Atri010371.1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Abrostola triplasia
Gene Symbol
MBD-R2_1
Assembly
GCA_946251925.1
Location
CAMIUJ010000039.1:2188573-2198314[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.1e-16 4.5e-13 48.7 0.0 5 59 724 787 720 841 0.76

Sequence Information

Coding Sequence
ATGGCTGTAAAAAAATGTTGTATTGACAACTGTAAGTCATGTTCCATAAGAAAACAGGACTATGGTGTAACCTACCATAAGTTCCCAAAAAATGTTGCACTAAATGACAGGTGGATATCCGTAACACATATCAAACACACAGTCACAGACCCGCCGCAGTATGTCTGCTCACGGCATTTCTGTAAACATGATTTCCAAATTTACAAGGACTCTAAATACATATTGAAACCAGACGCTGTACCTTCAATATTTCCATGGGAGCCTGACACTGAATCTGAAGACGAAATGGATAATATGACAGTAGAAGGTAACAGCAGGGACTGTGATGGTGAGAATGTGGATGCAATCAAGAAATTTATTGAAGCACAAGAGAAAGAGATTCAGGACAAGAGATTAATAGATTTTCAGCTTAGTGAGAAAAGTTGTGATGGTACAGATATTAATAGGCAAAGTCGTGAAGAGACCTTATCAATCACAACTAGTGTGATTGATATGATTATTTGCGATTCTGAATTGGAAATTGCTAAAAAGAAAGATGGAAAAAGTAAGGCTATTTTAAGCCCTGCTGACAAAGGCAGTAGCAGCATGGCACTATCTGTCGGTTCCAAGGTGGAAGCTAAGGATTTTGGAGAAGAATGGCATCCAGCAGAGATAATAGAAGTTGACTATGATGATATGGAGGTGCTTGTGCATTATGAAATTGACAAAAGGAAGCACGACGAATGGATAAGCGTGAGTAGTCCGCGTCTGAGGCCTGCTTCTATTAGCTACGCGACTGCTAGTAGCACCGTTACCGTCAAACCGGGACCTAGCTCTGAGGAGAGTCTTACCGATTGTATACCTATAGCTAATTTGAAGGAAGACTCGAAGGACCAGAAAGAGGATAAAGCAAAGCTAGAGTTCGCGGTCGGTGAACGATGCCTCGCTAGGTGGCGCGATAATAGACGGTTTATCGCTACCATACTCAAGGACTTGGGAGACGGCAATTTTGAGGTCTTATTCGATGACGGCTGTCATTGGACATGTAACACGTCAAGGCTTTACAAGCTGCGGACGAAGAAGGGCGCTGCGACCGCCTCGCCCGCCTCCCCCGGTCCTTTTGGCGCAGGCCCTAGCAACGCACAACCTAACACACAGCCACCAGTGTTTCACACACACCTGTTTGACCCCACACGCGACTACTTAGGCTCCAAAAAAGAACGCCGCGATATGAAACGGAAGCTAAACATTAAAGAAATATTTAATATAGGACAAAAACGACCAAAGAAACAGAAAAATCCAGAGGAAAAGACCCTTAAGGTTGTAGAAAGGAAACCCAGGGTGATGAAAAAGAGGATCAAGTTGAAGCTGGCGAGTGAAGAGAAGATTGAGCCTAAGGCTGAGTTACCTGCAGTAGACGCCGTAGCTTCAATCATCGGTACAGTAAGCCAAGAAGAGCCCATTGAGGAAGAAGTTAAAACTATTGAGAAACAAGAAGAGGTTGTAGAGAAGATCGAAGTAGAGGTAAAACAGGACATAAAAATTGATGTGGAAGAAATCGAGCAAACTGAAATTATTAAAAATGAAGACCTTATACAACTAGAAGATCTTAAAGGTGAATTGGACCCGGTCCTAGAAGAAGAGGTGATATTGGAACAATTTGAGAAACCTGACGATATCAAACACGAAGAAGTGATTGACAGAATCAAAGAAGTTATCAACAAGTTAGAGGACGGCATAAATCAGGCCATAAAAATGAGTTCACCTAAACCAGAGCCGAAGGATGAAGTAGGTACCTCCCCAGAAGTGAAGCCCCCAGATACGGCCAACGAAGAAGGGAAGCCAAGTGAAACACCTACAGAAAGAGTTAAACCGAAGAAGTTGTCAAAGGTGAAGAAAGGTAAAAAGCTGCGGTTGCTGCGCGCGAAGAAGGTTAAGAAGCAAGTGGAGAAGGTGAAGGGCGAGTTGGAGGAGATGAGGAAGCAAATGAACGAGATGAGGAAGCAGATGTTGACGAACCAGCGGAGCTTGAGCAAGGAGCCCATCACCGAGCTGCCGGAGAGCTTCCTGCTGCCCGGGGAGTGGTGCTGCCGCTGGCTCAACGGGCAGCCCGCCGGCAGCGTCAGCGAGCTGCCGGCCGAGCCGCGCCCCGACCCCAACGGCAAGTCGCCGCTGCCGCGCAGGAGCGTGCAGGTTGAAGATAAACGTTTGCCGGAGGGCTGGACGAAACATATGGTGCGCAGGAGCTTTGGCCACTCTGCTGGCAAGTGGGATGTAGTGTTGATAAGCCCCGACAACCGAAGGTTCCACACCAAGAATGAAATGCGGGTGTACCTGGAGAACAATCCTGAGTTAAACCTGCGCGAGTACAGCCACGCGCTGACGGACTTCGGCGTCCACCTGAAGCTGGCGCGCCGCATGGGCTGGATCTCCGTCACTCCCGACGGGCCCGCGCAGCCGCTGCCCGCCGGCACGCTCAGCAGCACCTCGCCGCTCATCAAACGCAAGAAGCTCAGCCTCCGGAAGGAGACTAAAGTGAAGCAGAGGAGGCCTAAGGCTCCTGTTAAGACTCCGCCGCAGGCTGGAGAAGGCTCTTCAGAGGTAACGGCAGATCCTTCCCCCAGCACTACAAGCTTGGATGAAGGTGCTGCAGCTATTGACGTCAGCCTTGACAACCCGCCGTTGGAGGATGGATATGTATTCGTGGGTTCGCTAAAAGTGCAGATAATCGACAACCTTCTTCGATGTCCGGCCGACAATTGCTTCAAGAACTTCAGGAACAACACGCTTTTGCAAATGCACATCAAACACTATCACAGAGAATTAAGAAAGATGATGGGAGCGACCCCCAAGGTTCAAGATCTAGCGTACGCCAGGACTATGCCAGTGGAAGTCGAGACACCGCGCGTCAAGGACGAGTCAAAGATCATCAAAGTCAAGATACCGAGACCACCCAAACGAGAGGAACCCAAACCGGAGGTTAAAGAAGTCAATAACGAACTGCAAGTGGACACAGTACATACGTCACCCGTCAAGGAAGCAGACCACATTCCAATACCTAAGAGTCAGGACTCGCCTAAACTGCGCCAAGCACTGATCAATAAGCCTGTGAAGAGACCCAAAGTGCTGCTGCCCGTGAGGCGACCCGAGCCAGAGCCAGAGCCAGTTATACCGGAGCCCATGCTCGAGGATATAGAGGTGGACTATGACGACAAATTGCCTATGGAACCCATTCTAGACATCCCGTGTATGGAGTCTCCGTTGGACTTCGAGAATGCGATATCGACGCACACTGTGACCAAGCCGAACGACAAGCGGCGGAAGGGAGAGAAGAAGCGGAAGTCCTTCAGTTTCGCGCTGAAGACGCCGCTTAGTGAGGAGGAGTGGTGTGGAGACGTGTCCGACATGGACACCAGGTCCAGCTTCCCGCGCTCCGCCACGCCCGACTCCAAGCTCGACGTGAAGCCGCTGGCAGCTCCCGAGGCCGTGGAAGACGTCAAGCCACCCAGTAACCAGTATATGTATACTGAAAACGGCGAGCGCATAAAGTTGGTGCGCATGAAGCGCGAAGAGATCATCAACTGCCACTGCGGGTACCGCGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGCCTGTGCTGGCAGCACGCGCTGTGCCACAACATACAGCGCGAGTGCGACGTGCCCGAAAAGTACACTTGCAGCATTTGTCTGAACCCCCGGCGAGGGCGCCGCTCGCAGCGCTTCCTGCACGACCAGGACCGCATGTACGAGGGGCTGCTGCCGGCCGGCAAGCCCTGCGAGTCGCTGCGGCGCGCGCACGAGCTGGCCGGCAACCTGCTGCGCGTGCAGGACGCGCTGCAGGCGCTGCGGGTCAAGTACTACGTGGCCACGAAAAAAGACCATCCAAAGTTGTACCTGTGGGCCAAGGATTGGGAGAAGGCTGAGATCCAGTACACCCAGGAAAAACTGAACTCTGACTACTCGGATCTGAACATAGTCATCAACACTGACAAGGAGAACCTCCCCATCCAGCCCGACGTCACGCCCTCCGATGACCATGAAAGGTACATGCACCGTGACGGGCCGCTGGGCTCGCAGCCCATGCTGAGCGGGATGATGTCGAGCCCGGGGACGGAGGCTTTCGACCTGCCCATCAGCACCTCGGAGCTGGAGCGCCTCGCCAAGTCTGTTCAAGAACAAGAGGTCCAGCGCACGACGATCACGGCCCCGGAGCCCGAGGCGGCCATAGAGAACAGCGCGTGTCGCGAGCGCCTGCTGAAGCACGTGCAGCGCTGCCAGGCGCTCGTCGACGCCAGGCTCGACTCCATCGATGCGCAGGTCGCAGAACTGGAATCCCAAAACCCATCGCTCGAGGACGACGAGACGGCGGAGTTCTTCCCGCGCACGAAGCAGACCATACAGATGTTAATGCGAGACCTGGACACCATGGAAGAGCTCGGGATCATAACTTAA
Protein Sequence
MAVKKCCIDNCKSCSIRKQDYGVTYHKFPKNVALNDRWISVTHIKHTVTDPPQYVCSRHFCKHDFQIYKDSKYILKPDAVPSIFPWEPDTESEDEMDNMTVEGNSRDCDGENVDAIKKFIEAQEKEIQDKRLIDFQLSEKSCDGTDINRQSREETLSITTSVIDMIICDSELEIAKKKDGKSKAILSPADKGSSSMALSVGSKVEAKDFGEEWHPAEIIEVDYDDMEVLVHYEIDKRKHDEWISVSSPRLRPASISYATASSTVTVKPGPSSEESLTDCIPIANLKEDSKDQKEDKAKLEFAVGERCLARWRDNRRFIATILKDLGDGNFEVLFDDGCHWTCNTSRLYKLRTKKGAATASPASPGPFGAGPSNAQPNTQPPVFHTHLFDPTRDYLGSKKERRDMKRKLNIKEIFNIGQKRPKKQKNPEEKTLKVVERKPRVMKKRIKLKLASEEKIEPKAELPAVDAVASIIGTVSQEEPIEEEVKTIEKQEEVVEKIEVEVKQDIKIDVEEIEQTEIIKNEDLIQLEDLKGELDPVLEEEVILEQFEKPDDIKHEEVIDRIKEVINKLEDGINQAIKMSSPKPEPKDEVGTSPEVKPPDTANEEGKPSETPTERVKPKKLSKVKKGKKLRLLRAKKVKKQVEKVKGELEEMRKQMNEMRKQMLTNQRSLSKEPITELPESFLLPGEWCCRWLNGQPAGSVSELPAEPRPDPNGKSPLPRRSVQVEDKRLPEGWTKHMVRRSFGHSAGKWDVVLISPDNRRFHTKNEMRVYLENNPELNLREYSHALTDFGVHLKLARRMGWISVTPDGPAQPLPAGTLSSTSPLIKRKKLSLRKETKVKQRRPKAPVKTPPQAGEGSSEVTADPSPSTTSLDEGAAAIDVSLDNPPLEDGYVFVGSLKVQIIDNLLRCPADNCFKNFRNNTLLQMHIKHYHRELRKMMGATPKVQDLAYARTMPVEVETPRVKDESKIIKVKIPRPPKREEPKPEVKEVNNELQVDTVHTSPVKEADHIPIPKSQDSPKLRQALINKPVKRPKVLLPVRRPEPEPEPVIPEPMLEDIEVDYDDKLPMEPILDIPCMESPLDFENAISTHTVTKPNDKRRKGEKKRKSFSFALKTPLSEEEWCGDVSDMDTRSSFPRSATPDSKLDVKPLAAPEAVEDVKPPSNQYMYTENGERIKLVRMKREEIINCHCGYREEDGLMVQCELCLCWQHALCHNIQRECDVPEKYTCSICLNPRRGRRSQRFLHDQDRMYEGLLPAGKPCESLRRAHELAGNLLRVQDALQALRVKYYVATKKDHPKLYLWAKDWEKAEIQYTQEKLNSDYSDLNIVINTDKENLPIQPDVTPSDDHERYMHRDGPLGSQPMLSGMMSSPGTEAFDLPISTSELERLAKSVQEQEVQRTTITAPEPEAAIENSACRERLLKHVQRCQALVDARLDSIDAQVAELESQNPSLEDDETAEFFPRTKQTIQMLMRDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00001248; iTF_00000413; iTF_00000357;
90% Identity
iTF_00001248;
80% Identity
iTF_00001248;