Basic Information

Gene Symbol
-
Assembly
GCA_000696155.1
Location
NW:693757-701210[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 9.5 3.4e+02 1.4 0.6 1 11 204 214 204 223 0.79
2 18 0.0011 0.038 13.8 2.6 1 23 231 254 231 254 0.96
3 18 0.0014 0.052 13.4 3.3 2 23 259 280 258 280 0.97
4 18 0.013 0.47 10.4 3.7 1 23 317 339 317 339 0.98
5 18 0.00015 0.0054 16.5 4.9 1 23 345 367 345 367 0.95
6 18 0.0027 0.095 12.6 1.5 1 23 454 476 454 476 0.98
7 18 0.00015 0.0054 16.5 0.6 1 22 559 580 559 583 0.90
8 18 0.089 3.2 7.8 0.3 1 23 743 765 743 765 0.97
9 18 0.00088 0.032 14.1 0.4 2 23 800 822 799 822 0.94
10 18 0.00044 0.016 15.1 1.5 1 23 829 851 829 851 0.97
11 18 0.081 2.9 7.9 0.3 1 21 857 877 857 880 0.86
12 18 0.33 12 6.0 2.1 3 23 885 905 884 905 0.96
13 18 3.7e-06 0.00013 21.6 1.3 1 23 912 934 912 934 0.98
14 18 0.0065 0.23 11.4 1.9 1 23 940 962 940 962 0.97
15 18 4.8e-05 0.0017 18.1 0.8 1 23 968 990 968 990 0.97
16 18 2.7e-06 9.9e-05 22.0 3.6 1 23 996 1018 996 1018 0.99
17 18 0.00016 0.0059 16.4 0.3 1 23 1024 1046 1024 1046 0.97
18 18 0.0052 0.19 11.7 2.9 1 23 1052 1075 1052 1075 0.95

Sequence Information

Coding Sequence
ATGAAGAAAGTAACATTGGAAAGTACAAAAAAGGCAAACTGGCCTCATCAAGGATTGcacagtaatatttattctgaaagtaTTATTCACCATTGTTTTATATGTGATGAGGAAATTATGGGCAGAGGGGTCCCTCTGTTAGTAAGCCATACATCCTATACGAAGACTGGGCTTCCAACAAAAATAGGACAACTAATGGGGGAAGGCTTCATGGTGGTTGTATCAGTAGGAGACATGCTGTGCAAACGCTGTGCTGCTTTGTTGAATCACCTTGATAAATTAGAATCTGATCTAGATATTGTAAAACGGGCCCTAACAGGCTACTTGAAGATGAAGTATGGCCTCCTAGACAATACCGATGAACAAGTGGAACctgataaacaaaatataacaagtGAAACAAATGTAGAAGaaatgccTAATATGACAACTGGTGGTGGGACCACTGAGGTTTCTGAGGACTCATATGCAAGTGAATCAGAACCTGAGTCTTCACATGGAGCAGTCAGTAGCAACAGAACCATTGAAATTCTTCTAGATGAAGGCCCTAGTGCTTCAAAAGATCACTCACAAATCCAAAAGAAAGACTCATCTCCATCTCTGAAGGTATACAAGTGTacaacttgtaattttaaaacatcagaacttgCTCTATTTCAACCTCACTTTTTGTCATGCAGTGAGCTGCCTTACAAATGCACTATGTGTGAGAAAAGGTTTGAGAGCCATAAATATGTTAGAACTCATATCATGGAAGCACATCTTTCAAATTGGACATGCCATTTTTGTAACACAGACTTCAGTGAAGAAAAGGAATTCACATCACACATGAAAACTCATTTATGTCACAAAAGTAGTTCCCCAAAAGTCCATGTAGAAGAATTATTGTATGCCAGTGGCAGCGAGGATGTAACATATAATTCTTCACAGAATGCGTTGCTGGCGAACtatgaatgtaatatttgtgattACCAATGCAGCAATAAGGAAGAGTTTGATGAACATGTACATAAGCATGTCATGTTGAAACCTTTTCAATGTAAAGTTTGTAAGAAGAGGTTCCAGCACCAAGAAGATTTAACACATCACATGGGTGACCACAAATCAGAACTCTTGTGCTCTGCAGAATTTGAGAAGAAACGTAGCCTGTTAAAACATGAACACAGTCTTATGACAGAGTTGAAGGGAGAGACATTTCACAACAAAGGAAATGACATAATAGAATTTTTGGATCAGACATTAGATGATACAATAAAACCAACCTCTGAGAAAGGGAAACTGGATAGTTTCATcagagaaactgaaaataaacacaatgcaGAGTCATCCAGTGAGTGCAGgaaaaatgaaattgaatttcATACATGCCAAGTATGTTCACTAACGTTTGTCAATGAATCGCTCTTTGTAGAACATACCAAGATGCATAAGCAAGAGGAAGCTAGTAAAGAACTATTCAaccaacattccagaaaacTCCTACAAATGGGAAAAGTCGATCTGGATGATGATGCAACAGAACATGATGTGAACTCCATCAATTCAGAAGGAAGGCAGCAGTATGTTGAAATGGACGAAAGCCTTGAGGATATGTTTGAAAAGCTTGATTCAGTGACAGAAGTTGCTCattcttctgaaaataaagaagCAACAAATCACACTACACTAGCAATATATAAATGCAACACATGTCCAGAGGAATTCAGGAACAATGATGAATTGCAGCTGCATAAAGTAACACAAACACATCTCACtaatgattctcagaatgaCAAAGTGGCCATGATGATAGAAGATAAAAGTGATGCTTCTATAGTTGATACATTTAACCAAtgtaaaactgaagaaaatgtaaccGATATGCAACAATGTGAAAGTATAGCAGACGATGGATTGTGTGCTGAAACTTTATTAATTGGGCATGCTGAAAGTCCGAAAGTCCTACCAATACAGAATGACCACTGCCAAATTCAAGAAAATGACAGTGAAAAGGATGGTTTTCTCGATATATTTGATATGGTGCGAGAAAAAAAACTTTCTGCAAATGTTAGTGGTGAAATAGATCCAGTTTTATTGCAAGATATGTGTGAGACGCAAGTGAAAGCAGAACAGATTGAAGTGACACCTGCAATAGAGTTTCTTCCACACATAGCACCAGACATGAAACATCTGAATGACAGTGAGGTGTATAAAACTGCACCCATTCCAACCCAGAGCAACAAGACTTATGTATGTGCGATGTGTGGTTATCGAACTCCCGCAATGTTTGATTTGAGGAGGCACTTCAAAGAACACAGACAGAAATCATTCAACTGTAAAATTCACAACAAAGTGTTGCCAAGCACCCAGAAATTGTCTAACCACTTAAAAAGTCATGACAGGTTTTATGGTAAAATGACATGTCCATATTGCTATGTACAATTCCCTGACAGGTATAGCCTTCAGCAACATTTACAGGAGAAGCATCAAAAGGAGAAGGTGATGTACAAGTGTTCATTTTGCAGCGAAACTTTCAACACAAAGAAAGCATACAAAGCACATGAGGAGATTCATCCAGAAAGATTTTCTTTCAGGTGTAATGAGTGCGGTACACCATTCCTGAAGGAGAAGCAGCTCCTTGATCACAAAGACGCGGTTCATAGAGATCCACATTGTCGTTTCTGTGGTAAAGAGATAGTGAAAGCAAAGACCCTTAGAAATCACGAACTTAGACACATCAGACAAAAAGATCATTTTGAGTGTGATATCTGTAAACGGGTGTTTAAAACAAAGACAGGTCTAAGGCACCACATTGCAGTGCACACTGGTGAGTACAAATATTGCTGTGATTATTGTGGCCGAGGCTTCATGTCCCGCATGATGATGGAAGAGCACCGCAGCATGCACACAAAGGAGGAACGCTATATCTGTGATGTTTGTGGTCGCAAGTTTAGTTTCCAGAGCACATACTGGATTCACCGTAAGTGGCATGATAATCCTTATCCATATAAGTGCAGCTTCTGTGGCAGGATGTTCCGACACTCATCATTGCTGGCAGTTCACAAGAGAACCCACACAGGTGAACGTCCATACAAATGTCCACACTGCCCATTAACATTTCCAGTGGGTGGAACACTCAAGCGACATCTTATCCTACACACTGGTGTATATCCATTCAACTGTGAGAACTGTAAACGTGGTTTCACCACCCGGCATAAATATGCAACTCACCTTGCAAAGATCCATGGAGATTTTGAGATGCTTCATGCTAAGCCCCAACAGAGCGAGTTCAAAATGGTCATCCGAGATGAACCTAAACCCATCCAACAGCCAACAGTGTGGGAAGTTACTGACGACTCTGTTCCAGACCAAATGAATTTCAAACTGGAGACAATTACAGGAGATGATGATAGAAGTAAAGACCCAGTTCATGAAGGAATTGCTTGCACTATAGTTTCAGATGAGATGCTGGTGGATAACATGGTTCCTACCAGAGTAGTGGAAATTGTTTTAGATGAAACTTCACAAGCTGTTGCAACAGTTACCCTTGCAGAACATGCAAATATCCTTCCTGATATCTGGTATCAGTAG
Protein Sequence
MKKVTLESTKKANWPHQGLHSNIYSESIIHHCFICDEEIMGRGVPLLVSHTSYTKTGLPTKIGQLMGEGFMVVVSVGDMLCKRCAALLNHLDKLESDLDIVKRALTGYLKMKYGLLDNTDEQVEPDKQNITSETNVEEMPNMTTGGGTTEVSEDSYASESEPESSHGAVSSNRTIEILLDEGPSASKDHSQIQKKDSSPSLKVYKCTTCNFKTSELALFQPHFLSCSELPYKCTMCEKRFESHKYVRTHIMEAHLSNWTCHFCNTDFSEEKEFTSHMKTHLCHKSSSPKVHVEELLYASGSEDVTYNSSQNALLANYECNICDYQCSNKEEFDEHVHKHVMLKPFQCKVCKKRFQHQEDLTHHMGDHKSELLCSAEFEKKRSLLKHEHSLMTELKGETFHNKGNDIIEFLDQTLDDTIKPTSEKGKLDSFIRETENKHNAESSSECRKNEIEFHTCQVCSLTFVNESLFVEHTKMHKQEEASKELFNQHSRKLLQMGKVDLDDDATEHDVNSINSEGRQQYVEMDESLEDMFEKLDSVTEVAHSSENKEATNHTTLAIYKCNTCPEEFRNNDELQLHKVTQTHLTNDSQNDKVAMMIEDKSDASIVDTFNQCKTEENVTDMQQCESIADDGLCAETLLIGHAESPKVLPIQNDHCQIQENDSEKDGFLDIFDMVREKKLSANVSGEIDPVLLQDMCETQVKAEQIEVTPAIEFLPHIAPDMKHLNDSEVYKTAPIPTQSNKTYVCAMCGYRTPAMFDLRRHFKEHRQKSFNCKIHNKVLPSTQKLSNHLKSHDRFYGKMTCPYCYVQFPDRYSLQQHLQEKHQKEKVMYKCSFCSETFNTKKAYKAHEEIHPERFSFRCNECGTPFLKEKQLLDHKDAVHRDPHCRFCGKEIVKAKTLRNHELRHIRQKDHFECDICKRVFKTKTGLRHHIAVHTGEYKYCCDYCGRGFMSRMMMEEHRSMHTKEERYICDVCGRKFSFQSTYWIHRKWHDNPYPYKCSFCGRMFRHSSLLAVHKRTHTGERPYKCPHCPLTFPVGGTLKRHLILHTGVYPFNCENCKRGFTTRHKYATHLAKIHGDFEMLHAKPQQSEFKMVIRDEPKPIQQPTVWEVTDDSVPDQMNFKLETITGDDDRSKDPVHEGIACTIVSDEMLVDNMVPTRVVEIVLDETSQAVATVTLAEHANILPDIWYQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-