Basic Information

Gene Symbol
COPS7B
Assembly
GCA_949319315.1
Location
OX439395.1:11457494-11461721[+]

Transcription Factor Domain

TF Family
TEA
Domain
TEA domain
PFAM
PF01285
TF Group
Helix-turn-helix
Description
The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.0063 75 4.1 0.0 5 43 227 265 187 293 0.58
2 7 0.012 1.5e+02 3.2 0.0 5 45 266 306 260 333 0.81
3 7 0.014 1.7e+02 3.0 0.0 5 45 305 345 301 371 0.81
4 7 0.0047 56 4.5 0.0 5 42 383 420 339 459 0.60
5 7 0.011 1.3e+02 3.3 0.0 5 46 422 468 417 495 0.78
6 7 0.013 1.6e+02 3.1 0.0 5 45 461 501 457 528 0.80
7 7 0.011 1.3e+02 3.4 0.0 5 46 500 547 496 578 0.78

Sequence Information

Coding Sequence
ATGAATCCAATTTCGATGGATAAAGACGAGCCCTCATCGCTGCTTGCTTTCTCATCCAATCACCCGTTGGAGCAATTCTTGCTGTTAGCAAAAGGCGCGAAGGGCCAGGCATGTGCTGAGCTCATCAAACAAGTCCTAGAAGCACCAGGAGTCCACGTTTTCGGTGAACTTCTGGAGATGCCAAATATAACAGAGCTAGAAGACGGCCCGTATGCAACACACCTGAAGACGCTCAATCTCTTTGCCTACGGCACATACAAAGATTACCTCGAGAACAAATCGGACTACCTCGAGTTAACCTCGGCACAATGCAAGAAGCTACAGCACTTGACGATTGCGACGTTAGCTACACAGGAGAAGTGTATACCATACAGTGTGTTATTGAAAGAGTTGGACATTAAGAATGTTAGGGACTTGGAAGACTTGATTATTGAAGCTATTTATGCAGACATAATCCACGGCAAGCTCGACCAAGAATGCGCGCGCGTCGAGGTCGACGTCGCTTTAGGCCGCGACGCGCGGCTGGAGGACGCGGCGCGTATCGCCGACGTGCTCGGCGACTGGTGCGGCGCGTGCGAGGCCGTGCTAGCGTCCGTCGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTCGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTCGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTTGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTCGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTCGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTCGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTTGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTTGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCACCACATGCAGCGGGACCAGGAGGTAAGCGACTGGTGCGGCGCGTGCGAGGACGTGCTAGCGTCTGTCGACCAGCACATCCAGCGAGCCAACCAGCACAAGCTGCGCGCGAGGACGCATCACATGCAGCGGGACCAGGAGATCCTCCACATAAAAAAGACGTTGAACGTGCGCGCCGAGAGCGACGAGTCCGCCTTAGCCGGCGCCGAGAGCCACTCTGCACCCAAGAAGAGCTCCGGGAAGTCGAAGACGCCGCGCACCACCCCCAAGTTCTGGCAGAAAACCACCTAG
Protein Sequence
MNPISMDKDEPSSLLAFSSNHPLEQFLLLAKGAKGQACAELIKQVLEAPGVHVFGELLEMPNITELEDGPYATHLKTLNLFAYGTYKDYLENKSDYLELTSAQCKKLQHLTIATLATQEKCIPYSVLLKELDIKNVRDLEDLIIEAIYADIIHGKLDQECARVEVDVALGRDARLEDAARIADVLGDWCGACEAVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEVSDWCGACEDVLASVDQHIQRANQHKLRARTHHMQRDQEILHIKKTLNVRAESDESALAGAESHSAPKKSSGKSKTPRTTPKFWQKTT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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