Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.042 45 6.9 0.2 83 109 48 74 43 75 0.92

2 4 3 3.3e+03 0.9 0.0 76 108 73 105 72 107 0.89

3 4 2.3e-19 2.5e-16 62.4 0.1 8 97 166 255 160 269 0.87

4 4 0.66 7.2e+02 3.0 0.1 76 100 268 292 258 301 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.042	45	6.9	0.2	83	109	48	74	43	75	0.92
2	4	3	3.3e+03	0.9	0.0	76	108	73	105	72	107	0.89
3	4	2.3e-19	2.5e-16	62.4	0.1	8	97	166	255	160	269	0.87
4	4	0.66	7.2e+02	3.0	0.1	76	100	268	292	258	301	0.81

Coding Sequence: ATGCCGCCTACCTCGGACTGGGGCAAGGCCTCCGTCTTCCCTTCCGATGCTGAACCCAGCCGACCAATCAGACGCAGTTTAGCGTGTAACGTCACGGAATTCTTCATTGAAGACCCGAATTCCCACAAGATTGTACTTCTCATGATGGATGTCTATAGGCTAGCAGTTCAGTTTCATATGAAGAGATTGGAACAACTGTGTGTTCAGTATCTTGAAACATCGATCACCCATCGCAATGTGTTGGATGCCCTCCATAACGCAACCACTCTCAAGCTCTTCTACATCAAGGAGTTCTGTCTCAAGTTCATTGTCAGAGAGTCCAACTACAACCACATCATAATGAGCAAAGATTTCGAGACCTTGGAGAAGTCGCTGATGGTAGAAGTGATAAGGAGGCAGAGGATGCCCCATATAAGAAATTTGCTGGAGCCTCAGTTCGACAATACagGCACCACACTAGAGCAAGATATGGAGTGCTTCCTCAAGTATTCCGGGAAGGAGTTTTGTGACATCACACTTATGTTGGATGGAGAGGCCATCCCTTCCCACAAGTCCATACTGGCTGCGCGGTGCAGCTACTTCGAAGCCATGTTCCGATCTTTCATGCCGGTAGACAATGTTGTTCATATACAAATTGGCGAGATGGTGCCTTCTCGTCAATCATTTGACTCTCTCCTTCGGTACATTTACTATGCtgacgtcaacatgcccccagaAGACTCTCTGTACCTCTTCAGTGCTCCTTACTTCTACGGATTCACCAACAATAGACTGCAGGCATTCTGCAAGCAAAATCTTGAGATGAATGTAACTTTTGAAAATGTCATCCAAATTCTGGAAGCAGCCGATAGAATGCAAGCAGCAGATATGAAGAAGTATTCATTGAACTTGATTGTTCATCACTTTCCTAAGGTCGCACGGCTGCCGAAGATCCGGTTGCTGAGTCAAGAGCTGCTGCTGGATATCTTGACTGCGTTGGCCGATGACATGAGCGACAGCAAGATGTGTCAGGACATGTCCAGCATCAGTCTCAGCAGCGAGACCTACTGA
Protein Sequence: MPPTSDWGKASVFPSDAEPSRPIRRSLACNVTEFFIEDPNSHKIVLLMMDVYRLAVQFHMKRLEQLCVQYLETSITHRNVLDALHNATTLKLFYIKEFCLKFIVRESNYNHIIMSKDFETLEKSLMVEVIRRQRMPHIRNLLEPQFDNTGTTLEQDMECFLKYSGKEFCDITLMLDGEAIPSHKSILAARCSYFEAMFRSFMPVDNVVHIQIGEMVPSRQSFDSLLRYIYYADVNMPPEDSLYLFSAPYFYGFTNNRLQAFCKQNLEMNVTFENVIQILEAADRMQAADMKKYSLNLIVHHFPKVARLPKIRLLSQELLLDILTALADDMSDSKMCQDMSSISLSSETY

Sequence clustering based on sequence similarity using MMseqs2