Basic Information

Gene Symbol
RREB1
Assembly
GCA_951802165.1
Location
OX637697.1:21685458-21690199[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.00031 0.042 15.5 1.2 1 23 61 83 61 83 0.98
2 16 0.00036 0.048 15.3 0.4 1 23 96 118 96 118 0.98
3 16 0.00019 0.025 16.2 5.1 1 23 124 146 124 146 0.97
4 16 1.2 1.6e+02 4.3 0.2 1 23 207 231 207 231 0.87
5 16 7.9e-05 0.011 17.4 1.7 2 23 237 259 237 259 0.97
6 16 2.7 3.6e+02 3.1 2.5 1 16 305 320 305 325 0.83
7 16 0.23 30 6.5 0.1 1 23 456 478 456 478 0.96
8 16 8.9e-06 0.0012 20.4 0.8 1 23 487 509 487 509 0.99
9 16 0.00091 0.12 14.1 3.1 1 23 515 538 515 538 0.97
10 16 0.00054 0.072 14.8 3.0 1 23 938 961 938 961 0.97
11 16 0.00054 0.072 14.8 0.4 2 23 1175 1196 1174 1196 0.97
12 16 0.14 18 7.2 6.3 1 23 1202 1225 1202 1225 0.97
13 16 0.051 6.7 8.6 2.5 1 23 1253 1277 1253 1277 0.95
14 16 0.075 10 8.0 1.2 1 23 1336 1359 1336 1359 0.95
15 16 0.018 2.4 10.0 0.4 3 23 1406 1426 1404 1426 0.93
16 16 0.0089 1.2 10.9 5.7 1 23 1432 1454 1432 1454 0.98

Sequence Information

Coding Sequence
ATGGAAGTATCTCCTAGTCCAATGAATTACTCAACCAAAGAAAAGACAGACCAAAGCAACCACGATTCCGGCGTGTTCTCAGCGACCAACAACTCGATCTACGAAGAACCCAGTCGGATGACCCAATCAGAAAACTGCCCTTCCGAGAACGGAAGCGACTGCAGCAGCATCTCGGACAGGTTCTCCTGTCCCATATGCTCCACGGTGCTATCTTCCCAGCACGACTTCACGCTGCACATCAAGTCCCACAACAGCGACAACGAAACGTTGCAAGACGACAAAGGGTACACGTGCAGGATCTGTTTTAAGGTTCTCAGTTCCAGTTCAAGCTTAGACAGGCATGTCTTGGTGCACAGCGGGGAGAGACCCTTCCACTGCAAGTATTGCGGCGATACTTTCACCACCAACGGAAACATGCACCGGCACATGCGAGCTCACTCTATAAAAAGCAAGAACTATGAGTCTGACGGAAGTACTGATAGCAGCGCCAGCAACACCGAATACAATAACAACAGGATTAAATCCAGGGTGTGCAGAAAACGTAAGCTTGAACAAGATGACGAGGAGATCACCAACAACAAAAGATCCTCCAACTTCGCTGAAGATATTCCTGGAGCTTACAGATGTCCAGTTTGCGAGAGAAAAGATTTCGATTCCTTCTCCATACTGGAGAACCATATGGAAGATAACCACCCAGATTACCCTGCCAAGTGTCACCAGTGCGGCAACGTTTTCTCCAACCAAAAACAATTGATGGTACATCGTGCTACTGTGCATGAAAACGTTAACCACAAGCATTCAGTCGTTGGATTCAAAGACCTAACCTTCGTGGACTTCTCCAGCGAGAAATTTCCGCACATCGCTCGTTACGAGTGCGAGAAGAATCTACACAAAGGGTCGGGTAGTATGAAGTTCCAATGCAAGAAATGCAGCCGAGCGTTTCCTTGCTCCAGCTCTCTGGAATTCCACGAGAAAGACTGCAAAGAAAGCAGCTCTGGGTTAGATCTTTCCTCTCAGAAATTATCAGAGGTGGAAGTCAGACGTAACGACTTCTTCTCCCGTTTGAATCTCCAAGATATATCACCTGAAAAACATATCCCCAAAAAGAATGAACAAGACAAAACCGTAAAGAACGAGTACAGACTACTCCCAGATAACAACAAGGACTTGGCAGACATACAAACCATCATATCCATGACGACCAGTGGAAGCTTACTGCAGCAACTCCAACATAAAACCAACGAAATAACCAACAGTCTCCAAGTGTCAAACCAGGAAATCAAACAAGAATCCTCGAAAAACGAAGAAGAAGAAACGCAAGACGCTTTCGCTGTAGAATTCCGAAAGATGAAGCTGAAAGGAGAGTTTCCCTGCAGACTCTGCACCGCCATCTTCCCAAACTTACGAGCTCTGAAGGGGCATAACAGGGCGCATCTTAATGGGAACAACAACGGCTCCTATCGCTGCAATATGTGTCCACATTCCTCAATAGATAAAGCTGCTCTGATACGTCATATGCGTACCCACAACGGTGATCGTCCATACGAATGTTCCTTGTGTAATTATGCCTTTACCACCAAAGCCAACTGCGAGCGTCATCTTAGGAACCGTCACGCTAAAACCACCAGGGAGGAGGTGAAGAAATCCATCATTTACCACCCTTCAGAAGACCCTACCAATGACGAGATGACCAAATTGACCGCTAGAGAAGATTCCAGAAAGTCACACAATTCTTCCAATGAAGTTTTCGACTACGTTCCAGATAAAATACACTGCTCAACGCCAAAATTCGAAGTGAGACCTGAGCTGAAACATATCACCACTCCTGAACGAAAACCTTTACTTTCCAACTTGCAATCCCTCAAAGAGAGTCTCAGTCTGTCAGTGGGGAAAGAACCAATGCAGTTATTCCCGAACATAAACGATGTTATCCGAAACGAAAACCTGAAAAGTCTTAAGGAGTACAGAAACTCTCATAATGGGACCATTCCAGTACCTCCTTACTTGCCTCCCTACGGCTTCCAACCTAAATTGAACGCAGTTCCTTCTCCTGGACAAATTCAGGTCAAAGATTTGAGCACTTTGAAAATGGATCCTTACGAAAATAATTCGGACGAAGACGACTATGAAGACGACGATGATTCCATCGATGTTGTATTGGATTTGAGCAAGAAGAAACCCACAACGGAAGAACCAAAACCAGTAGACGATGCCCCGCAAGATTTATCAGTCAAATCTTCCCCGACATACCCTCAAGTACCGCCGCCTGTTGCAGAGATGCTCCAGGCAAATCTGCTCAAAACTCCGCCAAAGATCGACCCTGCAGCTTTCTACGCACAATGGGCTCTGCTGAGAAATGGTTTCGCGGGACTGCCAAGTTGGCCAAGCTTTCCTTTCAACCCGCTTTTCCTCCAACAACTCCAAAACCAAGTGCCAACAGGAGCAGCTGCTGACATGAAAGACAGGCTGAGGAATCAGCTCTGCGGGGGAACGATCATCGCAGACAATCGTTTGCAAGCCTTACAGCAGATCAGAAATGCTGGTTTGATGCCTATGGGCATGAATAACTTCAACAGCGAACCTAGACAAGAGGTTGATACTACATACTCCCCTCAAAACACTCAAGAGGATCTCAGTAAACCTTTAAGTCTAAAAATTGAGCAAAGCATGAACGAGAGTATGTCCAAGATGGCAAGTCCTCTATCACATAAACCAGATATAATGCAATCGCCAAACTCCGTCAAGATGGTCATCAAGAATGGAATTCTGATGCCCAAACAAAAACAGAGGAGATATCGAACTGAAAGACCTTTCACTTGCGAACATTGTTCCGCCAGGTTCACCCTACGTTCAAACATGGAACGACACATCAAGCAGCAGCATCCTCAGTTCTGGTCCCAACGCCAAAGAGGCAACATCGGTAACCCTGGTAGAAAATCGCAAGTGATGCAGATGAAACCTGGTTTTTGCGATCTGAGCATTCCCAACTACGAAATACAGAAAAATCAAGTTTACGAGGACAACAAAGAAATGCTGAGTGACAGACTCAAGTTTGCGATTCTTGCCCAACATCTGAGAGGAGTTAACAACTATAACCACGCCATCAAGAGGGAGGAGGAAGAAGAAGATAATTTGGTTATAGATGAAAACTGCGAGGAGAAGCCTACTGATCTGGAAATTGCGGAATCTTTCGAACAAGAAGATCAAGAAGAAGACGAAAGAGAAGAATCTCCCAAAGAACAAGCTTCGTTCGAAACCAAAAGCGGCAAATTAGAAGAGAGTCAAGACTTAGTACCAGTCTCCAGGCTGTTGGACAACGCGTCACAGCAACAGTTCAATGAGTACTTCAAGAGAGACGTCGAAGACAATGGTGCTGGTAGTGAAGAAGATGAGGAAGGTCTGGTGGCCAGTGGAAGTACCAGCGAAGGGAACATCTCTGGCACCGATGAAAATAAGTCTGAATCAGAGAACACAGCTCCGGTAAAGAAGAAGTCGGCCTATTCTCTAGCCCCAAACAGGGTGAGTTGCCCATACTGCAGTCGCAAATTTCCATGGACATCATCCCTACGTCGCCATATCTTAACCCACACAGGCCAAAAGCCCTTCAAGTGTAGCCACTGCCCTCTCCTATTCACCACCAAATCCAATTGTGACAGACACCTTCTGAGGAAACACGGCAACGCTGCCACTACCATCACCAACGATGTGGTCAACAACAACTCCAACTACTTGATGAGGAATGTTCCCGAGAGACCCTTCAAGTGTTCCAGCTGTCCTAGCAGTACCTTCTCCACCTATACCAACTTGAAGAAACACATAAGTTCGAAACACGCCACGAACGCCCAGGGTGATGATATAAGGGCTCAAGGGTACGAAGCTGGTAGCTCAGAAGACGAGAAGATCGTCCATGTTTCCGACAACATCAACGAGTGGAACAACCAAAACTTGCAGACTAAAGTACCCAATCATGAACCGTTACCGAGTGTGGTCAACGCTGATCAACCTTTCAAATGCCATTTATGCGAGTACTCTTTTGGGGAACGCCAAGAAGCTTTGGACCACATCAGAGACAAACACGCATCGGAGTACGATTTGTTGATGTCCAAAAACGCGTTGGACAGCAGCGCAACTACACCGGAAGAAAGCGCACATAACGACGAAGAAGACAGCGAAATAAGAGGAAAATTTCCTGATTACTCCAACAGAAAGGTTATCTGCGCTTTTTGCATGCGTCGCTTCTGGTCCGCTGAAGACCTGAGGAGGCATATGAGAACCCACACAGGGGAAAGACCGTTCATGTGCGACATCTGCAGGAGAAGATTCACGCTAAAACACAGCATGTTGCGTCATAGAAAGAAACATAATGTGAACTACGATAATGACGCTGCCATGAATAGCGACGATGATGGTGTGTCTCCAAAGTATGAAGCAGGAAACAACAACAAGAGAGCTGAAGATTCCGACTGCAATGAAGGAGGAGATTTAATCAGTAATCTGCTTGGAATTCGCCCGTCCTTCATCGATAAAGTTCTGACAGCATCGGCAGATGACGCTGCTAAGCTTCTAGGTGTCAAAAATGGTGTCAAGGAATAG
Protein Sequence
MEVSPSPMNYSTKEKTDQSNHDSGVFSATNNSIYEEPSRMTQSENCPSENGSDCSSISDRFSCPICSTVLSSQHDFTLHIKSHNSDNETLQDDKGYTCRICFKVLSSSSSLDRHVLVHSGERPFHCKYCGDTFTTNGNMHRHMRAHSIKSKNYESDGSTDSSASNTEYNNNRIKSRVCRKRKLEQDDEEITNNKRSSNFAEDIPGAYRCPVCERKDFDSFSILENHMEDNHPDYPAKCHQCGNVFSNQKQLMVHRATVHENVNHKHSVVGFKDLTFVDFSSEKFPHIARYECEKNLHKGSGSMKFQCKKCSRAFPCSSSLEFHEKDCKESSSGLDLSSQKLSEVEVRRNDFFSRLNLQDISPEKHIPKKNEQDKTVKNEYRLLPDNNKDLADIQTIISMTTSGSLLQQLQHKTNEITNSLQVSNQEIKQESSKNEEEETQDAFAVEFRKMKLKGEFPCRLCTAIFPNLRALKGHNRAHLNGNNNGSYRCNMCPHSSIDKAALIRHMRTHNGDRPYECSLCNYAFTTKANCERHLRNRHAKTTREEVKKSIIYHPSEDPTNDEMTKLTAREDSRKSHNSSNEVFDYVPDKIHCSTPKFEVRPELKHITTPERKPLLSNLQSLKESLSLSVGKEPMQLFPNINDVIRNENLKSLKEYRNSHNGTIPVPPYLPPYGFQPKLNAVPSPGQIQVKDLSTLKMDPYENNSDEDDYEDDDDSIDVVLDLSKKKPTTEEPKPVDDAPQDLSVKSSPTYPQVPPPVAEMLQANLLKTPPKIDPAAFYAQWALLRNGFAGLPSWPSFPFNPLFLQQLQNQVPTGAAADMKDRLRNQLCGGTIIADNRLQALQQIRNAGLMPMGMNNFNSEPRQEVDTTYSPQNTQEDLSKPLSLKIEQSMNESMSKMASPLSHKPDIMQSPNSVKMVIKNGILMPKQKQRRYRTERPFTCEHCSARFTLRSNMERHIKQQHPQFWSQRQRGNIGNPGRKSQVMQMKPGFCDLSIPNYEIQKNQVYEDNKEMLSDRLKFAILAQHLRGVNNYNHAIKREEEEEDNLVIDENCEEKPTDLEIAESFEQEDQEEDEREESPKEQASFETKSGKLEESQDLVPVSRLLDNASQQQFNEYFKRDVEDNGAGSEEDEEGLVASGSTSEGNISGTDENKSESENTAPVKKKSAYSLAPNRVSCPYCSRKFPWTSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNAATTITNDVVNNNSNYLMRNVPERPFKCSSCPSSTFSTYTNLKKHISSKHATNAQGDDIRAQGYEAGSSEDEKIVHVSDNINEWNNQNLQTKVPNHEPLPSVVNADQPFKCHLCEYSFGERQEALDHIRDKHASEYDLLMSKNALDSSATTPEESAHNDEEDSEIRGKFPDYSNRKVICAFCMRRFWSAEDLRRHMRTHTGERPFMCDICRRRFTLKHSMLRHRKKHNVNYDNDAAMNSDDDGVSPKYEAGNNNKRAEDSDCNEGGDLISNLLGIRPSFIDKVLTASADDAAKLLGVKNGVKE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00130772;
90% Identity
-
80% Identity
-