Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.2e-43 2.9e-40 136.2 0.1 2 87 60 144 59 145 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.2e-43	2.9e-40	136.2	0.1	2	87	60	144	59	145	0.97

Coding Sequence: ATGCACACCATCTTCGGGGAACACCAGAATGCCTATTACAGGCATGCAGCTTCCGGAGGATACACCGCTGCAGTGTCGGCCACTGCAAACCCCTATAGTTACGAGCAATACTCCAGGTATGGGTACGCTGCTTGGCCACACCAACAGCACCAGCTCTCGGCCGCCAAGGATATGGTGAAACCGCCGTACAGTTACATTGCCCTCATTGCCATGGCGATACAGAACGCTGCTGATAAGAAGATCACTCTGAACGGCATTTACCAGTTCATTATGGACCGCTTTCCATACTACAGGGAGAACAAGCAGGGATGGCAGAACTCCATCCGGCATAACCTCAGTCTCAACGAGTGTTTCGTCAAGGTGCCACGTGACGACAAGAAACCAGGCAAGGGCAGCTACTGGACGCTGGACCCTGATAGCTACAACATGTTCGACAACGGGTCGTAtctccggcggcggcggcgttttAAGAAGAAGGACGCCATCAGGGAGAAGGAGGAGGCCATGAAGCGACAAGTGGAGTCCTTGGTGAAGCGCGATGATAAGCTGCATGAGGACAAGGGCAAGATTGATCTGAAGCTGAAACGCGAACCGGCCGACTTGAACCAGTGCATGAACAAGTATCACGATAGCAAGTCGGTGATTGTGCATCACCAGGAGCATGTCATCAGCGATGTCACCGCCTCGCTGCAGGCCATGGACTCTGCAGCCGCCTTCAGCGTTGACAGTCTGATGACCTCAAGGGAGCAATCGCACCACGGCAACTACCCTTCGCCACGTTTGCATTCCTCCGGCGGCATGTACTCGTACTGCCCCAGTGCCGCTTCCCAGCAGTACGTCACCGACGAGAATACCCCGAGGTACAGTCCCTGGTACAGCCCGGAAACGTCGCCCGAGTCGGCGACGAATGCGTCCGGATACAGAGATATCATCTTCGACTCCACGGCCCCGGCCAGCTGCCAGCTATCCAGCTTCAGACACAGCGGGGTACCACCCAGTCCCCCGAACTACAGACCTCCGGCTTCCAGCTACTATCAGCAGGACTGTGTCGGGCAGAAGTACTGA
Protein Sequence: MHTIFGEHQNAYYRHAASGGYTAAVSATANPYSYEQYSRYGYAAWPHQQHQLSAAKDMVKPPYSYIALIAMAIQNAADKKITLNGIYQFIMDRFPYYRENKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFDNGSYLRRRRRFKKKDAIREKEEAMKRQVESLVKRDDKLHEDKGKIDLKLKREPADLNQCMNKYHDSKSVIVHHQEHVISDVTASLQAMDSAAAFSVDSLMTSREQSHHGNYPSPRLHSSGGMYSYCPSAASQQYVTDENTPRYSPWYSPETSPESATNASGYRDIIFDSTAPASCQLSSFRHSGVPPSPPNYRPPASSYYQQDCVGQKY

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00429688; iTF_00083706; iTF_00049061; iTF_00902039; iTF_01196511; iTF_00369378; iTF_01400164; iTF_00920463; iTF_01126159; iTF_01184305; iTF_01096416; iTF_01185984;
90% Identity: iTF_00083706;
80% Identity: -