Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00072 0.057 13.5 0.2 20 51 82 113 70 114 0.81

2 6 0.00045 0.035 14.2 0.2 21 48 111 138 108 142 0.87

3 6 0.0025 0.2 11.8 0.3 21 44 139 162 135 167 0.90

4 6 0.34 27 5.0 0.2 21 46 167 192 163 198 0.85

5 6 5.5 4.4e+02 1.1 0.1 21 37 195 211 191 223 0.73

6 6 0.065 5.1 7.3 0.0 21 45 223 247 215 252 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00072	0.057	13.5	0.2	20	51	82	113	70	114	0.81
2	6	0.00045	0.035	14.2	0.2	21	48	111	138	108	142	0.87
3	6	0.0025	0.2	11.8	0.3	21	44	139	162	135	167	0.90
4	6	0.34	27	5.0	0.2	21	46	167	192	163	198	0.85
5	6	5.5	4.4e+02	1.1	0.1	21	37	195	211	191	223	0.73
6	6	0.065	5.1	7.3	0.0	21	45	223	247	215	252	0.89

Coding Sequence: ATGGATATTTCTGTAATAAAGCAAGAAGAAATAGAAATAGAATCAAAATCAGCATGTTTTGATCAGAGAGAAATAATTGAAGAACATGAGGTGAATCTTGAATTTGACATTAAAAAAGAACAATTACACTCTACAATAGATTTACCGGATTTTAAAATGGAATTTCAAGATTGTGATGAAGAATTAAATTCAGAGCGGAGCATCAATAGAGATTCCAGAACACAGGAACGAAGTTGTAAAAATATTGGCGATAAACCTTTTAAATGTAAAATTTGTTCGAAATGTTTCACACAGTCCAGTAATTTACAAAAACATATTAGAATTCACAATGACGAAAAACCTTTTAAATGTGAAATTTGTTCGAAATGTTTCACACAATCCTGTAATTTAAAAAAACATATTAGAATTCACAGTGACGAGAAACCTTTTAAATGTACAATTTGTTCGAAATGTTTCAGACAATCCAGTCATTTAAAATCGCATATTATAACTCACACTAACGAAAAACCTTTTAAATGTAAAATATGTTCGAAATGTTTCACACAATTGTCTCATTTAAAAAGTCATATTAGAACTCACACTAACGAAAAACCTTTTAAATGTAAAATTTGTTCGAAATGTTTTACACGATTTGATATTTTAAAAACGCATATTAGAACTCACATTAACGAGAAACCTTTTAAATGTGAAATATGTTCAAAATATTTCAAAAAATCTATTAGTTTAAAAAAACATATTAGCACTCACATTGACAAAAACGTAACGTAA
Protein Sequence: MDISVIKQEEIEIESKSACFDQREIIEEHEVNLEFDIKKEQLHSTIDLPDFKMEFQDCDEELNSERSINRDSRTQERSCKNIGDKPFKCKICSKCFTQSSNLQKHIRIHNDEKPFKCEICSKCFTQSCNLKKHIRIHSDEKPFKCTICSKCFRQSSHLKSHIITHTNEKPFKCKICSKCFTQLSHLKSHIRTHTNEKPFKCKICSKCFTRFDILKTHIRTHINEKPFKCEICSKYFKKSISLKKHISTHIDKNVT

Sequence clustering based on sequence similarity using MMseqs2