Basic Information

Gene Symbol
Zfy2
Assembly
GCA_027724725.1
Location
JALNTZ010000002.1:19770063-19773215[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 27 5.6e-06 0.00033 22.1 3.5 1 23 91 113 91 113 0.97
2 27 0.0002 0.012 17.1 1.2 1 23 119 141 119 141 0.97
3 27 1.1e-05 0.00064 21.2 6.9 1 23 146 168 146 168 0.99
4 27 0.026 1.6 10.5 0.3 3 23 176 197 174 197 0.94
5 27 0.00083 0.05 15.2 0.2 2 23 203 224 202 224 0.97
6 27 0.00012 0.0074 17.8 1.0 1 23 234 256 234 256 0.97
7 27 8.5e-05 0.0051 18.4 0.2 1 23 262 284 262 284 0.98
8 27 9.1e-06 0.00054 21.4 0.5 1 23 290 312 290 312 0.98
9 27 1.6e-06 9.5e-05 23.8 4.1 1 23 318 340 318 340 0.98
10 27 7.9e-05 0.0047 18.4 2.3 3 23 366 386 364 386 0.95
11 27 5.4e-05 0.0033 19.0 0.7 1 23 392 414 392 414 0.98
12 27 0.0014 0.083 14.5 0.9 1 23 420 442 420 442 0.98
13 27 0.0086 0.51 12.0 0.1 2 23 449 471 448 471 0.92
14 27 0.00028 0.017 16.7 4.0 1 23 476 498 476 498 0.96
15 27 0.15 8.8 8.2 3.2 2 23 508 530 507 530 0.92
16 27 0.00034 0.02 16.5 1.2 1 23 537 559 537 559 0.98
17 27 6.9e-06 0.00041 21.8 0.7 2 23 566 587 565 587 0.97
18 27 4.4e-07 2.6e-05 25.5 1.3 1 23 593 615 593 615 0.98
19 27 0.47 28 6.6 0.1 1 13 621 633 621 635 0.89
20 27 0.81 49 5.8 3.8 1 19 687 705 687 705 0.97
21 27 7.1e-05 0.0043 18.6 2.3 1 23 716 738 716 738 0.97
22 27 0.069 4.2 9.2 0.1 1 23 744 767 744 767 0.87
23 27 0.83 50 5.8 0.2 2 23 780 802 779 802 0.94
24 27 0.0006 0.036 15.7 1.9 3 23 810 830 808 830 0.96
25 27 1.5e-06 8.8e-05 23.9 1.7 2 23 837 858 836 858 0.97
26 27 0.015 0.93 11.2 5.2 1 23 863 885 863 885 0.95
27 27 0.012 0.73 11.6 7.0 1 23 891 913 891 913 0.99

