Alyc040173.1
Basic Information
- Insect
- Agrochola lychnidis
- Gene Symbol
- -
- Assembly
- GCA_963680765.1
- Location
- OY796875.1:7159901-7194585[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 0.0011 2.5 9.5 0.1 18 64 347 393 335 442 0.86 2 4 0.00035 0.79 11.1 0.0 16 86 459 529 447 550 0.85 3 4 0.72 1.6e+03 0.4 0.0 59 107 619 669 600 680 0.74 4 4 2.8e-05 0.062 14.6 0.0 9 81 1012 1084 1006 1102 0.84
Sequence Information
- Coding Sequence
- ATGGTATATTTCAGGTTACCGAAGCAACCGGACCATTCTGCTGCATGGTTAGCAGCCGTAGCTAGACTGGGCTGCCGAATGAACATGTGTCTTGTAGTATGCTCTGAACATTTCCTACCTGAAGACTTTGATGACACTCGGCCGAATCAGCGAAGAGTCAAAAGTGGAGCTGTACCTAGTataGTGTGCAGAGTTTGTCTGGCTTTAGACGTCAAAATGTACAATATGAAAGAGTTTGGATTGAGTGAAATGTTCCAAAATATCACAGGAATATCGGCAATCGACAAAAAAGACAGTATACTACAGCGGGTTTGTTGGGAGTGCGCTGCGCGGCTCACAGCGGCTGCAGCGTTCAGAGACAAAGCGCTGCTCAGCGATGCATTGCTTAAAGACCAAGTTCACATCAAAGAAAGTGACATtgcattattaaaacaaaattacagttCTCTCAAATCACCTCTATCTGTTAAAACAACATTTAGTTCATATAATATTGAATGCGAACATACTATCTCTGAAAACAAAGAAATACTCTATGTTAAAAAAGATACAAAAGACAGAAAACCTGAAATAAGGATTATTGAAGAAGTAAAAGAGGTAGAATTTGAACAGTACGAGGCTTGGATAGATGTTCCTGTTAAAACTGAGATAGAATCAGATCCTATAGCTGATAATAATACGCAATTTCAAGATCGAAATAGCGACACATTTTTAGAACAAACACATTCTGATGATAGTTTCACTGATCCCAGAGAAGATAGTCAATATGGAGTAACAAATACTGAAGCACAAACTagtaattatgataaaaatataagagAAGATACCCAAAAAAAAGTTCCGTACATAAATGATGCTGGTAACATCGTTTTAGTagataagaagaaaaaaattaagcttgATGTGATCGATAAGATTGTGGACGAGACCTCGAGTGACGAAGACCTACAAAGTACAGTGGAAGTATCTGTCAATAATAAGCAAATGATTAGCAGTGAAGTTGGGGCTTCGAAGAAAAGAGGAAGGCGTTCTTACATGCTCAACGATaggataaaagaaaaaataattgcgTTAAAGAATAACGGTGTTCCTGTCTCCGCAATATCTAAAGAAACTGGAATGTCGacctCTTCTATTAGCTGCTGGTGGAGACGCTATCGCAAAAACGGTAACACGTACCGAAGGTCACTTGTTCCAGGGAGAGACCAAAGTGATACAAAACAGAATTATTGTTACAATCCGTCAGAACCTGGTAAAGAAATAGAGAGGTGTCCCACAATCGTGAGACAGAGACTGCGTGAAGCTGGGCTTGAACACATACTCATGAAGAAGCCAGAAAGAACTGTGAACATTGGACTAAAGACTAGttcGCGTAAAGCACTACATGAAGATTTAAAACAGCGTATAATAGCGCTGAAGCAAGAAGGAATGTCTAACAGCCGGATAGCTTACCTGTTAAATACTGCACGAAACACAGTACACAAGTGGTGGAATCGCTGGTGCAATGAAGGTCATATGCAAAACCACAAACAGCCTGGAAGGAAGAGGAAAACAACTCCTCAAGAAGACCAACTTCTAATAGAACGGGTGACTCAAGAACAAACTGTCCATACGCCGTCCCTGGCTAAGGAGTTTGGCATTTCTTTGAAgTGTTTAACAAATAGACTAAAGGAGGCTGGATTTAAAAACAAGACAAGGGAAGCCTACGTACCCTTGAAAGCGGGCCGGAGTCATAaGTTACCGAAGCATCCGGACCATTCTGCTGCATGGTTAGCAGCCATAGCTAGACTGGGCTATCGAATGAACAAGTGTCTTGTAGTATGCTCTGAACATTTCCTACCTGAAGACTTTGATGACACTCGGCCGAATCAGCGAAGAGTCAGAAGTGGAGCTGTTCCTACTATTATGGCTCCTGTTATCCAAGAAGAAATAAAGGTTATCGACCAAAAAGACAGTATACTACAGCGGGTTTGTTGGGAGTGCGCTGCGCGCCTCACAGCGGCTGCAGCGTTCAGAGAGAAAGCGCTGCTCAGCGATGCACTGCTTAAAGACCAAGTACATATAACCAAATATGACATcgcaacattaaaacaaaatcagcCATCTCTAAACTCACCCCTAACCGTTCAAACTGTATTTACTTCATCTGACAATGAATGCGAACATACTATATCTGAAAACAAAGAAatagataatatatttataattaatgaCAAGACAGTTATAAAAGAAAGGAAAACTAAAATAAGAATCAATGAAAAAGAGATAGAATTTGAGGAGTACGAGCCTTGGATAGATGTACCTGTGAAAACTGAGGCAGAAACTGATCCTATAGCTGAACACAATATGCAATTTCAAGATCTAAAAAGCGATACATTTTTAGAACAAACACATTTTAATGATACGTCTCCCAGAgaagataatgatgatgaagttaTAAATACAGAAGTACacattaataataaacaaataattttacgaGAAGATATTCAAAATAAAGTCCCGATCATAAATTATGGCAACATCATTTTAGTAAAAGACAATGAAAATATTGAGAAAAAACCAAAGCTTGATAAAATTGGTAATATTATTGATGAGTTCTCAAATGATAAAGACACACAGAGTGCAGTAGAAGCAGTATCTGTCAGTCAGACGAAGAAAAACATGAGCAGTAAGGTTGGGACAATGAAGGAAAGAGCTACTATCAGAAACAACGAGGGTTTAAAAGGAAAAATTATTGCATTGAAGAAAACAGGGCTTTCTGCTCCCGCAATAGCTAAAGAAACTGGAGTGTCGataacATCTATTTACGCATGGTTGCATCGGCATAACCGTAACGTCACAACATACCGGAGATCTACCACTTTAGGACGAGACCACACTATAGCAGACAGTGATTCAGAACAGGGTTGTTATTTGAACCCCGAAGCTGGTAAAGAAATGGGGGCGTGTTCTACGACTGTCAGACGACGGATGCGTCAAGCTGGGCTTGAACACATACTCATGAAGAAGCCAGAAAGAACTGCGAATATGGGGCAGAAAATTagcAAGCATAAAGCGCTCCATGACGATTTAAAACAGCGAATAATAGCGCTGAAGCAAGAAGGAATGACGAACAGCCGGATAGCTTACCTGTTAGAGACTTCACGAGATACAGTTCGTAAATGGTGGAATCGCTGGTGTAATGACGGACACATGAACAACCATAAAAGTActggaaataaaagaaaaacaacgcCTCAAGAAGACCAACTCTTAATAGCGCGGGTGGCCCAAGAGCAAACTGTCCATACGCCGTCTCTGGCTAAGGAACTAGGCATTTCTGCAAAGTAA
- Protein Sequence
- MVYFRLPKQPDHSAAWLAAVARLGCRMNMCLVVCSEHFLPEDFDDTRPNQRRVKSGAVPSIVCRVCLALDVKMYNMKEFGLSEMFQNITGISAIDKKDSILQRVCWECAARLTAAAAFRDKALLSDALLKDQVHIKESDIALLKQNYSSLKSPLSVKTTFSSYNIECEHTISENKEILYVKKDTKDRKPEIRIIEEVKEVEFEQYEAWIDVPVKTEIESDPIADNNTQFQDRNSDTFLEQTHSDDSFTDPREDSQYGVTNTEAQTSNYDKNIREDTQKKVPYINDAGNIVLVDKKKKIKLDVIDKIVDETSSDEDLQSTVEVSVNNKQMISSEVGASKKRGRRSYMLNDRIKEKIIALKNNGVPVSAISKETGMSTSSISCWWRRYRKNGNTYRRSLVPGRDQSDTKQNYCYNPSEPGKEIERCPTIVRQRLREAGLEHILMKKPERTVNIGLKTSSRKALHEDLKQRIIALKQEGMSNSRIAYLLNTARNTVHKWWNRWCNEGHMQNHKQPGRKRKTTPQEDQLLIERVTQEQTVHTPSLAKEFGISLKCLTNRLKEAGFKNKTREAYVPLKAGRSHKLPKHPDHSAAWLAAIARLGYRMNKCLVVCSEHFLPEDFDDTRPNQRRVRSGAVPTIMAPVIQEEIKVIDQKDSILQRVCWECAARLTAAAAFREKALLSDALLKDQVHITKYDIATLKQNQPSLNSPLTVQTVFTSSDNECEHTISENKEIDNIFIINDKTVIKERKTKIRINEKEIEFEEYEPWIDVPVKTEAETDPIAEHNMQFQDLKSDTFLEQTHFNDTSPREDNDDEVINTEVHINNKQIILREDIQNKVPIINYGNIILVKDNENIEKKPKLDKIGNIIDEFSNDKDTQSAVEAVSVSQTKKNMSSKVGTMKERATIRNNEGLKGKIIALKKTGLSAPAIAKETGVSITSIYAWLHRHNRNVTTYRRSTTLGRDHTIADSDSEQGCYLNPEAGKEMGACSTTVRRRMRQAGLEHILMKKPERTANMGQKISKHKALHDDLKQRIIALKQEGMTNSRIAYLLETSRDTVRKWWNRWCNDGHMNNHKSTGNKRKTTPQEDQLLIARVAQEQTVHTPSLAKELGISAK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00038838;
- 90% Identity
- iTF_00038838;
- 80% Identity
- iTF_00038838;