PC4
- Domain
- PC4 domain
- Group
- Unclassified Structure
- PFAM
- PF02229
- Desciption
- This domain is found at the C-terminal end of Activated RNA polymerase II transcriptional coactivator p15 from humans, YdbC from Lactococcus lactis, and other PC4 family members. p15 has a bipartite structure composed of an N-terminal regulatory domain and a carboxy-terminal cryptic DNA-binding domain [1-4]. Activity is controlled by protein kinases that target the regulatory domain.
- Rederence
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- Insights on the disruption of the complex between human positive coactivator 4 and p53 by small molecules. Pandey B, Dev A, Chakravorty D, Bhandare VV, Polley S, Roy S, Basu G. Biochem Biophys Res Commun 578, 15-20, (2021).
- A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M. Cell 78, 525-34, (1994).
- C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site. Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P. Nat. Struct. Biol. 4, 900-3, (1997).
- Structures of apo- and ssDNA-bound YdbC from Lactococcus lactis uncover the function of protein domain family DUF2128 and expand the single-stranded DNA-binding domain proteome. Rossi P, Barbieri CM, Aramini JM, Bini E, Lee HW, Janjua H, Xiao R, Acton TB, Montelione GT. Nucleic Acids Res. (2013).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000368 | Abrostola tripartita | Atri021389.1 | Ssb-c31a |