Basic Information

Insect: Agrilus cyanescens
Gene Symbol: MBD-R2
Assembly: GCA_947389935.1
Location: OX376705.1:31216061-31219530[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 8.6e-15 8.7e-11 42.7 0.1 8 72 366 429 364 434 0.91

2 2 2.9 3e+04 -3.8 0.0 31 44 481 497 474 500 0.76

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	8.6e-15	8.7e-11	42.7	0.1	8	72	366	429	364	434	0.91
2	2	2.9	3e+04	-3.8	0.0	31	44	481	497	474	500	0.76

Sequence Information

Coding Sequence: ATGGGTCGTCGTTGCTACGTACCTGATTGTACATCGGAAGAAGGTAGAGAAGAACATCAAGGTGTAACTTTTCACAAGATTCCGATGCACTCTGACATACGTCCAAAGTGGATGTCGCTGTGTCATATACCGGGTGATAAGAAGGATATGAAAGTAATTTATATTTGCTCCAGACATTTTTTGAATGCCGATTTTTGCCATTTTAAAGGTAAAAAGTACATGTTGAAACAGGGAGTTTTGCCTAGTGTGTTTCCTTGGAAGAAAACCATTCCAAAGAAAACGAAATCAAAGAAGGTTAGTTCTTCCAATACTTCATCTGCAGAAGGTGAAGATAATGTACCAAATGCTGCAACAAATGAGATCAAAGAGGAAGAAGTTTCTATTAAGATGGAACCACTTTTATCAGCCAGTGAAAGTTTAGCAGGTTCTGACCAATGTTCAGTCTTGTCACCTGGCACTTCCAATCAGTCAATAAAAGAGCAAGAAAAAATTAGTGCTTTTACACCTAATATGCATATTGAGGCATTGGATTTTAATGAGGTGTGGTATCCAGCACAAATTGTTGAAGTCGATTATGAAGAAAGTGAAGTTCTAATACATTTTGATAAATATTCAAGTAAATATGATGAGTGGATATCCATGAACAGCTCAAGGCTACGCCCGGTGCAGAAGAAAGAACCTGAAAAGTTTTCTGTTGGTGAAAAGTGCCTGGCTTCATGGAGTGATGCTCGGAAATTTCCTGCAACTGTTACAAAAGTATTGAATAATGGTGCTTATGAAGTCATATTTGATGATGGTTTTGTAAAAACATTAAAAGTACATCGAATGGTAAAAGTTGATGGGAAACACCTTCAATCGTCCCCGCTGTTTGATCCAATTAAAAGCACGAAACAAGAACGACGTGATCGCAAACGTAAACTAAACGTTGCTGCATTATTTGGAAAACGTTCAAAGCCCCTTGACGCATCCGAAGAATCGGCTCCTCAAACGGAAGATGGAGACATTTGGATACCAAAATGGGAAAACGGAAAACCTGTGGGTGAAGAATCATCAATCGAAATGAATGACGGCGCCAGAAAGTCATTTATCATACCTGATCCACGATTACCCCCAAATTGGGTGAAACATCTGACTCAACGTCCCCACGGTTCATCTGCTGGAAAATGGGACACTGTTATTGTCAATCCCGAAGGCAAGCGATTTCGAACCCGAGCGGAGGTAAAAACGTGGTTAGAAACTCACCCAAATTGCAATCTCTCAGAATACAAGTTCGACTTCAGCCTCCACAAAAAGACGCGACGTTCAACGCAGGTACCTGCGTCAACATCGGAATCAGTCGTCAGTCAAACAAGCACCGAAGGTGCCGTAGCGCATTCAGAAGAGCACGATTCGGCCCTTGAAGCAGAAAATGAAATAAAAAATAACTTGAAAATAACGTCAGTAGACGGAGTGTATCAGTGTCCCATTTCAGGTTGTGGTAAGAGTTTTCGTCGTGAAAATCTCGCCCAGATGCACGTGAAACATTACCATCCTGAATACACCAAATATCTCGATTCGACACCTAACGTGGCGGATTTGGCGTACGCACGAACCGTTGGCGAGAATCTTCCCGAAAGAATCGAAAAATTGAAACAGACTCCGGTAAAGAGTCAGACAACAAAAAACACTCCTTCTAAAATTAGCAGTTCACTTCCACCGCAGCCGACAAAAAACGATAGCGAACCTCCTCAGCCTGTCCCTGCCGAAGTCGATAACGAAGACAAAACGAAAATTAAAGAGGAAACAATGTCTGTCTTAAAAGACTCTGAGATTCTTAAATTGCTTAACACCAAACCTTCAGTGGGAAGCGTAGCCATCAAATACCCACCTGGATTACCTCCTAACGCTTATCCTGATATAAAATTAAAGGACCTTTTGAAAAAATCGGACGCCGTGCCATGTAATGTTAACGATTCTAACTCGGCGTCTTCGTCGGGTTCCTCTTCGTCGTCAGCCGTTATTGCTAACAAATCAGGCATCAAGACGTTACTTCCCATCGTTAAATGTGAAAATATTAAAAAGGAAAGCGACAACGGATACGAAAACAGCAATCAGACTCAAAATTTTGAAACAAACGAATCGCATGTTTCTGAAACAGACTCTAAACAGCCAGAAAATACGCCGGCATCCGAATCTAATTACATTGTCGAAGGCGGTGAGGTGATAAAAATCGTACAAATGAAACGGGAAGAAATAATTAATTGCACATGTGGAATAACCGAAGAAGACGGTCTTATGATCCAGTGTGAGTTGTGTCTGTGTTGGCAGCATGCTTATTGTAACAATATCGAGAAGGAAAATCAAGTCCCGGATAAATATATTTGCTACATATGTCAGAACTCCACCAGGAGCAGGTCATCCAGGGTGTATTATCACGACCAAGACTGGTTAAAGCACGGCGTTCTCGCGGTCGGATCGTATCATTGTAAAGACGACGAGACGCTCTTCAAGAGGTTTGAAAAGCTCAAAAAAGCTCACGATTATTCTGGCGCTTTGATCGAATTAAAGAATTATATACATGCACTTCGGATAAAATTAAAAATTGCAGAGGCTAAAAATCATCCGAAGCTGTATCTGTGGTCAAAACCGTGGTTAAAGTGTTTGCCCGAAGTAATCGAGAAAAAGGAACAAGATGAACACACTGTTGCTAATTCCCACGACGTCCAAAAAGAGAACAACGAAAATGATACTTCATCTTTCGAATATCTCGCCAACAGTTCGGTGTTATTGTCTATGCTCAAATCAAACAAAAAGGAAGAACCTTTAGCAACTGATAACATGTTAGATTTGGACGTTGGAGGTGTGAAAGTGCCGCAGCCTGAAGCTGCAATCGATTCGTCGGAGTGTCGTTTGAATCTTCTCGATCACATCAATTTCGGACAAAATCTAGTGGAAGCGAGACTTGACCTTTTGGAAGAGAAAATGAAATATTTCGACGTTGCGGGTGACAGCGAAGAACGAAACCCTGTACAAATTTCGCGTACAATACAAATGCTTCTGAGAGACCTCGTACTTCTTCAAGATTTTGCTCAAAGCAGCAGCCTCTAA
Protein Sequence: MGRRCYVPDCTSEEGREEHQGVTFHKIPMHSDIRPKWMSLCHIPGDKKDMKVIYICSRHFLNADFCHFKGKKYMLKQGVLPSVFPWKKTIPKKTKSKKVSSSNTSSAEGEDNVPNAATNEIKEEEVSIKMEPLLSASESLAGSDQCSVLSPGTSNQSIKEQEKISAFTPNMHIEALDFNEVWYPAQIVEVDYEESEVLIHFDKYSSKYDEWISMNSSRLRPVQKKEPEKFSVGEKCLASWSDARKFPATVTKVLNNGAYEVIFDDGFVKTLKVHRMVKVDGKHLQSSPLFDPIKSTKQERRDRKRKLNVAALFGKRSKPLDASEESAPQTEDGDIWIPKWENGKPVGEESSIEMNDGARKSFIIPDPRLPPNWVKHLTQRPHGSSAGKWDTVIVNPEGKRFRTRAEVKTWLETHPNCNLSEYKFDFSLHKKTRRSTQVPASTSESVVSQTSTEGAVAHSEEHDSALEAENEIKNNLKITSVDGVYQCPISGCGKSFRRENLAQMHVKHYHPEYTKYLDSTPNVADLAYARTVGENLPERIEKLKQTPVKSQTTKNTPSKISSSLPPQPTKNDSEPPQPVPAEVDNEDKTKIKEETMSVLKDSEILKLLNTKPSVGSVAIKYPPGLPPNAYPDIKLKDLLKKSDAVPCNVNDSNSASSSGSSSSSAVIANKSGIKTLLPIVKCENIKKESDNGYENSNQTQNFETNESHVSETDSKQPENTPASESNYIVEGGEVIKIVQMKREEIINCTCGITEEDGLMIQCELCLCWQHAYCNNIEKENQVPDKYICYICQNSTRSRSSRVYYHDQDWLKHGVLAVGSYHCKDDETLFKRFEKLKKAHDYSGALIELKNYIHALRIKLKIAEAKNHPKLYLWSKPWLKCLPEVIEKKEQDEHTVANSHDVQKENNENDTSSFEYLANSSVLLSMLKSNKKEEPLATDNMLDLDVGGVKVPQPEAAIDSSECRLNLLDHINFGQNLVEARLDLLEEKMKYFDVAGDSEERNPVQISRTIQMLLRDLVLLQDFAQSSSL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00031121;
90% Identity: iTF_00031121;
80% Identity: iTF_00031121;