Basic Information

Gene Symbol
zgc:66101
Assembly
GCA_018901805.1
Location
JAEIFH010000387.1:1958242-1972264[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.21 15 6.2 2.3 6 23 1725 1742 1724 1742 0.98
2 9 0.00051 0.036 14.4 2.8 1 23 1748 1771 1748 1771 0.93
3 9 0.00057 0.041 14.3 2.3 1 23 1779 1801 1779 1801 0.97
4 9 0.00025 0.018 15.4 0.4 2 23 1807 1829 1806 1829 0.96
5 9 0.52 37 5.0 0.1 2 23 1835 1856 1834 1856 0.95
6 9 0.43 31 5.2 2.1 2 23 1865 1886 1864 1886 0.91
7 9 0.00036 0.026 14.9 0.9 2 23 1894 1916 1893 1916 0.95
8 9 2.4e-05 0.0017 18.6 1.7 1 23 1922 1944 1922 1944 0.97
9 9 0.0037 0.27 11.7 8.9 1 23 1950 1973 1950 1973 0.98

Sequence Information

Coding Sequence
ATGGTGGCCATCAAGATCATTGATAAAACATGCCTGAACGAGGAATATCTGAGCAAGACTTTCCGCGAGATAGCGATATTGAAATCGCTGCGTCATCCGCACATCACACGCCTCTACGAGGTAATGGAATCGCAATCGATGATCTATTTGGTTACAGAGTATGCACCAAATGGAGAGATCTTCGATCATCTGGTGGCCAATGGACGCATGAAGGAGCCAGAGGCAGCAAGGGTCTTCATGCAACTCATTTCGGCTGTCAACTATTGCCATCAGCGCGGTGTAGTGCATCGTGATCTCAAGGCAGAGAATGTGTTGCTCGACAAGGACATGAACATTAAGCTGGCTGACTTTGGCTTTAGCAATCATTACGAGGAAGGCAGCCCCTTGCGCACCTGGTGTGGTTCACCTCCATATGCTGCGCCTGAAGTGTTTCAGGGACTGGAATACGATGGACCCAAGTCAGATATATGGAGTCTGGGGGTGGTGCTCTATGCACTAGTCTGTGGCGCGTTGCCCTTTGATGGCAAGACTATACTGGAGCTGAAGAGTCGCGTAGTGCTGGGCAAGTTTCGTATACCATTCTTCATGTCGCAGGAATGCGAGCACCTCATCAGAAATATGCTGGTGGTGGAGCCAGATCGACGTTATACCATCAAACAGATCATCAAGCATCGCTGGCTGAGTGATTGGCAGGCGGAGTTGCATCAGGAGGAACGCCCTGAGTTGCTTGGCTCACTGCCCTTTGGCACATCCAGTCCGTTAGGGAATTCCCTTACTGGTTCAAGCACTTCGCTGGCTGAGGCTGCACCTGTGGATATGTCTGCAGCGGCAGCACAACTCGATGCTGTTGTCATGACGCACATGTTGCAACTGCCTGGATTGACAGCGGACATGATTGCACTGTCGGTGCATGAGCAACGCTTCGACAACATCTATGCCATCTATAATCTGCTGCAGGATAAGCTGCTGCAGCGACGACGCGAAAACCAAAGACTGCAGCATCATGCGAGCCTTGCCTACTCCCGTTCACGCAAGACCAGCATTACAACGGGAGTTGTGGATCGTTCGGAGCCTGTCAAGCAGGAGTCCCTGGATCGTCTCAGTCCACTGAGCAATGCGAATGCATCTAATACAGCGCTGGGATTCGGTTGGTGCGCCGATGTGGGCGTGGATCTGGAGAAGTACGGGGAGTTTGAGCTGGAGTGTCTGGCGCGACCTAATGAGCCTCCTGTCAACCCGCAGCATTTGAGCGCCAGTGCTGGCGGTGCCAACGGTGCGAATACGCGACGTCATACAGTCGGACCTGGCGATGTGGCACATGAGCAAGCGCTGGCCAATCCCAATGTGCCGCCCATTGACTTTAAGTGTGCGCCACAATGCAATGATCCGGCGCAGGTGACGCCCTACTATCCCATGAATCTGCCCATGTTGCAGAATCAACCACTGCACAATTTGACCATCAAGGATCAGCATCTGCTCAAGCCACCCGTTGTTATGGGAGCCAGTTCCTTTGGTCGTCGTGCCTCCGATGGTGGCGCCAATCTGCACATTTATTATCCCGCCAGTGTGCCAGTTGGTGGCAATGTGCCTGGCGCTGCTGGTGTGGCAGGCGCACAGCAAATGGACACCTCTAGCTACTATATCAATCCCAATCTGAGTGCCACGCCTGGCGCCACAGAGCTGTCGCCTCTAAGTGAACAGCTGCCAGGGCAGCTGCACTGCTGTCCAGAGAATCATGGCGAGGAGTGCAGCGAGGAGATACAACGCTATATGCAGAAACGCGGCTGCGTCAAGCGCCACACGGTGGGCTGCACAGAGGATCTGTCGGTGAGCCACAGTCCTGGCGAGCTGGCGCATCTGCAGGTGCCGCCTGGTAGTGGACAGGCACAGTCGGGAGCCAGCAGTAGCTCTGCTGGTGGCAACATGCGCACACGCCGTACGGGTTTGCTAACTGTGACGGAGCGACCGCCAGTTATCTGCCCCGAGCTGATACGCGAAGTTGAATCTCGCATGAATCGCGACTATTTGCCGCCCACGCTTAAATCGCTCAGTCAATCCCCGCCAAATGCGCCCGCATTTGGTTTGCCAGTGGGCGTGGCCATGGGCATGGCTGGTGTTGCCACATCGCCGCATTCGCTGCCATTGAGCGTTGCCGGCGGTGGCAGCAATTCGGTGCCGCTGGTGGCACCACAAACGGCAGCAAACAATCGTCGCACCTATCGTGCAGCCCACTGTAAATTGCCCACTGTGCAGGAGGGTGCGACAATAGGACGCTACAGTCCGGTGCGTCGTGCCTCGGAGGGTTCGCGCTCACAGTTCCAGGGACCGCTGCAGGAGTGCCAATCCCTGCAAAAAGGTATCGCACAGAGAAATTTTTTGGTTGCACCAAGTCCGCCGCTTTTAGAAAATTCAATCAGTTTGCCAGGTTCCCCCATACATGGCAAGCCAACGAATCTGCAGCTCGCTTTACGTCGCGTTGGTCACGACATCGAAGTACCCCCGGAGGCCATTAAGACACTGATGCCTGCACTGGATCGTCTGGTCAAGGAGCAACGTGTCAGTTTCGAGATTGCCAACAAGATAATCTCATCGAATGTGGTGCCCATTGATCTGGCACCACAACTGGGTCTGGCTGCGCATGCCTCCAGCACTGCTGCTGTTAGTGGTGGCCATTTGGATCAGCAATCGCATCTGTTGCAGCTGCATCAGTTGCATCAGCAGCAGCCCATCCACAGCTACAGTGTGTCGCCGCTGACCTTGCCACATGGTGGTGTGGTGAATGCTTCACTTACCTCGGCTAAACAGATGTTCGGGCAACCCATTTGTGGTTATCAACAGTATCAGCCTCCAGCAGTGACGACGCTGATCTCCCCCTCGTCCTCCGCCGCGCAGCCACCTTCGGCTTTGGGGCTGACGTTGCCACTGCAACCGCAGCAACTGGTGGGGCAGTTTAGTAGCATCACGCTGGGCACCACCAACTCGAACAACAGCAGCGGCTGCCAGTCGCCCGTGTACAGCAGCAACAACAGCAACTCGAACAGCTGCAGCGGCTTCAGTGGCAGTTGCTCCCCCAATCCTAATCCCTATTTGCCTGGCACGGGTCCATTTAATCCCTGTGCAGCGGGTGGTTCATCTCCACTGCATCAGATTACCAAGGGCATTTCTGGACTGAGCACAGGAGGAGGAGGTGGTTCCATTACACGTGGCACTTCGGCAGCCAGCGAAGGAGCTGCACAACAGCCATTGGATCTGTCCATGGATGTGTGTAGTGTGGATCAATCTGTGGTGGCAGCGCCTGAATATGCCACGCCCAATTGGTTTATGCCTGCGGCGGCTTACTACGATTTGAAGCCATTGAATTTGTCGCCTGCGCAGCCTGTTAGGGTTGTGCCCACGCCCCCTGCCTCGCCCAATCTGTGCATCATACAGGAGGAGAATGGCAATGGGCAGATGTGCCACACCATCAGCACTGGCACGCCCTATGCAGGCTGCACGGGCGGGATCACGCCACAGATCTGCCTCACTGATGTGCAGGGCAGTGAGATCACACTCGTGGCGCTCTCCTCGGACAACAGTCGGGACAGTGAGGACTCGCTGGAGCCACACACGCCCATCATGTCGCTGCAGGGTCTGATCATTACGGAGCCCAGCAGCGACATGCCTTCCATTACACGTGGCATTGGACGCAAGGCGAGTCTGGACTGTGAGCCGGCGGCGACAACATCAACACATGCAACGAGCCACAGCAGCGCTGCCAGCACTGAGGCACATCGACGTGGCAGCGACAAGTCGTTGGGCTTCTCGGATGATTCCCTTAGCAACGATTCGAATAATTTGTCGCCTTCGTGCCAGGAACCTTCGGCCAGTTCAGGCTTCAAGTCAGACTCACATTCCGAGATGGGTGATCACACTGAATGCGGTCACCTGACGCCTGATTCCATGTGCGATTCACGTCGCATGTCAGATGAGATGTGCTACGAGGTGCCACTGCCACATGAATGCTCCAATCTGGACTCGACGAGGATACTGGAGATGGTTAAGCAGACCATAGATTCAACGATGCCCCCTAAGGGTTTTGTGCTGCACAAAGGGAGCATCAGTTCGGAGGACAGTGGAGCAGAGTCACGTCATAGCAGCGCCTCTAATGCATCCACCAGCGAGCTGACACACAGTTCGAGTGCAGGCACTGCCAATACGCATGTGGGAGTAGGAGGTGGAGCCACCTGCACAGGTTCCTCTGGCTACTGTGAACCCACCACCAATTTGAGTTTGGAATACTCGGGTGGTTTGCAGATCGAACTGCAGGTCTGCGAGGGACGCAGTCGGGATCATCATGGCGCTGCCAAAGGCATCAAGCTGCGTCGCATTTCAGGAGATCAATTCGACGCCAACGACACCATACAAATATTCGAGGGTGTTGGCTTGTCCCTGAACGTTGCCGTGGTGCTGGCCAAATACTTTTGGTTTCAGCCCAAAAGCGATGATCCCATATCGACAGAGATCTGCGTTGGCTGTTGGACACGTGTCAACGACTTCAACGAGTTCTACACGAGTGTGGAAAAGGCGCATCGTTTGCTCACCGAACGCTTCTCGTTGAAAGGAGGTGAGCAGCAAGAGAAGCTCCCGGCGAGCAGCCCGAAGCAGGAGCAGCCAAGCGATGAGTCCAAAGAGTTGTCTGACGATGACTTCATCGGGCAGGATGAGGCGCTGTATGTGGCAAGCGGCGGTGAAAGCGAAACAGCGGTCTCCTTCAGCAATGAACAGTTCCTCAACGATGTGCTGGCCACGCAGCAGCCCAGCGAGAAGTGTGAGGAGCAAGTTCCACAGCTGGAAGCACAGCCTGAGCGCCGTGAGACACGCGCTACACGTGCCAAGAGCAAAGCCATGAATGAATCTCTGCCGCCGCCAGCTGTGAAAGCATCGACCACGACCGCTGTTAAACGTCGTGGCAGATCGAAGTCTGAGAAGTCCAGCAAGGAAGTTAGCAGCATGGAGGAGGTGCCAAAGAGCAAGCGCTATGTGGACTACAAGAAATCTATGTTGGAGATTGATGCAAAGATAGCAAAGCACATGCGGCTCACCTGCAACGTGTGTCACGAAGTGCAGGAGACCTTCCTGCTGCTCTGCAAGCACATGATGCAGACGCATCACTGCAAGGGCTACGCCATGTGCTGCAACAAGAAGTTCTACAAGCGTTCCTTTCTCACCGATCACATTGATCGTCACTCGAATCCCGAGAAGTTTAAGTGTGATCTGTGCGACAGAACCTTTGCGGACAAGCAGTGCCTGCGCAACCATGAGCTGCTCAAGCATCAGCCGGACGAGCAGAAGATCTTCATGTGCGAGCACTGCCCCAAGCGCTATACCAAGCAGTATTTGTTGGATCAGCATCGCATCATACACAAGGAGCGCAATGTGCCCTGTGATATATGCGATAGACGCTTTCCCAACGTATCCATGCTCTGCACGCATGTAAAGATGGTGCACGGCAATTATGGCACCATGTGCGACATCTGTGCGCAGGTCATACGAGGACGTGCTGCTTTTCAGCGTCATCAGCTGGAGCACGCTGGCATTACAGAGCCCAAGGTGCAGTGTGATATCTGTGGTTCGTGGCACAAGAACAAGTACAGTCTGAAGAAGCATGTGCGCCGGCACAATGGTTCTTCGGAGGAATGCACTTGCAACATCTGTGGCAAAGTCTCCCCCAATCGCAGTGCGATGCTCAGTCATCAACGTTATGTGCACAACGCTGATCGTGTGCACGTGTGCAGTGTGTGCTCCAAGAAGTTCAAGAAGGCCATCAATCTCAAGGAGCACATGGCCACGCACACTGGCGAGGTGCTCTACAAGTGTCCACACTGTCCCAAGACCTTCAATTCGAATGCCAACAAGCATTCGCATCGCAAGAAGTGTCATCCCAAGGAGTTCGAGGAGGCGCGCAAGGCACGCATGCAGAATCGCATGGCACCCGTGCAGGCAGGGGAAACCAAGTCCAGTTTGATTACCATCACCACCACAGGTGAGACAGATGGGCAGCTGGAGACGCACAACATACTTGTGACCACAACGGAGGACACTGAGGATCAAGAAGGGTTTAAGGGTGAAGAGATTGACTTTATGCTCTCGCTCAGTCCGCAGCCGGCGACGGAGTAA
