Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.054 3.2 9.5 5.1 1 23 97 120 97 120 0.95

2 6 0.00012 0.0075 17.8 3.5 1 23 129 152 129 152 0.97

3 6 0.00059 0.035 15.7 3.4 2 23 162 184 161 184 0.95

4 6 0.13 7.9 8.3 1.4 1 23 193 216 193 216 0.94

5 6 3.7e-06 0.00022 22.6 2.9 1 23 225 248 225 248 0.97

6 6 0.0049 0.29 12.8 0.2 2 23 258 280 257 280 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.054	3.2	9.5	5.1	1	23	97	120	97	120	0.95
2	6	0.00012	0.0075	17.8	3.5	1	23	129	152	129	152	0.97
3	6	0.00059	0.035	15.7	3.4	2	23	162	184	161	184	0.95
4	6	0.13	7.9	8.3	1.4	1	23	193	216	193	216	0.94
5	6	3.7e-06	0.00022	22.6	2.9	1	23	225	248	225	248	0.97
6	6	0.0049	0.29	12.8	0.2	2	23	258	280	257	280	0.92

Coding Sequence: ATGCCTTTCCAAAATGACCCTCTTATCAAACCGGAATACATCGTGGGATGTTTTAACTGTGCTAACGACCTCGAGCCCTTCTCGTGCACCACCTGTGGCAACTTCCAAACCAACTTCATATCGTACTTACGCCACCACAGCAAAAATCACACCCACGACCTTTCCGATCACCCCCTCAACAAGTGCAAAAAATGCACCTTCGAAACCCACTCGAAAATCGTGTTCCTTAAACACACTTGCAACCCCCGCAATTTTCGCCCGTACTCCCCGGACTACGAAAGCCAGTGGTTCCACTGCACCCAGTGCCCCTCGAAATTCAAGCTAAACCACCTTTTACGCAAACACGTCGCCTCCAAACACCAACCAGACGACGAAATTCAGTGGTTCCAATGCGAACAGTGCACGGCGAAGTTCAAACAGAACCACCTTTTGCGCAAACACGTCATAACTAAACACCTTCCCGAAGACAAAATCAAGTGGCTGCGCTGTGAGCAGTGCACGGCGAAGTTCAAGTTCAAGTCGCACTTGACGAGTCACGTGCGGGCGAAGCACGTCGCCGAGGACAAAATCCGGTGGTTTGAATGTGAAAAGTGCCCGTTTAGGTCGAAGGAGAGGAGGTTTTTGCAGTATCATATTTCGGAGACGCATTTGGCGGAGAATGAGATTGAGTGGTTTCAGTGTGAGCAGTGCAGTCAGAGGTTTAAGAGGAAGTATAATTTGAAGGTGCATGTGAAGGTTAAGCATGTGCCGGAGGATGAGATTGAGTGGGTGCAATGTGAGCAGTGTCCGGCCGTGTTTAAGCTGAAGAGGTATTTGAAGGAACATGTGGCGTTGAGACATTTGTTGAAAGGGAAGAGGTAG
Protein Sequence: MPFQNDPLIKPEYIVGCFNCANDLEPFSCTTCGNFQTNFISYLRHHSKNHTHDLSDHPLNKCKKCTFETHSKIVFLKHTCNPRNFRPYSPDYESQWFHCTQCPSKFKLNHLLRKHVASKHQPDDEIQWFQCEQCTAKFKQNHLLRKHVITKHLPEDKIKWLRCEQCTAKFKFKSHLTSHVRAKHVAEDKIRWFECEKCPFRSKERRFLQYHISETHLAENEIEWFQCEQCSQRFKRKYNLKVHVKVKHVPEDEIEWVQCEQCPAVFKLKRYLKEHVALRHLLKGKR

Sequence clustering based on sequence similarity using MMseqs2