFTQSGNLNNHIRLHTDEKPFKCHFCEKAFVQSGNLNSHIRNNHKYVDEAVALPLSMM

Sequence clustering based on sequence similarity using MMseqs2