Basic Information

Gene Symbol
-
Assembly
GCA_907165275.1
Location
OU015670.1:6058929-6067082[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.073 5.4 8.2 0.8 1 23 386 408 386 408 0.97
2 11 0.0014 0.1 13.6 3.0 1 23 415 437 415 438 0.95
3 11 0.12 8.7 7.6 1.5 1 23 442 464 442 464 0.97
4 11 0.0033 0.25 12.4 1.3 1 23 469 492 469 492 0.98
5 11 0.12 8.7 7.6 0.2 1 23 496 519 496 519 0.89
6 11 0.027 2 9.6 0.0 3 20 533 550 532 552 0.94
7 11 0.68 50 5.2 0.5 3 23 616 637 614 637 0.96
8 11 0.011 0.8 10.8 0.6 2 20 653 671 652 674 0.92
9 11 9.7e-05 0.0072 17.3 0.5 1 23 680 702 680 702 0.98
10 11 2.2e-05 0.0016 19.3 4.2 1 23 709 731 709 731 0.98
11 11 0.00047 0.035 15.1 1.8 1 23 737 760 737 760 0.93

Sequence Information

Coding Sequence
ATGAAATGCATAGTACCCGGCTGTAGAAATGATTCCAGAAGTGTTTTCAAATCGGAAGGAATTTCATTCCATGCTTTCCCAGCAGAACCGTCAAACCGCACAGCATGGCTGAAAGCTATTGGAATTGAGCCATGTGTGCCTCAGCAGAAAGGCAGTGCAGTGTGTTCCAAGCACTTTTTGGATGAAGATGTGTATTTCACCAAGCATATGAAGAGAAGGGTGCATATGGGAGCTGTGCCTGTGGTCTCCCAAGATTCTACAACATGTGACAGCGAAAAACCGGAAATTTTAAGGATCTGCAGGATATGTCTGCTGATGGATACCAAACTTCATTCCATGAAGAGTTGCAATTTGGAGACAGCCTACTCGCAACTCACTGGACTGCCGCTGGAGGACGGCTTGCCGCAGGAGGTGTGCTGGGAGTGCGCCCAGCGCGTGCGCAACTGCGCCAGGCTGCGCGCGAGGGCGGTGAAGGCGCACGCGCTCATGAGCAGCCTGCTCGAGCGGGAGGGGCGCCTTTCTCTGGAATTAATGAGACATATAAACAGAGAGAGTAACCAATTGACAAGTAATCTTAGTATAAATCATTATGATAATGATCACACAGACTTGTATGTATACAAAACAGATGAAACACAAATAGACACAAGTGATAAAATGCCACAAACACCGCAGGATATAGCAGAAGTTAAAGTCGAAATGGATAATGATATATTTTTGGAAGAGAATGACAATTTCCATCAGGAAGATGACGACATTGATCATGAAGTGAACACAGCTGAGAATACAGCTGTGAAAATTGATAACAGTAATATTGGCAAAACAATCAAAGGGGATGCTTGTGATGAATTTGAAAAGGAAATAGACAAGTTTCTAGCCGCATCGGAAAATGATTTTTCATCGGACGACAGTTTACCTTTGAAAGTGACTAAAAGTGTGAAGAAAGTTAAAAAAAAAACAAAAGAAAAAGCCGAGAGAAAAGTCAGGAAGAAATTAATAAAAAAACCTGGAGAGCCGAAGATCGACAGGCGAAGAAAACCGTTTTTGAATGCAGACCTGAATGAAACACTATTCACAATCAAAATTTTGACCATTGAAGAGCAACTAGCTGAGATGCTCAAGCGGAGAGAGTCTGCTAATTACAAAAACTCTGTGTACAAATGTACGGAGTGCTACAAAGGATTCTTAGAGGACGAAGCTTATAGGAGTCACATGCTCAAACACAGTACCAAATGTGGCGAATATGTATGTGATATATGTAAATCTCACTTCCCACATCCAAACGCGTTGAGGAAACATATTACAGCGCATCACACACAGAAGTACACTTGCAATGAGTGTCCGTTCATCACAACCCATCGACAAACGGCGCGGCTGCACGAGCGCTGGCATAAGGGCACGAGCTACAAGTGTCCGCATTGTGCTGAAGTGTTTATCAAGTTCACAACTTATATGGGCCACATTCGCATCAAGCACCCGTCGGACTTCGTTTGCGGGCTCTGCGGGTTCTCCTTCATCAGCGCGAAGGGCATCGACTTGCACAAGAAACTCAAGCACCGACTCGACGATATGCAGGTGCCGGCGGACGGGCCGCACTGCGCCGAGTGCGACGTGCGCTTCGCGTCGGCGCAGGCGCTGCGCAACCACCTCGGCGTGTCCGCGCGGCACGCCACCGCCAAGGACGACAAACCGCGTGAACCGAACAAAATGCGACCCCGCAAGGTGCGGCAGCCGGGGGCTGCGCGGGGGAGGGCCGAGAAGAAGACGGACGGGGAGGGGGAGGGAGAGGTCGCAGAGAGGAGGCTGTTCCCCAGCCAGATGAGGAAGGCGGAGGGGCCCATAGACTGCGAACAGTGCGGCGTCCAATTGGAGGATTCGCGGGCGTACCACAGCCACTTCCGGCGCGTGCACCCCGACAAGAACCGAACCAACTACCCCTCGATGAAGTCACCGTGCATGTGCGAGGTCTGCGGCAAGATATTCCAGAGCTACGCGCTGCTCCGCGACCACACGTGGCTGCACACCGGCGAGCGGCCGTTCAAGTGCGACGCGTGCGGCAAGGCGTTCCGCATGAAGCAGCGGCTCGTGGCGCACCGCCGCGTGCACAGCCAGACCAAGCCCACCTACGTGTGCGCCGTGTGCGGCAAGCACTTCAGCACGCACAGCAACCGCCAGCGGCACATGTTCATCCACACCGGTCTTAGGCCTTTCAAGTGCGAGATGTGTGGCAAAGGCTTCAAGCACTTCAGCGAGAAGCGCGCCCACGTCGAGTACGTGCACCTCAAGAAGCCGTGGCCGAAGCGCTCCCGGGGAAAGAGACGGCAGTCGGCGCAGGCGGCGGGCGCGAGCGAGACGGACGCACCCCCGCCGCCGTGGGCCGCGTGCGAGGCGAAAATGGGCGACGTAAACATGTTGGAAGACAAGCCAGTGTATTACAGTGATATGAAAATGTAG
Protein Sequence
MKCIVPGCRNDSRSVFKSEGISFHAFPAEPSNRTAWLKAIGIEPCVPQQKGSAVCSKHFLDEDVYFTKHMKRRVHMGAVPVVSQDSTTCDSEKPEILRICRICLLMDTKLHSMKSCNLETAYSQLTGLPLEDGLPQEVCWECAQRVRNCARLRARAVKAHALMSSLLEREGRLSLELMRHINRESNQLTSNLSINHYDNDHTDLYVYKTDETQIDTSDKMPQTPQDIAEVKVEMDNDIFLEENDNFHQEDDDIDHEVNTAENTAVKIDNSNIGKTIKGDACDEFEKEIDKFLAASENDFSSDDSLPLKVTKSVKKVKKKTKEKAERKVRKKLIKKPGEPKIDRRRKPFLNADLNETLFTIKILTIEEQLAEMLKRRESANYKNSVYKCTECYKGFLEDEAYRSHMLKHSTKCGEYVCDICKSHFPHPNALRKHITAHHTQKYTCNECPFITTHRQTARLHERWHKGTSYKCPHCAEVFIKFTTYMGHIRIKHPSDFVCGLCGFSFISAKGIDLHKKLKHRLDDMQVPADGPHCAECDVRFASAQALRNHLGVSARHATAKDDKPREPNKMRPRKVRQPGAARGRAEKKTDGEGEGEVAERRLFPSQMRKAEGPIDCEQCGVQLEDSRAYHSHFRRVHPDKNRTNYPSMKSPCMCEVCGKIFQSYALLRDHTWLHTGERPFKCDACGKAFRMKQRLVAHRRVHSQTKPTYVCAVCGKHFSTHSNRQRHMFIHTGLRPFKCEMCGKGFKHFSEKRAHVEYVHLKKPWPKRSRGKRRQSAQAAGASETDAPPPPWAACEAKMGDVNMLEDKPVYYSDMKM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01569410;
90% Identity
iTF_01569410;
80% Identity
iTF_01569410;