CSL
- Domain
- BTD domain
- Group
- Beta-Scaffold Factors
- PFAM
- PF09270
- Desciption
- Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR) [1].
- Rederence
-
- Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. Kovall RA, Hendrickson WA. EMBO J. 23, 3441-51, (2004).
