Basic Information

Gene Symbol
-
Assembly
GCA_949319315.1
Location
OX439386.1:14998970-15002542[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.047 2.6 9.1 6.6 1 23 57 80 57 80 0.98
2 19 0.02 1.1 10.3 2.7 2 23 149 171 148 171 0.96
3 19 0.031 1.7 9.6 1.7 2 23 177 199 176 199 0.93
4 19 0.024 1.3 10.0 1.1 1 23 204 227 204 227 0.94
5 19 0.2 11 7.1 0.5 2 21 234 253 234 256 0.82
6 19 2.4e-05 0.0013 19.4 2.9 1 23 263 286 263 286 0.91
7 19 0.00072 0.039 14.8 1.2 1 23 292 314 292 314 0.96
8 19 5.3e-06 0.00029 21.5 5.3 1 23 320 342 320 342 0.98
9 19 0.15 8 7.5 0.9 1 13 348 360 348 362 0.90
10 19 0.00051 0.028 15.3 1.7 1 21 410 430 410 433 0.89
11 19 2.4 1.3e+02 3.7 0.2 2 23 459 481 458 481 0.92
12 19 0.0046 0.25 12.3 0.1 2 23 504 526 503 526 0.96
13 19 0.032 1.8 9.6 0.4 1 23 536 559 536 559 0.90
14 19 0.4 22 6.2 6.0 1 23 564 587 564 587 0.86
15 19 8.9e-05 0.0049 17.6 1.9 2 23 593 615 592 615 0.96
16 19 0.00092 0.05 14.5 0.1 2 23 623 645 622 645 0.96
17 19 0.0015 0.081 13.8 1.6 2 23 652 673 651 673 0.94
18 19 0.00019 0.01 16.6 0.9 1 23 679 701 679 701 0.98
19 19 3.6e-05 0.002 18.9 1.7 1 23 707 729 707 730 0.95