Sequence Information

Coding Sequence
ATGTCATCCCTTCAGTGTAAATACCTCATGAATTTAGTGGATTCTAAACAAATTCCGGAAGACAACATTCTCGAAAGTTCCGTGGTGGACCATTTGAACGAATCAGATGCCGATCTCTTAAACCTTCTAACGACCGGAGACGACTGTTCCGACATTCTTAACAACATTGCCACGAATGAACAGTTCGAGCGACTTATGAACAGCGATTCCAATTTCGTGGATGAAATAATCGACGAAATGAAAGAAGAAACGCAAAAAGTAGAAAACACGTTCAAGTGCTATCAGTGCGGGAAGGTTTTCAAAACAAAGAAACTGTTAAAGAAGCATCTTTTTATTCACACGGGTATTCGTAAGTTCTCGTGCGATGTCTGCGGGAAGAGTTTCAAATATAGATATGAAGTGGATGTCCACAAGAAGAGTCACAACAACCCGACTTTCCAGTGTGATATTTGTTCGAAGATGTTTATACACAAGTCGCATTTGACAACCCATCGACGCAAGCACCTGAATGAGTTCGTGGACTTCTGTCAGGAGTGCAATATGGGTTTTGTGACGAAATTTTTGTATACGAGTCATGTTAATCTTGTACACAAGAATTTGCAACTGGTGTGCGATACTTGTGGAGCAAGACTCAGCTCGTTGTCTTCTTTGAAAGAGCACCAGTTGACTCATGATCCCAACTATGGTAACGAAAGGCATCATGTGTGTGAAATCTGTGGAAAGTCTTATCTGAGTTCGCGAAATTTAAAGGGTCATATGAAGATACACAAACAAATTCGGAGTTACGTTTGCAACATCTGTGGAAAGTCAGTTAGCAGTAAAAAGATTTTGGAAACACATATCAAGATGCACACAGGACTTAAAGATTTTATTTGTAAGGTGTGCAATAAAGGGTTTGCTTCGAAAGAGTATTTGAATGTCCATACTAGGATACACACAGGCAATAAACCCTTTAGTTGTGAAACTTGTGGAAAGAGATTTACACAGAAGACTTCCTTGACGGTACACATGAGGCACCACACCGGTCAGAGACCTTACAAGTGCGAGAACTATGAAAAGCGACAATCCAAGAAAAGTGTAGGGAAAACAAAATGTTGCACCCTTTGTTCTAAGACGTTTCCAAACAATGCTAAACTGGAGCGTCACATGCTGGTGCATTCCGATCTTCGACCTTACTCGTGTGATCTTTGCCCAAAAACCTTCAAACAAAAATATGATATAGTGATCCACAAACGTGTCCATGATAACAACTCTTCATTTCCATGCGACTTTTGCGAAAAAATATTGAAAACTAAAGGCTCCTTGGTAACCCACAGGAAACGCCATTTGAAAGATTATGTCAAAGTGTGTAAAATTTGCGGCGCTGGGTTTGTCACCAACCAAGAGTACAACAACCATGTGGGTTCGAAACATGGTACTGGTGCCCATATTTGTCACATCTGTGGAAGAACTTGTTACGACAAAGCGGCTTTGCAGAGTCATATGGTCAAGCACGATGACGGATATAAAAATAACAAACTCAAATGCGAATTTTGTAGTAAAACTTTCCTACAACAGAAATACTTAAAGCAGCACTTCTTCCGGGTACATAAGGATGGGGGACACAAATTTATATGCGATTTGTGTGGAAAAAATGTACATTCGAAAACTAGCTTGCGGGATCATATGATAACGCATTCGGGTTTAAAACCAGTTGAATGTAAACAGTGTGGGAAAAAATTTGCTTTGAAAACTACACTGAGGGTACATATGAGGATCCACACTGGAGATCGTCCTTATGTTTGTAAAAATTGTGGAAAAGCGTTCACCCAGAAAACGGCTTTAACGACACACTTGAGGTACCACAGTGGAGAAAGACCCTACGTTTGTGATATATGTAGCAAAGGTTTCGTCAGTCGGGGCTTGTCTGTTAAACAATCTCTTAGTACGAACTCCAGTGGCAAGAAAATTAAAATTTCGTCTTGTACGGTGGTGAGCGTAGTTAAAATGAATAAAACTAGAGAACCCAACACATCGACAAAATTAACACCCGCTGGTACTACCGTCAAGAACGCACAATATTTTTGTTCCAAATGCAGAGAGACGTTCCATAGTTATCACGAATTAACAATCCATGACAAATCGTGTGTTAAACCTAGAGTCCCCCACGTTTGCAAATATTGCCGAAAGGACTTCAGTTCGGCCTACAGTCTAAAGCTCCACATTGCCCGTCACGAAACTGCCCCTCAGTACGCCTGCGCAAAGTGTGGCAAAGGCTTTAGTAACATCGAAGCTAAAGAATATCACGAGGACACCCTCCATACGGAATTTTTTGACGCTTGCGCAGAGGGTGGGGTTCAGTGCAAATTATGTGACGTCAAAGCGGTCAACAAAACAATGATGGACAAACACATCAAGGCCAATCACACGGTTGAGGCGCCATGTTTGTGTGACGTCTGCGGTAAAAGTTTTGACACTAGAAAAAAGTTGTTCTTGCACCAGGTGGTACACGAGACTGGAAAATCCTGGCAGTGCGAGTATTGCTCAAAGAGTTTTAAGCACAAGAATGCCCTCAACGCTCATATGAACATTCATGAAGTAAGGAGTTTTGAGTGTGACGAGTGTGGACGTACGTTTAAGAAGAAGTTCACCTTAAATTGTCACAAAAAGGAACACTTGGGACAGTACACGTTCCAGTGCCACGTTTGCGGCAAAAACTTTGTTTGTAAGAGTTCTGCGATCCATCACATGAAGAGACATACCGAATAG
Protein Sequence
MSSLQCKYLMNLVDSKQIPEDNILESSVVDHLNESDADLLNLLTTGDDCSDILNNIATNEQFERLMNSDSNFVDEIIDEMKEETQKVENTFKCYQCGKVFKTKKLLKKHLFIHTGIRKFSCDVCGKSFKYRYEVDVHKKSHNNPTFQCDICSKMFIHKSHLTTHRRKHLNEFVDFCQECNMGFVTKFLYTSHVNLVHKNLQLVCDTCGARLSSLSSLKEHQLTHDPNYGNERHHVCEICGKSYLSSRNLKGHMKIHKQIRSYVCNICGKSVSSKKILETHIKMHTGLKDFICKVCNKGFASKEYLNVHTRIHTGNKPFSCETCGKRFTQKTSLTVHMRHHTGQRPYKCENYEKRQSKKSVGKTKCCTLCSKTFPNNAKLERHMLVHSDLRPYSCDLCPKTFKQKYDIVIHKRVHDNNSSFPCDFCEKILKTKGSLVTHRKRHLKDYVKVCKICGAGFVTNQEYNNHVGSKHGTGAHICHICGRTCYDKAALQSHMVKHDDGYKNNKLKCEFCSKTFLQQKYLKQHFFRVHKDGGHKFICDLCGKNVHSKTSLRDHMITHSGLKPVECKQCGKKFALKTTLRVHMRIHTGDRPYVCKNCGKAFTQKTALTTHLRYHSGERPYVCDICSKGFVSRGLSVKQSLSTNSSGKKIKISSCTVVSVVKMNKTREPNTSTKLTPAGTTVKNAQYFCSKCRETFHSYHELTIHDKSCVKPRVPHVCKYCRKDFSSAYSLKLHIARHETAPQYACAKCGKGFSNIEAKEYHEDTLHTEFFDACAEGGVQCKLCDVKAVNKTMMDKHIKANHTVEAPCLCDVCGKSFDTRKKLFLHQVVHETGKSWQCEYCSKSFKHKNALNAHMNIHEVRSFECDECGRTFKKKFTLNCHKKEHLGQYTFQCHVCGKNFVCKSSAIHHMKRHTE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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