Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.13 1.9e+03 1.7 0.1 24 44 2 22 1 31 0.86

2 10 0.95 1.4e+04 -1.1 0.0 23 46 29 52 26 60 0.81

3 10 0.0003 4.4 10.1 0.4 22 44 56 78 52 86 0.86

4 10 0.92 1.4e+04 -1.0 0.0 21 44 83 106 80 114 0.84

5 10 0.011 1.7e+02 5.1 0.1 21 45 111 135 100 142 0.85

6 10 0.001 15 8.4 0.1 21 48 139 166 124 171 0.76

7 10 0.022 3.3e+02 4.2 0.4 23 44 169 190 164 195 0.91

8 10 0.0092 1.4e+02 5.4 0.0 18 43 220 245 217 250 0.90

9 10 0.00021 3.1 10.6 0.0 21 44 251 274 246 279 0.87

10 10 2.1 3.1e+04 -2.2 0.0 27 48 290 311 282 313 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.13	1.9e+03	1.7	0.1	24	44	2	22	1	31	0.86
2	10	0.95	1.4e+04	-1.1	0.0	23	46	29	52	26	60	0.81
3	10	0.0003	4.4	10.1	0.4	22	44	56	78	52	86	0.86
4	10	0.92	1.4e+04	-1.0	0.0	21	44	83	106	80	114	0.84
5	10	0.011	1.7e+02	5.1	0.1	21	45	111	135	100	142	0.85
6	10	0.001	15	8.4	0.1	21	48	139	166	124	171	0.76
7	10	0.022	3.3e+02	4.2	0.4	23	44	169	190	164	195	0.91
8	10	0.0092	1.4e+02	5.4	0.0	18	43	220	245	217	250	0.90
9	10	0.00021	3.1	10.6	0.0	21	44	251	274	246	279	0.87
10	10	2.1	3.1e+04	-2.2	0.0	27	48	290	311	282	313	0.75

Coding Sequence: atgccaTTCAAGTGTAAAATCTGTCCGGCGAAATTTGGAAAGAAATCCCATCTGAACAGACACGTGTTTATCCACACCGGCCAACGACCTTTCAAATGCCTCTTGTGCGCGGCGACCTTTCCGTACCAAGAGTCGCTGAAGGGACATATCAAGATCCACACGGAGGAGAAGTCTTGCGTGTGTCCAATTTGCGGAGCCGCTTTCATCTCCACGAGCGTTTTGAGACGTCATGTCCTCACGCACACGAAAGAGAGGCCTTACAAGTGCCTTGAGTGCGGCGCGACGTACCGCGACCAAGGGATGATGAAGACGCATATGTTGACCCATTCTGGTGAACGACCGTACCCGTGTACCATATGCGATATGACCTTCACCTCCAAACCGCATTTACGACGGCATTCGATGATCCACACGGGCGAAAAGCCTTACGAGTGTTTACTGTGCGGGGCGAAGTTCTCGCAAAACTACAATCTCAAGATGCACATCAATTCGCACACCGGGGTTAAACCGTACGCCTGCCATGTTTGCGACGCGACCTTCGCTTGTCACCGGTCACTGAAGGAACACCTCTGCACACACTCGGGGGAACGGATGTTCAAGTGCGACATTTGCGGGGAGGAATTCATCTACCGCAATCGATTGAAGACGCACATCCTACGACACAACGGGGAGAAACCGCACGAATGTGAGGTTTGTGGGGCAAAATTCACTGACCATACTCATCTGAAGAGACATTCGTACGTGCACCGGCAGGAAAAGCCGCATACGTGTCCATTATGCAAGGCCGGGTTCGTGGAAAACTCCGCTCTTCAGAAACATATGGTGATACACACAAACGACGGGACGGAAGAAAAGCCTCTGTACCGGTGTATCTTCTGCAACGCGGGGTATCCTAGTCACAAAGGACTCAAGTTGCATTTCACTAAGAGGCACAGTGTGGACGAGCTCTGTTCGGTGATCTCGTAA
Protein Sequence: MPFKCKICPAKFGKKSHLNRHVFIHTGQRPFKCLLCAATFPYQESLKGHIKIHTEEKSCVCPICGAAFISTSVLRRHVLTHTKERPYKCLECGATYRDQGMMKTHMLTHSGERPYPCTICDMTFTSKPHLRRHSMIHTGEKPYECLLCGAKFSQNYNLKMHINSHTGVKPYACHVCDATFACHRSLKEHLCTHSGERMFKCDICGEEFIYRNRLKTHILRHNGEKPHECEVCGAKFTDHTHLKRHSYVHRQEKPHTCPLCKAGFVENSALQKHMVIHTNDGTEEKPLYRCIFCNAGYPSHKGLKLHFTKRHSVDELCSVIS

Sequence clustering based on sequence similarity using MMseqs2