CBF
- Domain
- CBF_beta domain
- Group
- Beta-Scaffold Factors
- PFAM
- PF02312
- Desciption
- Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold [1].
- Rederence
-
- Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta. Goger M, Gupta V, Kim WY, Shigesada K, Ito Y, Werner MH. Nat. Struct. Biol. 6, 620-3, (1999).
