Basic Information

Gene Symbol
-
Assembly
GCA_951799405.1
Location
OX637333.1:11109331-11140001[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2.7e-16 1.7e-12 47.2 0.1 6 71 235 298 232 302 0.89
2 3 0.27 1.8e+03 -0.8 0.0 30 57 425 451 415 475 0.74
3 3 1.9 1.2e+04 -3.5 0.0 48 60 501 513 499 520 0.78

Sequence Information

Coding Sequence
ATGGCAGACGAGCCGCTGAGTTTTAGTGACGTGCAATTTTTAAACGGCGAAGCGCCCGAGGAAACCGAGTCGCCGAAAATTGAAGAGAAATCTGTCCTTGTAGCGGTAGAAGAAAATGGTGATGCCAAAGACGATACGAAGTCTGTTGAGATTCATGAAATGAAAACAGTCGTAAACGATGGATCTACAAAGGAACCTGAAACAGAGAAACCTGATGATAAAAAACCTGAAGAAATAATAAAGAAAGAAGATGAAGAAGTTAAACGAGAAGATTCCGAGATGGCGGAGGTCCCAGCCTCCAATGACAGGAAGCGCAAGGCCAGCGAGTCCTCTCAGGACTCGGACTTTGCTGGTTTCGAGCCTCCCGCGGAACTTCAGGACATCAAGATCAAAAATCTCTCAAAACTGATAAataaaataaGCAAGGAAACAAAAGAATCTGATGTGGGTTGGTCCAAGTTTTCAGCCATTCTCAAAAGAAACGCACTTGACTCTCCTGCTCATTCCACAGATGAACCGTCTCGTCCGTCCTCAGGTTTATCCTTCAGATCGGAGAGTGAACTGATGGCTGTCAACTACTCGTCTACGGAGTTGGGCAGTTCGGCAGCCAATAGTCCCGTCCCCGTGGGCACGCCGGCCGGAAATCGCGGCGGCCGTGCCTCCCTGGGAGGGCGCACCTCCAGCCTGGACCTCAGCAGCCCGCAGTACCGCGCGCCCATGGAGCGCGGCTGGAAGAGGGAGCTGGTGTACCGCGCCTCTCTAGACAAGCAGGGCCGCCGCCAGGGCGACATCTACTACTACTCACCCAAGGGGAAGAAGCTCAGGTCCACAAGAGAGGTGTCGGAACATTTGTCAGATAACGACCTCACCATTGAGAACTTCACATTCTTCAAAGGACCTCTGGGGCTGGATGATCCTGACAAAGAAATTATCAGGAATGCCAAGATAGTAGCCTCCTCCACCATGGTGAGTGCCGCGCCTGCTCCGGCTGTCCCCGCAGCCCCTCCAGCTGTCCTGGGGAAGAGGACCCCCAAGCCCAAGGGACCCAAAGGGGCCTCACCCGAGAGGGGAGTGTCAGCCACTCCTAAGATCAGACCAATCAAGAACATCAAGCTGAAAGCCCGAGTCAGTCCAGCCAAGTCTTCAAGCCCGTCTCCGCTGTCCGAGGAGGCTCCACCTGTCCTCACCTCAGCTCCGCCTGCTGAAGGAGCTGCTAAACCCACACGCAAGTCCCTGGGCCTGGTGGGCAAGAAGAAGCGTGTTGGGGAGCAGCGACCACAAGTTGTGATGTACACGCCCATGGGACAGAGGCAGCCGGACTCGGAAGTCAACAAGTACTTTGATCAGGCTGTTAAGACTTTTGGCACCGACACTACAACCAAGatGACACGTGAGCTATGCTCAGTCCATTGCCCCAATGCCAAAGGTGAAGTCCCGACCATGCAGTGCAGTCTGTGCAGATGCTTGTATCACGAGACATGTGCGGGCATGCGACAGGCGGATCTCGTGAGATACATCTGTAAGAACTGTCAGACATCCAGTCCTGTGAAGCTAATGCCTCCCCAACTGACGCAGGCACCGACGATAAAGCCTCAGATTCGCGGTCCCCCTCGGCCCCCTCCACAACTGACACCGCAGCCGCGGCAAGCCTTCAAACTCCTGCCACAACCACGACTCATTCCTGTCGTCAGGCGAGCACCACCGCCAAACAAGCTCACCACAATCAGGAAACTAAACTCTGAAGACATCATCAATATCAACAAAGCCAACAGCGATCCAAACAAACCTAACTTTAATATGAAGAGCGTCATAGGATCTGTTACTACATGGCTACCACCGAGCTCAACTATCAGAATGGGAGGACCGAAATCTGCAAAAAATCCTGCCAATATGCAGATTTTAAACAATATGATGAATCCACCTCAGACCATTGCAATTCTAAACGGAAGACGGTATATTATAGTTCCTAAACACAGCGTGATGAATGTGACATCATCAAATGCAGGGGGGGCTGCTGCACTCAAACAGACGGAGAACGCTCCAAAGATTGACAGTGCTGGGGATGGGGGGGAAAAAAGCGAAGAGGCTAAATCAAATGATGAAGTGAAGGTGAAAGATGAAAGTGTTGATGGAGATATGGATGTGGATGAAGGAGAATCGATTGAGGCGGAGGAGAAAGATCTGGGAGAAACTGAACAAATGGAAGATGATACTAAGAAGAGAAAATTGTCTGAGATTGAAGAATCTCCATCTGCGACTCCCAAAAAGAAGTTGAAATCTTCAGACACACCCAAGACAACAATGACTGCTGAAAACGGGAACGATGGCaagtttttataa
Protein Sequence
MADEPLSFSDVQFLNGEAPEETESPKIEEKSVLVAVEENGDAKDDTKSVEIHEMKTVVNDGSTKEPETEKPDDKKPEEIIKKEDEEVKREDSEMAEVPASNDRKRKASESSQDSDFAGFEPPAELQDIKIKNLSKLINKISKETKESDVGWSKFSAILKRNALDSPAHSTDEPSRPSSGLSFRSESELMAVNYSSTELGSSAANSPVPVGTPAGNRGGRASLGGRTSSLDLSSPQYRAPMERGWKRELVYRASLDKQGRRQGDIYYYSPKGKKLRSTREVSEHLSDNDLTIENFTFFKGPLGLDDPDKEIIRNAKIVASSTMVSAAPAPAVPAAPPAVLGKRTPKPKGPKGASPERGVSATPKIRPIKNIKLKARVSPAKSSSPSPLSEEAPPVLTSAPPAEGAAKPTRKSLGLVGKKKRVGEQRPQVVMYTPMGQRQPDSEVNKYFDQAVKTFGTDTTTKMTRELCSVHCPNAKGEVPTMQCSLCRCLYHETCAGMRQADLVRYICKNCQTSSPVKLMPPQLTQAPTIKPQIRGPPRPPPQLTPQPRQAFKLLPQPRLIPVVRRAPPPNKLTTIRKLNSEDIININKANSDPNKPNFNMKSVIGSVTTWLPPSSTIRMGGPKSAKNPANMQILNNMMNPPQTIAILNGRRYIIVPKHSVMNVTSSNAGGAAALKQTENAPKIDSAGDGGEKSEEAKSNDEVKVKDESVDGDMDVDEGESIEAEEKDLGETEQMEDDTKKRKLSEIEESPSATPKKKLKSSDTPKTTMTAENGNDGKFL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-