Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00089 0.081 13.7 0.0 3 23 182 203 180 203 0.96

2 6 1.2e-06 0.00011 22.7 1.4 1 23 210 233 210 233 0.94

3 6 0.00018 0.017 15.8 0.6 2 23 251 272 250 272 0.96

4 6 0.0092 0.83 10.5 1.0 1 23 278 300 278 300 0.96

5 6 7.6e-05 0.0069 17.0 1.6 1 23 307 330 307 330 0.98

6 6 0.00051 0.047 14.4 4.2 1 23 336 358 336 358 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00089	0.081	13.7	0.0	3	23	182	203	180	203	0.96
2	6	1.2e-06	0.00011	22.7	1.4	1	23	210	233	210	233	0.94
3	6	0.00018	0.017	15.8	0.6	2	23	251	272	250	272	0.96
4	6	0.0092	0.83	10.5	1.0	1	23	278	300	278	300	0.96
5	6	7.6e-05	0.0069	17.0	1.6	1	23	307	330	307	330	0.98
6	6	0.00051	0.047	14.4	4.2	1	23	336	358	336	358	0.98

Coding Sequence: ATGTTGAATTTAACAAACATTTCCGAACTATGCCGAATTTGCATGCGCCATCTGCGCCAGCTAAACGATCAGCAACATGCAACAGCAGCAACAACAACAACAACTGACAGCCAATACACACAACGCCACAGAGCCAGTTACAACTCAAAGGCTCTGCCCCATTTGGCCAAAATGTTGAATCAGTTTTTTGCCATTGACGTGTTTAAGCAACCGGACACCTTTCCACAGAACATATGCACACTGTGCTACAATGCCCTCGAATATTTCCAGCAACTTTGCACCGTGGCCGAGCAGAGCAATGAGATGTTGACACGCATGGCAAGCCCAGCGCAGGCCCATCCCCAAGACGCCTCTGATGCCGACGCTGACGCTAACTTGTTATCGCTCGTGAAAGAGGAGCCATGGAAGCCCATGGAAGATGAGCCCCAGACGCAGTCGCCGTCGCAGCCAGCATACGATTCCGAGCTGGAGGATGGCACAAGATGCACAGCAACAGATGCCGCCGCCAGAGCTGAGGCGGCCAACAAACGCAAGCTGCTCGCATGCGAGCAATGCGGCAAGCAGGTGTACAAGCTACCTTATCTGGAGGCACACATACGCAGCGTGCACGAGGGTCATCCAAAGCCGTTTCTCTGCAGGAATTGTGACAAAGCATTCACACGCTATGAGCAGCTGCGATCCCATATGCGCAATGTGCATCCAGCAGTTGCTGCCGCTGCTGCAGTTGCCCCCAACGAGGAGCTGGAGCTGATCTGTGAGCAATGCAATCGCCGGTACAGTACCAAGAATGCGCTGGGCGAGCATCTGAAACGACATGCCCAGGAGAGGCCGCACATATGTGAGCACTGCGGCGCTGCAAAGGTGACACGTACCGAACTGCTCACCCATCTGCGCATCCACAATCCCGACTGGGAGAAGTTCAAGTGCAACCAGTGTCCGCAGCTCTTTCGCCACAAGAGCGCAATCAGTCGCCATGTGCGCGTAGTGCACGAGGGTCAGCGGCGTTTCCAATGTGGTCACTGTCCCAAACGCTTCGGTACACATGCCTCGCAGCGCCGACACGAGCGATTGCACGTCGACACGTTTTAA
Protein Sequence: MLNLTNISELCRICMRHLRQLNDQQHATAATTTTTDSQYTQRHRASYNSKALPHLAKMLNQFFAIDVFKQPDTFPQNICTLCYNALEYFQQLCTVAEQSNEMLTRMASPAQAHPQDASDADADANLLSLVKEEPWKPMEDEPQTQSPSQPAYDSELEDGTRCTATDAAARAEAANKRKLLACEQCGKQVYKLPYLEAHIRSVHEGHPKPFLCRNCDKAFTRYEQLRSHMRNVHPAVAAAAAVAPNEELELICEQCNRRYSTKNALGEHLKRHAQERPHICEHCGAAKVTRTELLTHLRIHNPDWEKFKCNQCPQLFRHKSAISRHVRVVHEGQRRFQCGHCPKRFGTHASQRRHERLHVDTF

Sequence clustering based on sequence similarity using MMseqs2