Basic Information

Gene Symbol
L
Assembly
GCA_012273895.1
Location
CM022612.1:3243734-3247813[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.39 26 5.4 5.8 1 23 3 25 3 25 0.97
2 16 5.3e-06 0.00035 20.7 4.1 1 23 31 53 31 53 0.99
3 16 1.6e-05 0.0011 19.2 0.1 1 23 59 81 59 81 0.98
4 16 2.3e-06 0.00015 21.8 0.1 2 23 97 119 96 119 0.96
5 16 3.9 2.6e+02 2.3 0.2 9 23 146 161 142 161 0.93
6 16 0.19 12 6.4 0.0 3 23 216 236 215 236 0.97
7 16 0.03 2 8.9 0.1 2 23 250 271 249 271 0.91
8 16 5.8e-05 0.0038 17.5 1.8 1 23 279 302 279 302 0.91
9 16 0.017 1.1 9.7 0.1 1 23 307 330 307 330 0.92
10 16 0.0037 0.24 11.8 0.2 1 23 390 414 390 415 0.94
11 16 0.00012 0.0082 16.4 0.1 2 23 464 485 463 485 0.96
12 16 0.036 2.4 8.6 0.0 1 23 493 515 493 515 0.98
13 16 5.6 3.7e+02 1.8 0.9 2 23 523 544 522 545 0.91
14 16 0.33 21 5.7 0.4 3 23 623 643 622 643 0.95
15 16 0.0035 0.23 11.9 0.1 1 20 651 670 651 673 0.95
16 16 0.041 2.7 8.5 0.2 1 23 680 702 680 702 0.96

