Basic Information

Gene Symbol
foxn3
Assembly
GCA_963675035.1
Location
OY776117.1:140211011-140241190[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 4.2 2e+04 -1.6 0.0 1 10 226 235 226 238 0.89
2 8 7.3 3.3e+04 -2.3 0.0 2 10 248 256 247 259 0.90
3 8 0.14 6.3e+02 3.2 0.0 1 13 268 280 268 288 0.87
4 8 3.9 1.8e+04 -1.5 0.0 1 10 289 298 289 302 0.88
5 8 3.9 1.8e+04 -1.5 0.0 1 10 310 319 310 323 0.88
6 8 0.14 6.5e+02 3.2 0.0 1 13 331 343 331 350 0.88
7 8 3.9 1.8e+04 -1.5 0.0 1 10 352 361 352 365 0.88
8 8 4e-36 1.8e-32 113.9 0.0 1 85 373 455 373 458 0.95

Sequence Information

Coding Sequence
ATGCCTGGTTCTGTTCGCATTCCACCAGATCTTATCAAACCTAACGCTGAAAACATAACACAGACGTTTGATTTTCAAGAGATGCCTGGTTCTGTTTGCATTCCACCAGATCTTATCAAACCTAACGCTGAAAACATAACACAGGCGTTTGATTTTCAAGAGATGCCGGGTTCTGTTCGCATTCCACCAGATCTTATCAAACCTAACGCTGAAAACATAACACAGGCGTTTGATTTTCAAGAGATGCCTGGTTCTGTTCGCATTCCACCAGATCTTATCAAACCTAATGCTGAAAACATAACACAGGCGTTTGATTTTCAAGAGATGCCTGGTTCTGTTCGCATTCCACCTGATCTTATCAAACCTATAGACTTTTTTCAAGAGGGAGATGGAGCGTCTGAGATGCGTTCTGAGGATGATGATCTCACCTCCTTGACCTGGCTTCAAGACAAAAATCTGCTGAAAGGTATAAATCTGCGCACTGCCGGAGCAGGGGTTCAGGAGTCGCCGACGAGTGACTACGTAGACGACAGCACCAGCGAGCGAGACTCTTCCTGTTCTAGTGTCAACAGCAGCAGCCCCACCCCACCCCCCACCAGTGCTGCCACCCCCGCGCCAGCTGTCAAAAATAAGCACCCCCACCACATACCATACGACCCCCAGATTCACACGACATCGAAGCCTCCCTACTCCTTCTCTTGCCTGAACTTCGCTCGTTGTTTCCAGATTCACACGACATTGAAGCCTCCCTACTCCTTCTCTTGCCTGAACTTCGCTTGTTGTTTCCAGATTCACACGACATCGAAGCCTCCCTACTCCTTCTCTTGCCTGATCTTCGCTTGTTGTTTCCAGATTCACACAACATCGAAGCCTCCCTACTCCTTCTCTTGCCTGAACTTCGCTTGTTGTTTCCAGATTCACATGACATCGAAGCCTCCCTACTCCTTCTCTTGCCTGAACTTCGCTTGTTGTTTCCAGATTCACACGACATCGAAGCCTCCCTACTCCTTCTCTTGCCTGATCTTCGCTTGTTGTTTCCAGATTCACACGCCATCGAAGCCTCCCTACTCCTTCTCTTGCCTGAACTTCGCTTGTTGTTTCCAGATTCACACGACATCGAAGCCTCCCTACTCCTTCTCTTGCCTGATCTTCATGGCTATAGAGGAGTCTCCTGTTAAGGCTCTGCCTGTTAAGGAGATCTACAACTGGATTCTGGACCACTTTCCTTTCTACAAGAATGCCCCGACCGGCTGGAAGAACAGCGTCAGACATAACCTCTCCCTCAACAAGTGCTTCCGCAAAGTCGACAAAGCGCCGAACCTGGGTAAGGGCTCGCTGTGGATGGTAGACCCGTTGTACCGCTCCAATCTACTGACGGCCCTGCAGAAGGCTCCATACCACCCATGCAGCTCCCTGGATACCAGCAGTGCGCCCTCCTCCGCAACCACCAGTGATGAAGAAAGTGATGTGAATATTGATTTAACATCTGAAGAATATCAGGACTATAGTTTTAGTGGTCTTGTTCGTGAGTCCGACTACATCTACGAACTTGGTTATAGCGACGAGCCCATTGCAGGGCTTTCAGAGCTAAATTCAAAAGTGGGTATGCCAGGGCAGGTTGTACTGACACTTACAGAGCCTTTTTTCAACCTAGGCCACAAACTGTACATTGATAACTGTCCCAAGAGCCCGTCAGGAAAGGCTGGAGGCGGGGGTGGTGGAGGCAGGTTGCCAGACCCGTCCCTGTTCCCGTACCTGGCCCGGCGGTTGGCAGCCGTGGAGGGCTCGGGGCCGCTAGATGACGTGGACGCAGCCGCAGCCATGCTGGAGCTCAAGCACGGACCACTGCGACGGGGTGAGTAA
Protein Sequence
MPGSVRIPPDLIKPNAENITQTFDFQEMPGSVCIPPDLIKPNAENITQAFDFQEMPGSVRIPPDLIKPNAENITQAFDFQEMPGSVRIPPDLIKPNAENITQAFDFQEMPGSVRIPPDLIKPIDFFQEGDGASEMRSEDDDLTSLTWLQDKNLLKGINLRTAGAGVQESPTSDYVDDSTSERDSSCSSVNSSSPTPPPTSAATPAPAVKNKHPHHIPYDPQIHTTSKPPYSFSCLNFARCFQIHTTLKPPYSFSCLNFACCFQIHTTSKPPYSFSCLIFACCFQIHTTSKPPYSFSCLNFACCFQIHMTSKPPYSFSCLNFACCFQIHTTSKPPYSFSCLIFACCFQIHTPSKPPYSFSCLNFACCFQIHTTSKPPYSFSCLIFMAIEESPVKALPVKEIYNWILDHFPFYKNAPTGWKNSVRHNLSLNKCFRKVDKAPNLGKGSLWMVDPLYRSNLLTALQKAPYHPCSSLDTSSAPSSATTSDEESDVNIDLTSEEYQDYSFSGLVRESDYIYELGYSDEPIAGLSELNSKVGMPGQVVLTLTEPFFNLGHKLYIDNCPKSPSGKAGGGGGGGRLPDPSLFPYLARRLAAVEGSGPLDDVDAAAAMLELKHGPLRRGE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-