Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.028 2.2 8.4 0.1 18 45 2 30 1 37 0.78

2 6 0.98 78 3.5 0.0 21 47 34 60 29 63 0.80

3 6 0.081 6.4 7.0 0.6 21 44 63 86 48 90 0.82

4 6 0.016 1.3 9.2 0.0 21 48 91 118 87 122 0.86

5 6 0.04 3.2 8.0 0.1 21 47 119 145 115 152 0.85

6 6 2.1 1.6e+02 2.5 0.1 21 44 147 170 143 178 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.028	2.2	8.4	0.1	18	45	2	30	1	37	0.78
2	6	0.98	78	3.5	0.0	21	47	34	60	29	63	0.80
3	6	0.081	6.4	7.0	0.6	21	44	63	86	48	90	0.82
4	6	0.016	1.3	9.2	0.0	21	48	91	118	87	122	0.86
5	6	0.04	3.2	8.0	0.1	21	47	119	145	115	152	0.85
6	6	2.1	1.6e+02	2.5	0.1	21	44	147	170	143	178	0.81

Coding Sequence: ATGAGGACACAGAGTGGACATAAATCCTTTAAATGCGAAATTTGTTCAAAATGTTTTTTACATTCCGGTAATTTAAAAAGGCATATTAGAAGTCACACTGGTGAAAAACCCTTCAGATGTGGAATTTGTTCAAAATATTTCACAGAAAAAAGTAGCTTAAAAGAGCATATTACTAGAACTCACACTGGTGAAAAACCTTTCAGATGTGAAATTTGTTCAAAATGTTTCATACGACAAAGGGATTTAAAACAGCATACCAGAATTCACACTGACGAAAAACCTTTTATGTGTAAAATTTGTTCAAAATGTTTCAGATTCTCCGGTGATTTAAAAATGCACATTAGAATTCACACTGACGAGAAACCTTTTAAATGTGAAATTTGTTCAAAATGCTTTATAGCATCCGGTCATTTAAAAAGGCATATTAGAACTCACACTGGTGAAAAACCTTTCATTTGTGAAATTTGTTCAAAATGTTTCACAGAAAAAGGTAGCTTAAAAGAGCATATTATTAGAATTCACACTGTTGAAAAGTCATTTAAATGTGAAAACTGTTCAAAATTTTTTCCACGAGAAAGTGATTTAAAACACCATATTAGAATTCATACTGACAAAAAAACCTTTTAA
Protein Sequence: MRTQSGHKSFKCEICSKCFLHSGNLKRHIRSHTGEKPFRCGICSKYFTEKSSLKEHITRTHTGEKPFRCEICSKCFIRQRDLKQHTRIHTDEKPFMCKICSKCFRFSGDLKMHIRIHTDEKPFKCEICSKCFIASGHLKRHIRTHTGEKPFICEICSKCFTEKGSLKEHIIRIHTVEKSFKCENCSKFFPRESDLKHHIRIHTDKKTF

Sequence clustering based on sequence similarity using MMseqs2