Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.097 7.7 6.7 0.1 27 48 196 217 191 222 0.85

2 6 6.3 5e+02 0.9 0.1 23 44 220 241 216 246 0.86

3 6 0.002 0.16 12.1 0.1 21 51 246 276 242 277 0.87

4 6 0.067 5.3 7.2 0.0 21 52 274 305 270 307 0.87

5 6 7.6 6e+02 0.6 0.2 21 43 302 324 298 329 0.78

6 6 0.0069 0.55 10.4 0.2 20 44 329 353 320 359 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.097	7.7	6.7	0.1	27	48	196	217	191	222	0.85
2	6	6.3	5e+02	0.9	0.1	23	44	220	241	216	246	0.86
3	6	0.002	0.16	12.1	0.1	21	51	246	276	242	277	0.87
4	6	0.067	5.3	7.2	0.0	21	52	274	305	270	307	0.87
5	6	7.6	6e+02	0.6	0.2	21	43	302	324	298	329	0.78
6	6	0.0069	0.55	10.4	0.2	20	44	329	353	320	359	0.83

Coding Sequence: ATGGATAGTTTCAAAGAAGAATCAGATTCATTAATGAATAATACAATCGAAAGTAATCCTAAAGAACTGTTATCTAATTTTAAAACCGAAGAAATTGAAATTGAAGAATGTAAACCCGAATTCGAGAACTTGCATCAAATTGACTATTATATGATGAAACGGGAAAGTTCTGAAGAAAAAGTTTCTCTAACTAAAAGTGATGTTTTAATAAGCAAAGAAAATATAAAAACTGAAAATGTTTATTCAAATGAGAATATTCAAGAAATAAAAAGTGATATCGAAATTAAGAAATTTGATTTCCCTGTTTGTACAAAAGCTATCCATGATTTTGTTGAAGTAGGACAAACTGTGCAAACAATCAAAATGCATTCTACGATAAAATGTTTTCTGTCTGTGCCGAAAAAGTGGCAACCTCACTTTGGGAAATTTTATGGAACATGTTTCTCTTGTGGACAATTTTTCTGTGATAAATTGCTATTTTTAAACCATTTTTATATATACCACTTTTTAGATAATTCCAAAAAATCTGTTAGCTTAAGAAAGAATAATTCTGATAAAAAACATATTGGACAAATGTTCTTTAAATGCGAAATTTGTACAAAATGTTTCACACAATCCAGTGATTTACAAAGGCATACTAGAATTCACACTGACAAGAAACCTTTTCAATGTAAAATTTGTTCAAAATGTTTCACATATTCCAGTAGCTTAAAAATTCATATAAGAACTCACACTGGTGAAAAACCTTTTAGATGTGAAATTTGTTTAAAATGTTTCACACAATCAAGTAATTTAAATACGCATGTTAAAATTCACGATGGCGAGAAACCTTTTAAATGTGAAATTTGTTCAAAATGTTTCACAGCATTCAAAGACTTAAAAAGGCATGTTAGAATTCACACAGGTGAAAAACCTTATAAATGTGAGATTTGTTCAAAGAGTTTCTCACGAAAATGTGACTTAAAAAATCATAGTAGAATTCACACTGGCGAGAAACCTTATAAATGTGAAATTTGTTCAAAATGTTTCATAACATCAAGTAATTTAAAAAGGCATACTAGAACTCACACTGGTAAAACCTTACAGTTGTGA
Protein Sequence: MDSFKEESDSLMNNTIESNPKELLSNFKTEEIEIEECKPEFENLHQIDYYMMKRESSEEKVSLTKSDVLISKENIKTENVYSNENIQEIKSDIEIKKFDFPVCTKAIHDFVEVGQTVQTIKMHSTIKCFLSVPKKWQPHFGKFYGTCFSCGQFFCDKLLFLNHFYIYHFLDNSKKSVSLRKNNSDKKHIGQMFFKCEICTKCFTQSSDLQRHTRIHTDKKPFQCKICSKCFTYSSSLKIHIRTHTGEKPFRCEICLKCFTQSSNLNTHVKIHDGEKPFKCEICSKCFTAFKDLKRHVRIHTGEKPYKCEICSKSFSRKCDLKNHSRIHTGEKPYKCEICSKCFITSSNLKRHTRTHTGKTLQL

Sequence clustering based on sequence similarity using MMseqs2