Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_932294395.1
Location
CAKOAO010000081.1:790450-809828[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.1 5.6e+03 -2.5 0.0 49 72 117 141 113 143 0.81
2 2 4.5e-17 1.2e-13 50.9 0.0 5 58 736 789 732 816 0.88

Sequence Information

Coding Sequence
ATGGCcgtaaaaaaatgttgtattgaCTACTGTAAATCATGTTCTACGAGAAAGGAAGACAAAGGTGTAACATACCACAAGTTTCCCAAAAACACTTTATTACGTCACCGTTGGATATTCGTAACACATAATGAACACATAGACACCGATTTGCCCAAGTACGTGTGCTCAcggcatttctgtaaaaacGATTTTCAAATGTACAAGGACTCTAAATACATATTGAAATCAGATGCGGTACCTTCAATATTTCCGTGGGACTCTGACACTGAAGAAGAATTAGAAGCTTTAAATATGCCAGGAGAAGGTAGTAGTACCAAAGAGTGTGAAGTTGAGAATGTGGATGCTATCAAGAAGTATATTGAAGCACAAGAGAAAGAGATTCAGGACCAGAAGTTAGCTGATTTTCAGCTTAGTGAGAAGAGTAATGATGTCACAGATAATAAGCCAAGTCGAGAAGAAACAATGTCTGTGGCCAGTAGTGTGATTGATATGATAATCAGTGAGTCTGAATTAGAGATTGCCAGGAAGCAAGATGTGAAAAGCAAGCAGATTTTCAGTCCAGGGGACAGAGGTAACGGCAGTATGGCGCTTTCCGTCGGGTCTAAGGTGGAAGCGAAGGACTTCGGTGAAGAATGGTATCCAGCAGTCATTATAGAGGTCGACTATGACGATATGGAGGTGCTTGTACATTATGAAATTGATTCCAAAAAACATGACGAATGGATAAGCGTGAGTAGTCCACGTCTGCGACCCGTCAGTACGTCCACTCCTAGCAGTAGTACTACAACTACGACTACGGTCAAACCAGGCCCCAGTTCTGAAGAGAGCCTCACCGATACCATACCGATAGCCAATTTGAAGGAGGAACCTAAAGATGTGAAGGCAGAAGACAAGATTAAGCTAAGCTATGCAGTGGGCGAGCGATGCCTCGCAAGGTGGCGCGATAATAGGCGATTTATAGCTACCATACTTAATGATTTGGGAAATGGCAATTACGAGATTATTTTCGATGACGGTTGTCATTGGACGTGTAACACGTCGCGGCTTCACAAACAGCGCTCGAAAAAGGGCGATGTTACTGACGTGACGTCTGCTCCCGGTCCGTACGGGGCCGGACCTAGCAATGCGACCCCGCAACCCACCACCCTGTACCCTGCCTACCACACCCACCTGTTTGACCCCACTCGCGATTACCTAGGCTCCAAAAGCGAACGACGCGAAATGAAAcgtaaattaaacataaaagaaatattcaatataggacagaaaaaatataagaagCAGAGGGTTCAGAaggaaaagacacagaaaatgGTGGAAAGGAAACCGAGGGTTATGAAGAAGAGGCGGGAGAAAGTTGTGAAGCTGAAGCTCGAGAGTGAAGTCAAGATTGAGGTGAAGACTGAACTGCCTGCCGTAGATGCCGTAGCTTCAATAATTGGCACGGTAAGCCAAGACGAAACACTTGCTCAGGAAGATACAGAAGACGAGAACCCGGAACAAGTCCAAGACGATATGGAACAAGACATGAAACTAGAAACTAATGATAACGATGATGAAGTGGCCGCAAGTAATGGTATCAGAAATGAAGATCTAATTCAGTTGGAAGATCTTAAATGTGAATCAGACCCGGTTCTAGAAGAGGAGGTGAAACTAGAACAGTTCGATAAACCTGACGATGTCCGACACGAGGAAGTGATTGACAGAATAAAAGAAGTCATTAACAAACTGGAGGATGGCTTGAACCAAGTCGAAAAGATCAGCTCGCCCAAACCGGAACCGAAAGAAGAAGTTGTTACTGTTGGAACTCCAGATGAAAAGTCTCCAAAATTAGAAAGCATACCAGTAAAAGTGGAAAATTCAAAAgtgaaaatagaaaaagaaattgaaaaaccgAAAAAGCTGAAGAAGGGTAAAAAGCTAAGATTGTTACGGGAAGAAAATGTGAATAAACAAGTGGAAAAAGTGAAAAATGAGTTAGAACAGGTTCGGAAGCAAGTGGACGAGATGCGGAAACAGATGTTGAAGCGGTCGGAGTGCATGAAGACAGAGCCGGGGGTCGAGATGAGCGAGAGCTTCCTGCTGCCGGGCGAGTGGTGCTGTCACTGGGTTAATGGACAGCCCGTCGGCACCGTGAGCGAGATCGAGAGCGAACACAAGCAGGACGCCAGCGGGAAGGCGCCCCTACCCAGGAGAAGTGTGCAGGTTGAAGACAAGAGACTACCGCCGGGCTGGACCAAACACATGGTTCGCAGGAGCTTCGGGAATTCTGCCGGCAAGTGGGATGTTGTGCTCATCAGCCCCGACAACCGAAGATTTCACACCAGGAACGAAATACGCACGTACCTCGAGAACAACGCGAACTTGGGTCTGTCGGCATACTCGCACGCGCTGACGGACTTCGGCGTGCACCTGAAGCTGGCGCGGCGCATGGGCTGGCTGGCGCGCACGCCCGGCggcgcgccccccgcgccccccgcgccctccGCGCCGCGCGCGCTGCCCGACACCTCGCCGCTCGTCAAGCGCCGGCGCCGCGGCCTCAAGAGGGACGCCGAGCTCAAGAGGAAGCCTAGGATTACTATTAAGATGAAGATCCCACGGGCGGAGGCCGATCTGTCAGGGGAAGCCGCAGCTGCGTCTCCAGGTGTGGATGGCAGTATTCCTGATGACGCGAACATTGAAACACCCACGTTAGAAGATGGATATGTATACGTAGGGTCGCTAAAAGTGCAAATAATCGAGAACCTACTTCGTTGCCCGGCCGAAGGATGTTTCAAGAACTTCCGAAACAATACTCTACTGAAAATGCACATAAAACACTACCACAGAGAACTGAGAAAGATGATGGGAGCAACTCCCAAAGTCCTAGATCTAGCGTACGCCAGGACCATGCCAGTGGCGGCCGAGACTCCTCGCTCGAAAGACGAACAGAAGATCATTAAGGTCAAGATACCAAGGCCACCGAAACGTGAGGAGCCCAAACAAGAAATTAAGGACGTTCATGTCGAACTACAAGTTGACACCGGACGTCTAACACCCGTCAATGACCCCGATATTCCCATACCGAGGAGCCAGGATTCACCCAAACTGCGCCAAGCGTTGATCAACAAGCCTGTCAAACGACCCCGAGTGCTGCTTCCAGTCCGAAGAGTTGAGCCCGAACAGGCGATACCAGACTCCATGAACGAGGATATAGACATTGAGGACACGCTGCAAATTGAACCGATCATAGAAATCCCGACTTTAGATGTGCCTTTGGACTTCGAGAGTGCCATTTCCACCCACACCGTGACTAAGCCTGTGCTAGAGAAGAGAATGAGGAGTGAGAAGAGGCGGAAGACTTTCGCTGTGGCCGCAAAGAGGCCTATCAGTGACGACGAGGACTGGTTCGCTATGAACTCTGACGTTGAGACCCGCTCCAGTTTCCCGCGGTCTGGAACGCCTGATTCTAAGATTGAATGCAAAGCTGTGCCGATTTCGTCAGAGTTTAGTGAAGAGAATAAGGAACCCAATCTATATATGACGACTGAGAACGGCGAGCGCATAAAGATAGTGCACATGAAACGCGAGGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAAGACGGCTTGATGGTGCAGTGCGAACTGTGCTTGTGTTGGCAACACGCGCTCTGTCACAACATACAGCGCGAGTGTGACGTGCCAGAAAAATACACATGCAGCATTTGCCTGAACCCTCGTCGCGGTCGTCGCTCGCAGCGGTTCGTGCATGACCAGGACCGCATGTACGAGGGGCTGCTGCCGGGGGCGCGGCCCTGCGAGGCGCTGCGGCGCAGCCACGAGCTGGCCGGGAACCTGCTGCGGATAGATGACGCGCTCAACGCGTTGAGGATCAAGTACTATGTGGCCACCAAAAAAGACCATCCAAAGCTGTACCTATGGGCCCAAGACTGGGAGCAGGCAGAGATTCAGTACACGCAAGAGAAGCTTAACTCTGACTATTCGGacttgaacatcatgatcagtTCCATCGGCAAGGAGAACCTGCCCGTCAAGCCGGAAGACGTCAAAGACATGCCCATGGATATACGCACCCCGCCCTCGGAGGAACATGAGACTGACAGGTACATACAAAGGGAAGGCCCTCTCGGAAATCAGAGTTTGCTCAGTGGGCTGCTGTCGAGTCCCGGCGGAGCGTCACTTGAGCTACCGATCAGCTCGTCCGAGTTGGAACGACTGGCCAAGTCTGTTGAAGAGCAAGAGGCCCAACGTCCAGTAATAATGGCCCCGCAGCCCGAGGCGGCGATAGAGAACAGTGTGTGTCGCGAACGTTTGTTGAAGCACCTGCAGCGATGCCAGGCGCTCATCGACGCTCGACTGGATTCTATCGAGGCGCAGGTGGCAGAACTGGAGTCTCAAGACCCATCGTTGGAGGACGACGAGACAGCGGATTACTTCCCGCGCACCAAACAGACCATACAGATGATGATGCGCGACCTTGATAACATGGAGGAGCTCGCAGTCATCACCTAA
Protein Sequence
MAVKKCCIDYCKSCSTRKEDKGVTYHKFPKNTLLRHRWIFVTHNEHIDTDLPKYVCSRHFCKNDFQMYKDSKYILKSDAVPSIFPWDSDTEEELEALNMPGEGSSTKECEVENVDAIKKYIEAQEKEIQDQKLADFQLSEKSNDVTDNKPSREETMSVASSVIDMIISESELEIARKQDVKSKQIFSPGDRGNGSMALSVGSKVEAKDFGEEWYPAVIIEVDYDDMEVLVHYEIDSKKHDEWISVSSPRLRPVSTSTPSSSTTTTTTVKPGPSSEESLTDTIPIANLKEEPKDVKAEDKIKLSYAVGERCLARWRDNRRFIATILNDLGNGNYEIIFDDGCHWTCNTSRLHKQRSKKGDVTDVTSAPGPYGAGPSNATPQPTTLYPAYHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKYKKQRVQKEKTQKMVERKPRVMKKRREKVVKLKLESEVKIEVKTELPAVDAVASIIGTVSQDETLAQEDTEDENPEQVQDDMEQDMKLETNDNDDEVAASNGIRNEDLIQLEDLKCESDPVLEEEVKLEQFDKPDDVRHEEVIDRIKEVINKLEDGLNQVEKISSPKPEPKEEVVTVGTPDEKSPKLESIPVKVENSKVKIEKEIEKPKKLKKGKKLRLLREENVNKQVEKVKNELEQVRKQVDEMRKQMLKRSECMKTEPGVEMSESFLLPGEWCCHWVNGQPVGTVSEIESEHKQDASGKAPLPRRSVQVEDKRLPPGWTKHMVRRSFGNSAGKWDVVLISPDNRRFHTRNEIRTYLENNANLGLSAYSHALTDFGVHLKLARRMGWLARTPGGAPPAPPAPSAPRALPDTSPLVKRRRRGLKRDAELKRKPRITIKMKIPRAEADLSGEAAAASPGVDGSIPDDANIETPTLEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLKMHIKHYHRELRKMMGATPKVLDLAYARTMPVAAETPRSKDEQKIIKVKIPRPPKREEPKQEIKDVHVELQVDTGRLTPVNDPDIPIPRSQDSPKLRQALINKPVKRPRVLLPVRRVEPEQAIPDSMNEDIDIEDTLQIEPIIEIPTLDVPLDFESAISTHTVTKPVLEKRMRSEKRRKTFAVAAKRPISDDEDWFAMNSDVETRSSFPRSGTPDSKIECKAVPISSEFSEENKEPNLYMTTENGERIKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQRECDVPEKYTCSICLNPRRGRRSQRFVHDQDRMYEGLLPGARPCEALRRSHELAGNLLRIDDALNALRIKYYVATKKDHPKLYLWAQDWEQAEIQYTQEKLNSDYSDLNIMISSIGKENLPVKPEDVKDMPMDIRTPPSEEHETDRYIQREGPLGNQSLLSGLLSSPGGASLELPISSSELERLAKSVEEQEAQRPVIMAPQPEAAIENSVCRERLLKHLQRCQALIDARLDSIEAQVAELESQDPSLEDDETADYFPRTKQTIQMMMRDLDNMEELAVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00049991;
80% Identity
iTF_00049991;