Protein Sequence
MVAIKIIDKTCLNEEYLSKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFMQLISAVNYCHQRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGSPLRTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEHLIRNMLVVEPDRRYTIKQIIKHRWLSDWQAELHQEERPELLGSLPFGTSSPLGNSLTGSSTSLAEAAPVDMSAAAAQLDAVVMTHMLQLPGLTADMIALSVHEQRFDNIYAIYNLLQDKLLQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASNTALGFGWCADVGVDLEKYGEFELECLARPNEPPVNPQHLSASAGGANGANTRRHTVGPGDVAHEQALANPNVPPIDFKCAPQCNDPAQVTPYYPMNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPASVPVGGNVPGAAGVAGAQQMDTSSYYINPNLSATPGATELSPLSEQLPGQLHCCPENHGEECSEEIQRYMQKRGCVKRHTVGCTEDLSVSHSPGELAHLQVPPGSGQAQSGASSSSAGGNMRTRRTGLLTVTERPPVICPELIREVESRMNRDYLPPTLKSLSQSPPNAPAFGLPVGVAMGMAGVATSPHSLPLSVAGGGSNSVPLVAPQTAANNRRTYRAAHCKLPTVQEGATIGRYSPVRRASEGSRSQFQGPLQECQSLQKGIAQRNFLVAPSPPLLENSISLPGSPIHGKPTNLQLALRRVGHDIEVPPEAIKTLMPALDRLVKEQRVSFEIANKIISSNVVPIDLAPQLGLAAHASSTAAVSGGHLDQQSHLLQLHQLHQQQPIHSYSVSPLTLPHGGVVNASLTSAKQMFGQPICGYQQYQPPAVTTLISPSSSAAQPPSALGLTLPLQPQQLVGQFSSITLGTTNSNNSSGCQSPVYSSNNSNSNSCSGFSGSCSPNPNPYLPGTGPFNPCAAGGSSPLHQITKGISGLSTGGGGGSITRGTSAASEGAAQQPLDLSMDVCSVDQSVVAAPEYATPNWFMPAAAYYDLKPLNLSPAQPVRVVPTPPASPNLCIIQEENGNGQMCHTISTGTPYAGCTGGITPQICLTDVQGSEITLVALSSDNSRDSEDSLEPHTPIMSLQGLIITEPSSDMPSITRGIGRKASLDCEPAATTSTHATSHSSAASTEAHRRGSDKSLGFSDDSLSNDSNNLSPSCQEPSASSGFKSDSHSEMGDHTECGHLTPDSMCDSRRMSDEMCYEVPLPHECSNLDSTRILEMVKQTIDSTMPPKGFVLHKGSISSEDSGAESRHSSASNASTSELTHSSSAGTANTHVGVGGGATCTGSSGYCEPTTNLSLEYSGGLQIELQVCEGRSRDHHGAAKGIKLRRISGDQFDANDTIQIFEGVGLSLNVAVVLAKYFWFQPKSDDPISTEICVGCWTRVNDFNEFYTSVEKAHRLLTERFSLKGGEQQEKLPASSPKQEQPSDESKELSDDDFIGQDEALYVASGGESETAVSFSNEQFLNDVLATQQPSEKCEEQVPQLEAQPERRETRATRAKSKAMNESLPPPAVKASTTTAVKRRGRSKSEKSSKEVSSMEEVPKSKRYVDYKKSMLEIDAKIAKHMRLTCNVCHEVQETFLLLCKHMMQTHHCKGYAMCCNKKFYKRSFLTDHIDRHSNPEKFKCDLCDRTFADKQCLRNHELLKHQPDEQKIFMCEHCPKRYTKQYLLDQHRIIHKERNVPCDICDRRFPNVSMLCTHVKMVHGNYGTMCDICAQVIRGRAAFQRHQLEHAGITEPKVQCDICGSWHKNKYSLKKHVRRHNGSSEECTCNICGKVSPNRSAMLSHQRYVHNADRVHVCSVCSKKFKKAINLKEHMATHTGEVLYKCPHCPKTFNSNANKHSHRKKCHPKEFEEARKARMQNRMAPVQAGETKSSLITITTTGETDGQLETHNILVTTTEDTEDQEGFKGEEIDFMLSLSPQPATE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-