Basic Information

Gene Symbol
Hr39
Assembly
GCA_951799405.1
Location
OX637345.1:11606052-11617269[+]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 2 2.6e+04 -8.0 9.2 97 138 207 263 97 333 0.40
2 4 8.8e-08 0.0011 18.9 0.1 1 19 431 449 431 455 0.94
3 4 0.022 2.8e+02 1.2 0.0 97 138 488 534 451 547 0.72
4 4 6.6e-68 8.5e-64 217.0 0.0 205 408 558 764 550 764 0.92

Sequence Information

Coding Sequence
ATGCTGGCGGCGCCGGGCGCTGCGGGGGACGCCGCGCACGCCAAGAACGTCTCCGTCACCACCATCAACATGAGCGACACACCGCCAATCACCAATGGACAGCTGACTTACAGCGCCAACGGTGTCCGCATCAGCGTGGCCTCCTCCGGAGCCGCTGCTGCAGGCGGGTGTGGAGGGGGGGGAGGTGGACCACCAACTCCCCAGCAGAACGCCCCGACATGGCAGGACGAGGACTCCAACGATGCCGAGGTCTCCAACATAGACTTCTCCCATCTGCCCTATCAGGTGAACATGCGCACAAAGAAGAAGCGCCCCTCCTCCAGTAGTGCCGCCACCGAGGTGGACGGCGACAGGGAGAGGGAGAGGCCCATGTCCTGGGAGGGCGAGCTCTCTGACTCCGAGATGCTGGTGGACCAGGAGGCCACACCCACgctgcagcagcagcagcgCAGCCACAGCATGAACAGAGTTTCAGTTTTGGCTGGAGACAGCTTACTGGAGAAGTCATCTGAGGAGTCTGGAGGAGCATCGGAGCAGGTGATCAAGAACATACCCTCGGCCATCATCCCTCAGGCGCTGAGCACTAAATTGGCCACTGAGGCCCAGGCATTGGCGTGTAGAAGAGAACAGATGTGCCATAAACCTGCAGAGGGGAAGCCGGAGCTGCCGCTGCTGGTGGACAAGCTGCTGAGCGGCTACTCGCTGCACAGCACGCCCAGCAACTCCCCGCTGCTCACCCGCCACCACAAGATCCTCTCCAACCCCAGCAGCGACTCCGCCATCCACTCCATATACACACAGAGTGTGTACAGCAGTCCAGGGGCCAGCCCGGGCGCCACGAGGCACGCGCCCTACACACCGTCGCTGTCACGCAACAACAGCGACGCGTCGCACTCCTCGTGCTACTCCTACAGCTCCGAGTTCTCGCCAACGCACAGCCCGGTGCAGGGCAGGCACACGCACGCGCATGGGCACCCGCACGCGCATGCGCAGCACGTACGCCAGGGGGACGCCAGCCCTGATCCTGATGACAGGCATCTGCACCATCAGGGGGTCAGCCGGCAGCAGCTCATCAATAGTCCGTGCCCCATTTGCGGGGACAAGATCTCTGGCTTCCACTACGGCATCTTCTCGTGCGAGTCGTGCAAGGGCTTCTTCAAGCGCACGGTGCAGAACAGGAAGAACTATGTGTGCCTGCGCGGGGCCAACTGCCCGGTGACTGTGGCCACCAGGAAGAAGTGCCCCGCGTGCAGGTTCGACAAGTGCCTGCACTGCGGCATGAAGCTGGAGGCCATCAGGGAGGACAGGACCAGGGGCGGCAGAAGCACGTACCAGTGCTCCTacagcctaggcacgctgagaCACGCCACCAGCCTCAACTCTGTGAATGGTCCAGTCTCGCAGTTCACTTACCGCTCTCAGCAAGATCTTCACGTGGGTCTGATGGCCGTCAAGGCTGAGCCTATGTACGGCGACACCAGGAGAGTTCCTCCGTTACTGCAGGAAATCATGGACGTGGAGAACCTGTGGCACTACACTGCCTCGGAGCTGGTGCGCCTCAACAAAGGAGAGTCCCCTGGATCGGGACGGTCGGCATCGTCTGCCAATTCCGGGGCCGGTCCCTCGCTGGTCACCAATCCTCTGCTGAGAGCGGCCGGTGTTCCAGCCGACAGCAATCCAGACTTCCTGGCAAATCTGTGCAACATTGCAGACCACCGGCTGTACAAGATAGTCAAGTGGTGTAAGAGCCTGCCCCTCTTCAAGAACATATCGATAGACGATCAGATCTGCCTGCTCATCAACAGCTGGTGCGAACTGCTGATGCTGTCGTGCTGTTACCGCGGAGTACGCACACCTGGCGAAGTGCTGGTCGGTGGAACGGGGGGCGGGGGCGCCGGAGGGGGCATCACCCTGCAGCAGGGGGCCAAGCTGGGGCTCACCCCCTGCATAGAGCGCATGCTCCACTTCACCGACCACCTGCGGAGACTGCGAGTTGACAGATTCGAGTACGTGGGGATGAAGGTCATTGTGCTGCTCACGTCAGATACTTCAGAACTGAAGGAGCCAGAGAAGGTGCGGGAATCCCAGGAGAAGGCCTTGCAAGCTCTCCAGGAGTACACACTGGCCCACTACCCTGACATGCCCGCCAAGTTTGGGGAGCTGCTGCTCCGCATCCCGGAACTGCAGCGCACATGCCAGGTTGGTAAAGAGATGTTGAATCCATCCAGCAAGTCCAAGGATGGAGAGACTCCGAGCTTCAATCTGCTGATGGAACTGCTGCGAGGAGATCACTGA
Protein Sequence
MLAAPGAAGDAAHAKNVSVTTINMSDTPPITNGQLTYSANGVRISVASSGAAAAGGCGGGGGGPPTPQQNAPTWQDEDSNDAEVSNIDFSHLPYQVNMRTKKKRPSSSSAATEVDGDRERERPMSWEGELSDSEMLVDQEATPTLQQQQRSHSMNRVSVLAGDSLLEKSSEESGGASEQVIKNIPSAIIPQALSTKLATEAQALACRREQMCHKPAEGKPELPLLVDKLLSGYSLHSTPSNSPLLTRHHKILSNPSSDSAIHSIYTQSVYSSPGASPGATRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPVQGRHTHAHGHPHAHAQHVRQGDASPDPDDRHLHHQGVSRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCLRGANCPVTVATRKKCPACRFDKCLHCGMKLEAIREDRTRGGRSTYQCSYSLGTLRHATSLNSVNGPVSQFTYRSQQDLHVGLMAVKAEPMYGDTRRVPPLLQEIMDVENLWHYTASELVRLNKGESPGSGRSASSANSGAGPSLVTNPLLRAAGVPADSNPDFLANLCNIADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLMLSCCYRGVRTPGEVLVGGTGGGGAGGGITLQQGAKLGLTPCIERMLHFTDHLRRLRVDRFEYVGMKVIVLLTSDTSELKEPEKVRESQEKALQALQEYTLAHYPDMPAKFGELLLRIPELQRTCQVGKEMLNPSSKSKDGETPSFNLLMELLRGDH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00023867;
90% Identity
iTF_00023867;
80% Identity
iTF_00023867;