Sequence Information

Coding Sequence
ATGCCGTTTCGATGCGAATTTTGTTCGagattatttaaacacaagAGATCTCGAGACAGACACGTCAAATTGCACACTGGCGATAGAAAATACCGATGCGCTCACTGCGAATCAGCGTTTTCCCGcagTGaccatttaaaaattcacatgAAGACGCACGACAATCAGAAGCCGTTTCAATGTACGGTGTGCAACCGTGGATACAACACTGCTGCTGCGCTCACATCCCACATGCAGGGCCACAAGCGTGACCGCGATGGGCGTGAAGTAGACCGACGAAGAGTTTTGCGATGCGTTCGCTGTGGAGAGAGCTTCCGGCGACCTGATATGTTGCAGGCACACATGACAACGGCCCATGGCGCTATTACCCCTCCTCGCCGCGTAGCTTCTCAACCACCGCCTACACTCCTCGCGTGTATTTATTGTACTCGTGATACATTCACCAGCATGGAGCAATTGCAGCTTCATGTTAGAGCATCGCATTCAGCCTTATTAAATGGTGAAGGTACAACAGTTACTGTGGAACAACCGGCTCCAACTGATTTAAGCCGTCGTGGCTCGGAAGGAACACCTCCAGTGAAACGGCCAAGGTCAAGCTCAGGATCGGCTACTCCTCAGACAGTTCTATCACCGAGTACTTTGCTGTGCAATCAGTGTGATGCAGCTCTACCAGATTTCGAAGCTTTCCGAGCCCATTTGAAAGGACATCTTGAAGAGGGTGGAAATTTAGCGCAAACAAGTCCTACGCCCTGTCTACACTGCGGGGCGACCTTCACAGATCCGGTCGCCTCAGAGCGTCACCTAGCAGCACATTATTTGGCAGTGTCATGTGAATATACGTGTCACAGTTGCGCTCGAAGTTTTTCTTCGCCGGATGACCTTCAGAAGCACCTTTTCGATCAACACGCCCATAGCCTATACCGCTGCACCCTTTGCAAAGAGATCTTCGAATCAAAAGTTGCCATtcaggtCCATTTCGCGGTAGCTCACAGCGGGGAGAACAAAATCTGGGTGTGTCGTTCCTGCGGGTCGAACGGGGGCGCGTTGCGTTCAGAAGCGGAGTGCGCGGCGCACGTGCGCAACCGGCACGCGGCGGCGCGGTGCGCGTGTGGCGCGGTGCTGGCCGGCGCGCGGGCCTTGCGGGAACACGCGGCTGCACACCACACCTACCGGTGTCCGGTGCCAGCGTGTACTGATACTTTCGCGGTACAGTACTTGCTGGAACGACATATGCAAGTCCATCACACTATTCCACAGGACGTCAACGGGGATATAATCCGAGCCAAGCAATCGGAAAACAACAATGCGTTAGAAAACGATTGTTCGCCGTGTCTTACTGGCGAGAACCAAACAGAGGAGCGTAGACGCAAGAACGGTGCTGTCGCGTTGCAATGTGCTTACTGCGGCGAGCGCACACGCAGTCGCGCTGAGCTGGAGGCTCATACACGAGCTCACTCGGGCAACACAGCTGCTAGACATAAGTGCCTCATTTGCGACGAAGTATTGCCATCCGCTGCTGTGCTCGCTGAACACAAGCTTACACATTGCAAGGTAGTGGCTGGAGATACATGCGCGCGATGTCGCTCTCGGATTACATCAGAAGAAGCGTATCTCACACACATGGCGCGCCACCATCCCGCCCTTCCCGCGCCTTGTATAATCTGTCGACAAACTTTGGCATCAGAGGCCGAGGCCCGACTTCACGCAAGGTTCCATCTCCGGCCTAACGAGGACGAGCAGCGGTGTGCTATCTGTTTAAAAACCTTATCAGAGAGTGAAACCGGTGAAGGCGTACGCGCATGCTCTTCATGCTATGCGAGGCATGCAGCGCCACGTCCTCCTCCGCCTCCCACCGCAGACAATGATTGTAGACTCTGTCGGCGTTCCCTAGAATCGCCAACTCGACTCCAAACACATCTCATAGAGCATACATTCGCTGGCATCGGTTCCTTCAGTTGCTACTTGTGTTCCGCCGTATTCACAAGCGCTGCTGGCTTGCAGCGGCACTTACCTGAACATCCCGCCGCTTCGAGACCCTATGACTGCGCTCGTTGTGGACTGAAGTTCTTTTTCAGGGCGGAACTTGATAACCATGCGTTAATTCATTTAGAAGAAGCAGAATTAGCTCAAAGAGCGTTCTATGAAGCGTATGCTAGAGGAGCTGCCTCGGCTTGGGCTGCGTTGCAATCTGATCCGTCTCCAAAGACCGTTACGGTTCCAGCTCCAGACGTTCAAGTTAAACAAGAGAATGAAATCAAGGAAGAGAGGAACGACGAATACATTGAAGTATCGTCGCCACCGCCTGTGCAACCAAGGTCAACCACACCTGTACCGCCCGTTGTGAAACAAGAGAAGCCTGatgaagattaa
Protein Sequence
MPFRCEFCSRLFKHKRSRDRHVKLHTGDRKYRCAHCESAFSRSDHLKIHMKTHDNQKPFQCTVCNRGYNTAAALTSHMQGHKRDRDGREVDRRRVLRCVRCGESFRRPDMLQAHMTTAHGAITPPRRVASQPPPTLLACIYCTRDTFTSMEQLQLHVRASHSALLNGEGTTVTVEQPAPTDLSRRGSEGTPPVKRPRSSSGSATPQTVLSPSTLLCNQCDAALPDFEAFRAHLKGHLEEGGNLAQTSPTPCLHCGATFTDPVASERHLAAHYLAVSCEYTCHSCARSFSSPDDLQKHLFDQHAHSLYRCTLCKEIFESKVAIQVHFAVAHSGENKIWVCRSCGSNGGALRSEAECAAHVRNRHAAARCACGAVLAGARALREHAAAHHTYRCPVPACTDTFAVQYLLERHMQVHHTIPQDVNGDIIRAKQSENNNALENDCSPCLTGENQTEERRRKNGAVALQCAYCGERTRSRAELEAHTRAHSGNTAARHKCLICDEVLPSAAVLAEHKLTHCKVVAGDTCARCRSRITSEEAYLTHMARHHPALPAPCIICRQTLASEAEARLHARFHLRPNEDEQRCAICLKTLSESETGEGVRACSSCYARHAAPRPPPPPTADNDCRLCRRSLESPTRLQTHLIEHTFAGIGSFSCYLCSAVFTSAAGLQRHLPEHPAASRPYDCARCGLKFFFRAELDNHALIHLEEAELAQRAFYEAYARGAASAWAALQSDPSPKTVTVPAPDVQVKQENEIKEERNDEYIEVSSPPPVQPRSTTPVPPVVKQEKPDED

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00430847;
90% Identity
iTF_00771246;
80% Identity
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