Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.7e-09 5.6e-06 27.1 7.6 1 48 53 101 53 107 0.90

2 2 0.057 1.2e+02 3.6 0.0 16 52 118 153 111 156 0.43

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.7e-09	5.6e-06	27.1	7.6	1	48	53	101	53	107	0.90
2	2	0.057	1.2e+02	3.6	0.0	16	52	118	153	111	156	0.43

Coding Sequence: ATGACCACTCCAATAATGTCCCAGCCGTCTTTTGAGTCATCACAGACAAATGCTGACATCTACATTGGTTCGTATCACAACGGTGTGGCTCCATACGGCCCCCCAGTGATCCTAGGGCCCATAGTGCCTTCGACATCTGGACCTAAACCCGTCGGTCCCCAACCCACCTTCATCACATGTCATATGTGTAACCAGGAGATAAAAACTGTCATCTTCCACAGGCCTACAGCGAAGACGCATCTCTTAGCATGTTGCTTGTTTATGTTCGGGAAAGATGTCGAATGTACCTGTAGGCCCCGAGCCTGCTCGCACCACCTGCCCATCATGCGGAGCTACAATCATGACCAGAGTAGAACGGACGGCCACCACCAAGACACATCTGATTGCTTTGCTGCTCTGCTTGTTCTTATGCTGGCCATGCGTGTGTGTGCCGTATTGTATGGATTCATGTCAAAATGCGACGCACTACTGTCCTAA
Protein Sequence: MTTPIMSQPSFESSQTNADIYIGSYHNGVAPYGPPVILGPIVPSTSGPKPVGPQPTFITCHMCNQEIKTVIFHRPTAKTHLLACCLFMFGKDVECTCRPRACSHHLPIMRSYNHDQSRTDGHHQDTSDCFAALLVLMLAMRVCAVLYGFMSKCDALLS

Sequence clustering based on sequence similarity using MMseqs2