Acla025644.1
Basic Information
- Insect
- Agrotis clavis
- Gene Symbol
- STAG1
- Assembly
- GCA_954870645.1
- Location
- OX940931.1:24924452-24954422[-]
Transcription Factor Domain
- TF Family
- DACH
- Domain
- DACH domain
- PFAM
- AnimalTFDB
- TF Group
- Unclassified Structure
- Description
- This family of proteins includes transcription factors involved in the regulation of organogenesis. Members of this family appear to regulate the SIX1, SIX6, and possibly SIX5 genes, influencing myogenesis and the proliferation of precursor cells in myoblasts. They are known to act as corepressors or coactivators in these processes, depending on their interaction with other proteins such as EYA3, CREBBP, NCOR1, TBL1, HDAC1, and HDAC3. These proteins are also implicated in the repression of cyclin-dependent kinase inhibitors, including the p27Kip1 promoter, which is key in cell cycle regulation. Some family members inhibit TGF-beta signaling through interactions with SMAD4. They are characterized by a conserved DNA-binding domain known as the DACHbox-N or DD1 domain, which is structurally similar to the forkhead/winged helix domain and is responsible for their DNA-binding activity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 13 0.00033 5.5 8.0 0.0 78 141 596 658 589 677 0.82 2 13 0.075 1.3e+03 0.3 0.0 97 144 656 703 651 731 0.74 3 13 0.045 7.6e+02 1.0 0.0 93 144 694 745 680 772 0.78 4 13 0.058 9.7e+02 0.6 0.0 95 144 738 787 727 814 0.75 5 13 0.029 4.8e+02 1.6 0.0 92 144 777 829 766 858 0.76 6 13 0.055 9.2e+02 0.7 0.0 94 142 821 869 808 888 0.78 7 13 0.038 6.4e+02 1.2 0.0 94 144 863 913 843 944 0.74 8 13 0.039 6.5e+02 1.2 0.0 93 144 904 955 878 983 0.76 9 13 0.036 6.1e+02 1.3 0.0 95 145 948 998 934 1032 0.67 10 13 0.05 8.3e+02 0.9 0.0 93 144 988 1039 974 1058 0.78 11 13 0.045 7.6e+02 1.0 0.0 95 145 1032 1082 1021 1111 0.73 12 13 0.039 6.5e+02 1.2 0.0 94 144 1073 1123 1054 1154 0.74 13 13 0.049 8.2e+02 0.9 0.0 93 144 1114 1165 1100 1185 0.78
Sequence Information
- Coding Sequence
- ATGGCGGAAATAGGAATCTGGATGGAGAAATTCCCGGCACACTTTTTGGATGACCTCTACCTCAAATACATTGGTTGGACATTGCATGACAAGGTCGGCGAGGTGCGGCTCCGCTGCCTGCAGGCGCTGCAGCCGCTGTACGAGTGCGAGGAGCTGAAGGGCAAGCTGGAGCTGTTCACGTCCAAGTTCAAGGACCGCATCGTGTCCATGACGCTCGATAAGGAGACTGAAGTCGCTGTGCACGCTGTCAAACTTGTCATCGCCATTTTGAAATGTCGCATGCACCCGGACGTGCTGACGGACAAGGATTGCGAGAACGTGTACGAGCTGGTGTACTCGTCGCAGCGAGCCGTGGCCGCCGCGGCCGGCGAGTTCCTGAACGTGCGTCTGTTCAGGAACGAGgagccgccgccgcccgcgaGGTCGCGCCGCGGGAAGACGCGCCTGCCCAACACGCCGCTCATCAGGGACCTCGTGCAGTTCTTTATAGAGTCCGAGTTGCACGAGCACGGCGCGTACCTGGTGGACTCGCTGATCGAGTCCAACCCCATGATGAAGGACTGGGAGTGCATGACGGACCTGCTGCTGGAGGAGGCCGGGCCCAATGAGGAGGCGCTCGACAACCGACAGGAGTCGTCTCTGATCGAGCTGATGGTGTGCTGCGTGCGGCAGGCCAGCACCGGGGAGCCCCCCGTGGGGCGCGGCGCCAGTCGCAAGCACCACCACATGCTGTCCAAGGAACAGGCCAAGCTGGTGAGCGACGACCGCACGCGGCTGACGGCCCACTTCATCTCCACGCTGCCCGCGCTGCTGGACAAGTTCGGCGCGGACCCGGAGAAGCTCACCAACCTGGTGTCCATCCCGCAGTACTTCGACCTGGAGCTGTACACCACGCAGCGGCAGGAGGGGAACCTGAACCTGCTGCTGAACAAGATCCGCGACATCGTGAGCGTGCAGACGGAGGCCGAGGTGCTGGAGACGTGCGGGCGCACGCTGGAGTACCTGTGCTCCGAGCAGTGCGGCGTGTACACGCGCTGCAACGTGGCGCGCGCCACCATCACCGACATGTGCGTCAACCGGTACAAGGAGGCCATCGACGAGTACCGCAGCCTCATCGAGGGGGGCGAGACGCCGGATGCGGACGAGGTGTTCAACGTGATCAACTCGCTGCGCAAGGTGTCCATCATGTACATGTGCCACAACCTCAACGACACCAACATCTGGGACTCGCTGTTCGAGGACCTGCCCAAGTGCGTCAAGGAGAACGAGACGCAGATGCCGCCGCAGGCGCTGGTGTACGTGGTGCGCGCGTGCTTCTACTCGGTGCTGTGGTCGCTGCACGGCGTGGAGACTCGCGTCAGTGAGGCCGGCGCCTCCGCACTGCGCGAGAGACTGCACGCCTACGTCGCGCACTGCAAGGACATCGTGGCGCGCGGCATCACGCCCGACCTCAAGGAGGAGGCGTACACGTCGCTGTGCGACCTGCTGATCCTGTTCGCGGAGCAGCTGGTGCTGCACCACCCGGGCTCTCCCGCGGTGCGCCAGCTGGTGCTGGAGCCCGACGCCGCGCTCTGCGACATGCTCAACGCCTTCATCCAGGAGTTCGTGTTCGTGCACCACAACTACGACGGACAAGATGAGAGACGCATCGAGGAGCTGCACAAGAGACGGAACTTCCTGGCGGCCTATTGCAAGCTCATCGTGTACAACGTGGCGCCCAtccgccgcgccgccgacgtCTTCAAGCACTACATCAAGTGCTACAACGACTACGGCGACATCATCAAGGccacgctgagcaaggcgcgcGAGATCAACAAACTGAACTGTGCGCTCACCATGGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGATATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTTAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGTATGAACTGTGAGCTGGCCATGCAGGCGCTGTTCACCGACATGCTGCACAAGCACGGCACGCCGCACAGGCAGCTGCCCGAGATGCTGGAGCTCAAGGAGCTGGCCAAGCGGTTCTCCGTGATGTTCGGTCTGGACGCCGTGAAGAACCGCGAGGCGCTGAccgcgctgcaccgcgcgggcATCAGCTTCGCCGCGCTGGAGCAGTCGCCGCACGCCACGCCGTACGGGAAGTCCGGCGCTCCGCCGCACCTCCTGTTCCTGGAGCCGCTCGCTGAGTTCAGCAACAAGCTGCTGCGACAGGACAAACGACAGGTGCTCAAGTTCCTGGACAGCCGCATCCCGCACGGAGTGCAGTGGGGAGACGACTGGGCCGCGCTGCTGGCCTACCGCGGCTCGCTGCTGACGGACGCGCCCGACGAGCGCCCGCCGCCCGCGCGCAAGCACtacgcgcgcagaccacgtgcgTATGACAGCCACTACATGACATATGACTCATAG
- Protein Sequence
- MAEIGIWMEKFPAHFLDDLYLKYIGWTLHDKVGEVRLRCLQALQPLYECEELKGKLELFTSKFKDRIVSMTLDKETEVAVHAVKLVIAILKCRMHPDVLTDKDCENVYELVYSSQRAVAAAAGEFLNVRLFRNEEPPPPARSRRGKTRLPNTPLIRDLVQFFIESELHEHGAYLVDSLIESNPMMKDWECMTDLLLEEAGPNEEALDNRQESSLIELMVCCVRQASTGEPPVGRGASRKHHHMLSKEQAKLVSDDRTRLTAHFISTLPALLDKFGADPEKLTNLVSIPQYFDLELYTTQRQEGNLNLLLNKIRDIVSVQTEAEVLETCGRTLEYLCSEQCGVYTRCNVARATITDMCVNRYKEAIDEYRSLIEGGETPDADEVFNVINSLRKVSIMYMCHNLNDTNIWDSLFEDLPKCVKENETQMPPQALVYVVRACFYSVLWSLHGVETRVSEAGASALRERLHAYVAHCKDIVARGITPDLKEEAYTSLCDLLILFAEQLVLHHPGSPAVRQLVLEPDAALCDMLNAFIQEFVFVHHNYDGQDERRIEELHKRRNFLAAYCKLIVYNVAPIRRAADVFKHYIKCYNDYGDIIKATLSKAREINKLNCALTMELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQDMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKAAARDAGAQGMNCELAMQALFTDMLHKHGTPHRQLPEMLELKELAKRFSVMFGLDAVKNREALTALHRAGISFAALEQSPHATPYGKSGAPPHLLFLEPLAEFSNKLLRQDKRQVLKFLDSRIPHGVQWGDDWAALLAYRGSLLTDAPDERPPPARKHYARRPRAYDSHYMTYDS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -