STAT
- Domain
- STAT_bind domain
- Group
- Beta-Scaffold Factors
- PFAM
- PF02864
- Desciption
- STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain Pfam:PF00017.
- Rederence
-
- Three-dimensional structure of the Stat3beta homodimer bound to DNA. Becker S, Groner B, Muller CW. Nature 394, 145-51, (1998).
- Structure of the amino-terminal protein interaction domain of STAT-4. Vinkemeier U, Moarefi I, Darnell JE Jr, Kuriyan J. Science 279, 1048-52, (1998).
