Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.04 3.2 8.0 0.1 18 45 2 30 1 37 0.78

2 8 1.4 1.1e+02 3.0 0.0 21 47 34 60 29 63 0.79

3 8 0.17 13 6.0 0.9 21 44 63 86 55 90 0.80

4 8 0.023 1.8 8.7 0.0 21 48 91 118 87 122 0.86

5 8 0.059 4.7 7.4 0.1 21 47 119 145 116 152 0.85

6 8 3 2.4e+02 2.0 0.1 21 44 147 170 143 177 0.81

7 8 1.4 1.1e+02 3.0 0.2 21 46 204 229 196 234 0.86

8 8 0.092 7.3 6.8 0.2 22 44 233 255 228 260 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.04	3.2	8.0	0.1	18	45	2	30	1	37	0.78
2	8	1.4	1.1e+02	3.0	0.0	21	47	34	60	29	63	0.79
3	8	0.17	13	6.0	0.9	21	44	63	86	55	90	0.80
4	8	0.023	1.8	8.7	0.0	21	48	91	118	87	122	0.86
5	8	0.059	4.7	7.4	0.1	21	47	119	145	116	152	0.85
6	8	3	2.4e+02	2.0	0.1	21	44	147	170	143	177	0.81
7	8	1.4	1.1e+02	3.0	0.2	21	46	204	229	196	234	0.86
8	8	0.092	7.3	6.8	0.2	22	44	233	255	228	260	0.88

Coding Sequence: ATGAGGACACAGAGTGGACATAAATCCTTTAAATGCGAAATTTGTTCAAAATGTTTTTTACATTCCGGTAATTTAAAAAGGCATATTAGAAGTCACACTGGTGAAAAACCTTTCAGATGTGGAATTTGTTCAAAATATTTCACAGAAAAAAGTAGCTTAAAAGAGCATATTACTAGAACTCACACTGGTGAAAAACCTTTCAGATGTGAAATTTGTTCAAAATGTTTCATACGACAAAGGGATTTAAAACAGCATACTAGAATTCACACTGACGAAAAACCTTTTATGTGTAAAATTTGTTCAAAATGTTTCAGATTCTCCGGTGATTTAAAAATGCACATTAGAATTCACACTGACGAGAAACCTTTTAAATGTGAAATTTGTTCAAAATGCTTTATAGCATCCGGTCATTTAAAAAGGCATATTAGAACTCACACTGGTGAAAAACCTTTCATTTGTGAAATTTGTTCAAAATGTTTCACAGAAAAAGGTAGCTTAAAAGAGCATATTATTAGAATTCACACTGTTGAAAAGTCATTTAAATGTGAAAACTGTTCAAAATTTTTTCCACGAGAAAGTGATTTAAAACACCATATTAGAATTCATACTGACGAAAAACCTTTTAAATGTGAAATCTGTTCAAAATGTTTCACACACTTGCATTCTTTAAAACAGCATATTAGAATTCACACTGACGAGAAATCTTTTAAATGTGAAATTTGTTCAAAATGTTTTAGAGGATCCAGTGTTTTAAAAAGGCATATTAGAACTCACACTGGTGAAAAAGCCTTTTAA
Protein Sequence: MRTQSGHKSFKCEICSKCFLHSGNLKRHIRSHTGEKPFRCGICSKYFTEKSSLKEHITRTHTGEKPFRCEICSKCFIRQRDLKQHTRIHTDEKPFMCKICSKCFRFSGDLKMHIRIHTDEKPFKCEICSKCFIASGHLKRHIRTHTGEKPFICEICSKCFTEKGSLKEHIIRIHTVEKSFKCENCSKFFPRESDLKHHIRIHTDEKPFKCEICSKCFTHLHSLKQHIRIHTDEKSFKCEICSKCFRGSSVLKRHIRTHTGEKAF

Sequence clustering based on sequence similarity using MMseqs2