Basic Information

Gene Symbol
RHOBTB1
Assembly
GCA_030710515.1
Location
JALBCR010000026.1:875792-878450[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2.8e-09 3e-06 29.7 0.0 7 48 223 263 217 282 0.79
2 3 1.3e-06 0.0013 21.2 0.0 39 99 317 375 312 383 0.82
3 3 4.9e-18 5.2e-15 57.9 0.0 5 108 410 512 407 514 0.93

Sequence Information

Coding Sequence
ATGGACAATGAACAGCCCCATCAGGAATTGGTGAAATGTGTCGTTGTGGGTGATACGGCTGTTGGTAAAACCCGATTGATTTGCGCCAGAGCCTGCAACCAGCAGGTGTCTTTGGCCCAACTGTTGGCAACGCATGTGCCTACCGTATGGGCCATCGACCAGTATCGAATCTACAAGGATGTTTTGGAAAGATCGTGGAGCGTTAACAATCCGATATCGTTGAGGAATTGTCGTTTGATGTGGTATCCCGAGATTCGTCGTTTCTGTCCAAATACTCCAGTACTATTAGTAGGATGTAAAAACGATTTACGTTTTATGTATCGTGATGAAGCGTATCTTACTTTCTTTAGAGATAGAAGTTCTTTTGTACGAGCTACTCGCAAATGTGATTTGGTGATGCCCGACGAGGCGCGAGATGTTGCTCAAGAGTTGGGCTTATACTACTACGAAACGTCCGTCTTGACTTATTTTGGAGTTAACGAAGTGTTCGAGAATGCTATTAGGGCAGCATTACAAGCACGTAGACAACAACGTTTTTGGCAGACCAATTTGAAAAAGGTACAAAGACCGCTTCTACAAGCGCCTTTTAAGCCGCCTCCGCCCCCAAAACCAGAAGTTAGTGTTTGTAATAGTTCATATACAGAAGATTTACATCAACTATGGATTGGCAAAGATCATTCCGATGTTGTTTTAGTATCCGGATCTATAGGCTTTTCTGCCCATCGTTATGTGTTATCCGCAGCTAGTCCCGCATTTTATAGGTTGTTTACGTTAGAGATAAATGCAGATATGACACGTAGTACTAGTGATTCAAGCATGGTTAGTTCCTTGGGCGACTTTAGCGACGATAACGAAAGTTTATTGAGAACAGAACAACGAACTTGGCGACGACGTGCAAGTTGTCAAGCTTTACCACCACCGCGCGAACTCGATCACCCCGCTTTCCAATCTATACGCACGATTCAATCGGAGGGACAGACTGTAGTTACTTTAGGTAAATTAATCAGTCCCGCTGCAATACGACAATGTTTGCAATTTATATACACCGGAACCATCGATCAACGCCAATTAGATCTTCAGGAAACGCGCCAGGCGGCGGAATTTCTCGAATTACCACAGCTTCTGGTGTTACTAATTGATATACAACAGTGTGGTAACGTAAGTGACGGAACTCGTTTGCAGGAAACTCACGAAGCTCACCTCAGAAGAAAGCTCCAGGATTTATGTTTGGATCAGGGGTTATTCGCTGACATAGTTTTTGAGTTAGATGATGGAGCGAGTCCGGCACATAAAGCCATGTTATCTGCACGGTGCGAAGTGATGAAAGCGATGTTCGGGGGCGATTTTCGCGAGAGCCAAGCTAAAGTTATCGAATTTCCTGGCGTCCGAGAGTATACATTCCATAAGTTATTATGTTATTTGTACACTGATGACATTCCTGCGGTGTCAGCTTCGCGCTGCGTTAATTTATTGGAATTAGGAAATCGGTTGTGCCTACCCCGTCTTGTTAATTTGGTGGAAAAACGTGTAATCGAAGATCTCGAAAGGCTACAAATGTCTGAAACTATAGAGCAGTGTCTGCGTTTACTAGAGCCTGTTAAGttgCATAACGCTCATCAGCTCGCCGATTGGTGTATGAACCATTTGTGTGTTAACTACAATAAATTGTGTCGTATGTCTCCTCGTAGTCTGCGCCTTTTACATCCGGACAACCAGGCTTATTTAGTGGAACATCGTTGGCCTCCCGCTTGGTATTTGAAAGATTACGATTATTATCAGAAATGTTTGGTAGAGCGTGATCGTGAAAATAAGCATGCGCTTAAATCTAGTTCGGGTTGTTTATGCTTTTCACGCAAGTCTGAATCTGATCCAGCCCTCGCTGGTCATCTTTAA
Protein Sequence
MDNEQPHQELVKCVVVGDTAVGKTRLICARACNQQVSLAQLLATHVPTVWAIDQYRIYKDVLERSWSVNNPISLRNCRLMWYPEIRRFCPNTPVLLVGCKNDLRFMYRDEAYLTFFRDRSSFVRATRKCDLVMPDEARDVAQELGLYYYETSVLTYFGVNEVFENAIRAALQARRQQRFWQTNLKKVQRPLLQAPFKPPPPPKPEVSVCNSSYTEDLHQLWIGKDHSDVVLVSGSIGFSAHRYVLSAASPAFYRLFTLEINADMTRSTSDSSMVSSLGDFSDDNESLLRTEQRTWRRRASCQALPPPRELDHPAFQSIRTIQSEGQTVVTLGKLISPAAIRQCLQFIYTGTIDQRQLDLQETRQAAEFLELPQLLVLLIDIQQCGNVSDGTRLQETHEAHLRRKLQDLCLDQGLFADIVFELDDGASPAHKAMLSARCEVMKAMFGGDFRESQAKVIEFPGVREYTFHKLLCYLYTDDIPAVSASRCVNLLELGNRLCLPRLVNLVEKRVIEDLERLQMSETIEQCLRLLEPVKLHNAHQLADWCMNHLCVNYNKLCRMSPRSLRLLHPDNQAYLVEHRWPPAWYLKDYDYYQKCLVERDRENKHALKSSSGCLCFSRKSESDPALAGHL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01345782;
80% Identity
-