Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.054 6.5e+02 1.5 0.1 36 51 2 17 1 20 0.82

2 5 2.4e-05 0.29 12.3 0.3 20 51 30 60 12 63 0.82

3 5 3.3e-05 0.4 11.8 0.1 21 51 74 103 69 106 0.87

4 5 3.3e-05 0.4 11.8 0.1 21 51 117 146 112 149 0.87

5 5 0.00012 1.4 10.1 0.1 21 53 160 191 155 192 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.054	6.5e+02	1.5	0.1	36	51	2	17	1	20	0.82
2	5	2.4e-05	0.29	12.3	0.3	20	51	30	60	12	63	0.82
3	5	3.3e-05	0.4	11.8	0.1	21	51	74	103	69	106	0.87
4	5	3.3e-05	0.4	11.8	0.1	21	51	117	146	112	149	0.87
5	5	0.00012	1.4	10.1	0.1	21	53	160	191	155	192	0.89

Coding Sequence: ATGCAACAGGCGAGTCTGCGGCTGCACCAGGAGATCAAACATGCCGGCAAGGGGCCCGTATGCGAGGTAACACACTTACAATTTCAGAGGAAGGAGCAGAAGGTGGAGTGCGACGTGTGCCACACAACGATGCAACAGGCGAGTCTGCGGCTGCACCAGGAGATCAAACATGCCGGCAAGGGGCCCGTATGCGAGGTAACACACTTACAATTTCAGAGGAAGGAGCAGAAGGTGGAGTGCGACGTGTGCCACACAACGATGCAACAGGCGAGTCTGCGGCTGCACCAGGAGATCAAACATGCCGGCAAGGGGCCCGTATGCGAGGTAACACACTTACAATTTCAGAGGAAGGAGCAGAAGGTGGAGTGCGACGTGTGCCACACAACGATGCAACAGGCGAGTCTGCGGCTGCACCAGGAGATCAAACATGCCGGCAAGGGGCCCGTATGCGAGGTAACACACTTACAATTTCAGAGGAAGGAGCAGAAGGTGGAGTGCGACGTGTGCCACACAACTATGCAACAGGCGAGTCTGCGGCTGCACCAGAAGATCAAACATGCCGGCAAGGGGGGCCCGTATGCGAGGTAA
Protein Sequence: MQQASLRLHQEIKHAGKGPVCEVTHLQFQRKEQKVECDVCHTTMQQASLRLHQEIKHAGKGPVCEVTHLQFQRKEQKVECDVCHTTMQQASLRLHQEIKHAGKGPVCEVTHLQFQRKEQKVECDVCHTTMQQASLRLHQEIKHAGKGPVCEVTHLQFQRKEQKVECDVCHTTMQQASLRLHQKIKHAGKGGPYAR

Sequence clustering based on sequence similarity using MMseqs2