Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 2.5e-27 2e-24 88.3 1.0 4 109 47 150 44 151 0.94

2 4 2.7 2.2e+03 1.2 0.0 80 106 153 179 148 180 0.84

3 4 0.026 21 7.7 0.0 80 109 172 201 159 202 0.85

4 4 7.6 6.1e+03 -0.2 0.0 80 108 204 232 199 234 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	2.5e-27	2e-24	88.3	1.0	4	109	47	150	44	151	0.94
2	4	2.7	2.2e+03	1.2	0.0	80	106	153	179	148	180	0.84
3	4	0.026	21	7.7	0.0	80	109	172	201	159	202	0.85
4	4	7.6	6.1e+03	-0.2	0.0	80	108	204	232	199	234	0.82

Coding Sequence: ATGCCAGCATTGGGTTCAACACATCAGTTGAAAGAATCTTACTTACTATGTACTAGAATTTGTCGCAAAGATgttccatttattttatttaaaaaatcgccaACACTTCTACCGAGTCACATAACCGATTGTTCTTTACTTTTCGAAAACAATGCGCTTACAAATTTCCAAATCATTGTTGGAGACAGAGAATTTCGAGTGCATAAAGATATTCTCGCTGCAAAGTCGCCAGTATTTCTAGCTATGTTTGACAGCgaaatgaaagaaatgaaagaaaatcagATGATTGTTGAGGATGTAGATGCAAATGTATTCCATGAAATGTTGCGATATATTTACACAAATACTGTAAAGGAGTTAGAAACTCATGCCGAGAATCTTTTGAAAGCAGCAGATAAGTACGATATACCGAAACTTAGATTACTTTGTGACGAGGAATTGTCTAGATCTTTAAAGATAGAAAACGCCATACATTTACTTGATCTTGCTGACACATTCCATGAAAGCACCCTGAAAGAAAGAACTTTGAAGTTCATACGAGcggCAGATAAGTACGATATACCGAAACTTAAATTACTTTGTGGCGAGGAATTGTCGAGATCTTTGAAGATAGAAAACGCCATACATTTACTTGAACTTGCTGATCAATGCCGTGAAAGCACCCTTAAGGAGAAAACGTTGAAGTTCATAGAAAGTAAcgtagaaaaaattttgcaaaccgAAAATTACAAAATGTGGTGTCAGACAGCGCCAGGATATCTCATGGCTGAGATATTAGAAACTATTGTTAATTTCAGCAAAGCCTATCCTCCCAGTAAGAGAAGAAGAATAGACGAAAATTAA
Protein Sequence: MPALGSTHQLKESYLLCTRICRKDVPFILFKKSPTLLPSHITDCSLLFENNALTNFQIIVGDREFRVHKDILAAKSPVFLAMFDSEMKEMKENQMIVEDVDANVFHEMLRYIYTNTVKELETHAENLLKAADKYDIPKLRLLCDEELSRSLKIENAIHLLDLADTFHESTLKERTLKFIRAADKYDIPKLKLLCGEELSRSLKIENAIHLLELADQCRESTLKEKTLKFIESNVEKILQTENYKMWCQTAPGYLMAEILETIVNFSKAYPPSKRRRIDEN

Sequence clustering based on sequence similarity using MMseqs2