Sequence Information

Coding Sequence
ATGTCTGAAATAAACAACGAACCAACGCCTAAAGTAGATCCTAAGAAACCCAGCTCGGCTGACCACGAGAAACAAGCCATTGCTAGCAAAAGGGCGCGTATTCGAGACAACCTACTCACACTGTTGGAGTGCAGCACTGTAGTGCCTTTCAGGCTCCGAGGAAAGACCTACAGGTGCTACCATTGCCAAATAAACTTCTGCAAAATCCAGCAGTTAAAGGACCACACCAAAACTGAACACGGCAATCCGAAAACCTTCGTGGTGAAGTCCGGTGGCGACGTCTTGCTAAAGCTCGAAGTTTCGGAGATAGAGTGCCGACTTTGCTCGTCAAAGATGGAGAATTTCGAACAGCTACTGCTCCATTTAATACTGGCACACGATAAGACCATAGAGCCggacatacaaaaatacattattCTGTTCAAACTCAGCGACGACGTTGTAAAATGCCTTCTTTGCGGCGAGGAGTTCATATACTTCCACTTCCTCCTCCGTCACATGCACAAGGAGCACACCGGGCAGGCTCTGAGCTGCGAATACTGCGGCATACACATGTCTACTGAGAACAGCCTGAAGCGACACAGGGAAAACAAACACGGGAACCAGAGGTACCCATGTCGATTTTGCGACAAAGTGTTTGCATCCACCCACAGCCGCGCCGACCACGAGAACCGTATCCACGGGGACGAGGCGGCCCGCCAGTGCCACATCTGCAACGAAGTCTTCGGAAGCAACTTCAAGCGAGACACTCACCTGGCGGCAGTCCATAACTTGTGGAAGACCAGATTTGAGTGCACAAAGTGTGGCAAGGTCTTCAGACACAAGCAGCAGCTCGTGAAACATGACAGGCGCATCCATTTGAAGGAGAAGAACTACACCTGTGACGTTTGTGGCTTCAAATTCTTCCAGACGTCCGAGTTGAAACTGCACTCCACCGTTCACACGGGGGAAAAAGCGCATGAATGCGAGCTGTGCAACAAGAGGTTCAGTAAAAAGAAGCACCTGATGGTTCACATGCGGATACATACGAACGATAGACGGTATGTGTGCAGTTTCTGCGACAAGGCGTTCGTTCAATCGACGAaACCAGAAGACACGTCTGACGATCATGACGACTCTCCTGAGCCTAGACTCAACGTAGAACAACAACGGAACCAGTTCAGAAATACATTTAAATACCTAGTGGAGCACACGAGTGTTATGCCTTTTAAATGGGTGGCCCATAGATTCGTTTGCTTTTACTGCGGTTGTCCATTCACCGATAGTGACAAGCTGAAAGCACATAATACCGAAGAGCACTCAACTGTTGAGTTTCGCCACCTTATGAGGACCATATCTATAAGAAACTCTATCAAACTAGACGTTACGGATCTCACTTGCAAATCGTGCCCGGTACATCTAGATTCTTTCGATGATTTACTGGATCACATAACGGAAGCGCATAAATTCGTAATTCATCAAACAATCAGAAAACTTTACGCGCCTTTTAAGTTGTCAGAAAACGGCATGCCATGTTCGGAATGCGGACTCCAATTCAGGTTCTTCGGGCCTTTAATAATTCACATGAACAAAGACCATCTCAATAAAACCAAATCTTCTGGGCGATTTCTGTGCGAAAAATGTGGCGCAGAATTCTGCAGCCAAGCAGGCGTCACGAGCCATGTTGAACAGTCCCACGCCGACACCAAGTACAAATGCAAGACGTGCAACAAGCTCTTCAAGTCTCACCTCAGATTACACGTCCACGAGAAGGAAACGCACAGCGTGAAAACCATTCAATGTTCCGAATGCCAACAAAGCTTCACGAGTCATTACATGCTGAAGCAACATCGGGCTACCGCTCACGACTGTACGGACTTCAAAGTCCCTTGTGGGGAGTGCAAAAAGACGTTTATTTCCAAAGGCCGACTAGATGAACACGTCAGGAGGGTGCATCTGAAGGAGAGAAAGCTTGTCTGCCAAGATTGCGGGTACCGGGCGTTTAACAACGACCACTTGAGACGCCACAGGGTGAAACACTCGGACCTTCGCCCGTTCGAGTGCGACGTTTGCCTGAAGGCGTTTCAGAGGAAGAAGACATTGGAGCTCCACAAGAGGATACACACGAACGACAAGAAATATGCGTGCAAGATCTGCGACAGAGCGTTCATACAGTATACTAGTCTTAAGCTGCACACTAAAGTCCACCATGGCAATGAATAG
Protein Sequence
MSEINNEPTPKVDPKKPSSADHEKQAIASKRARIRDNLLTLLECSTVVPFRLRGKTYRCYHCQINFCKIQQLKDHTKTEHGNPKTFVVKSGGDVLLKLEVSEIECRLCSSKMENFEQLLLHLILAHDKTIEPDIQKYIILFKLSDDVVKCLLCGEEFIYFHFLLRHMHKEHTGQALSCEYCGIHMSTENSLKRHRENKHGNQRYPCRFCDKVFASTHSRADHENRIHGDEAARQCHICNEVFGSNFKRDTHLAAVHNLWKTRFECTKCGKVFRHKQQLVKHDRRIHLKEKNYTCDVCGFKFFQTSELKLHSTVHTGEKAHECELCNKRFSKKKHLMVHMRIHTNDRRYVCSFCDKAFVQSTKPEDTSDDHDDSPEPRLNVEQQRNQFRNTFKYLVEHTSVMPFKWVAHRFVCFYCGCPFTDSDKLKAHNTEEHSTVEFRHLMRTISIRNSIKLDVTDLTCKSCPVHLDSFDDLLDHITEAHKFVIHQTIRKLYAPFKLSENGMPCSECGLQFRFFGPLIIHMNKDHLNKTKSSGRFLCEKCGAEFCSQAGVTSHVEQSHADTKYKCKTCNKLFKSHLRLHVHEKETHSVKTIQCSECQQSFTSHYMLKQHRATAHDCTDFKVPCGECKKTFISKGRLDEHVRRVHLKERKLVCQDCGYRAFNNDHLRRHRVKHSDLRPFECDVCLKAFQRKKTLELHKRIHTNDKKYACKICDRAFIQYTSLKLHTKVHHGNE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-