Basic Information

Gene Symbol
ush
Assembly
GCA_035044505.1
Location
JAWNNX010000029.1:1960850-1965292[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.037 3.1 8.6 0.0 1 20 280 299 280 301 0.90
2 9 0.00028 0.024 15.3 0.8 1 23 356 378 356 378 0.98
3 9 0.047 4 8.2 1.0 2 21 421 440 421 441 0.92
4 9 0.049 4.2 8.2 2.9 2 21 827 846 826 847 0.93
5 9 0.0091 0.77 10.5 0.0 3 21 895 913 893 914 0.91
6 9 0.0065 0.55 11.0 0.0 2 23 985 1006 984 1006 0.98
7 9 0.0038 0.32 11.7 1.3 1 23 1012 1034 1012 1034 0.99
8 9 0.00044 0.037 14.6 0.9 1 23 1094 1117 1094 1117 0.96
9 9 0.3 26 5.7 0.7 2 20 1225 1243 1224 1245 0.91

Sequence Information

Coding Sequence
ATGCCTTTGCGGGATAAACATCCAAACATTCGAACATCCAAGGAACCACAGATTCCACTGGTCGACTGGTGGAACGGTCACTTGGTCGATTGCTCGATTGGCCGATTGGCCGACAACCTCGAACTCTGGTCTTTTCTGAAATCTCTAGCTATGAGCCTCGAGTCTCGTCTTGGACAACGTCGCATTGTTTTCTCAGCCGCCTGTCGCTTCACTCGCGCCGCTGACAATTTGTTCGCTTATAATTGCGATCCTCTGGCCACATTTGACTTCTGCCAGCGACTCGCTCATGGGGATTGTCTTTCAAAGAATTCCAAAGACTTAGGAGCACAAGAGCTCAGCGAggagaagcggcagcagcagcaaatggaaGAGCAGTCCATGGACGAGGAAATAGAGAACCAAAACAGCAACGCTTCTGAGCAGCCCATGGAAACCGACATGGAgcaggacatggacatggtcGAGGCTGAAGCCGTGCAGGAGTTCAACGAACAGCAACTGCACCGGCAGAAAGATGCCGACAACTCGACGACTCCACCTCGTAGTCCAACGCCTGAGCTGGTGCCCAAGATAGAGATGGCTGAACCCCCAGCGACGCCGCCCTCTGGCACCGCCACTCCGAGCCCCCCGCTCACTCCCACGCCAACTCTTGTACTGCCAAAGCTGCGCCTAAACGCCCTGCTCGCCTCTGATCCAGCACTGAAACCAGACGCAAAGGAGCTGACCTTACCGGAGCCCCGGCTCTTGGCTCCTCCACCACAGTTGACGAAGCCCGAGCCGCAGCAGAGTCTATCGGATCCGGGCAACCTCGTCGAGCCGCTGTTGAAACCGGCACGCTTTATGTGCCTACCGTGTGGCATTGCCTTCAGCTCGCCCTCGACCTTGGATGCGCATCAGGCTTACTATTGCTCCCATCGAAACAAGGAAGCGGACGAGGAGGCAGCCACCGGCGACAAGTCGCAGTCGACAGCAAGTGGAGGCTCCTCCAGCgcaaccaacagcagcaacagcagcggcggcagtggcTCCGAGCCGCCTTCCAAGGTGGCACGCACTGGCAAGCAATACGCCTGCACTCAGTGCTCCTACAGCGCTGACAAGAAGGTCTCCCTCAACCGGCACATGCGGATGCACCAGACGTCCCCGGCCCCCAGTCTGTCCACGTTGCCCACGCTGGCCAGCATGACGTCCCTGACCGCCAATGGAGTGTCAGCCGGAGGCAGCTCGCTCGAGGAGAGTCCTAGTCAACAAATCGATCGCTACTGCAGCGACTGTGATATCCGCTTCAACAATGTGAAGACCTACCGCGCCCACAAGCAGCACTACTGCAGTTCCCGGCGCAGCGATGGGCAGCTCACGCCCAAGCCGGAGGTGGTTGCCGGAACCGGAGCAGGTGCTGGTGTTACGGCCCCGACTGCAGCTGCCGTTGTGGCAGGAGGAGGCAAAATGAGCGGCGCCCACAGCCCGCAGACACGGAACAAAACGCCAACACCCGCAATggttgcagctgccgcagcagcggcggccgcCGCAGCCGCCGCTGCCTCTCTGCAGGTGACACCCCCTCAGCCCTTCCTCGCTCTGCCAACCAATCCCATCATCATTGTGCCCTGTTCACTTATTCGTGCAGCCAGCCTAATACCGGGACCGCTAACCACCTCCACGTCGGGCATTGTTAATCCGGAGTCCACGTGCTTCACGCTCGACAATGGCGCTCTTAAGCCGCTGGCCACGGCCTTGAACATCAACGCGCTGGCCGgaaatgccacgcccacgatGACCAGCAGCAACCAGGTGCCTGTTTCCGCACAGGAATCCGATCGTCAGACCACATCAAGTGTGCACACCCAGGAGACGGAAATCAAGAGTAGTCCACCCGAGCCCAAGCGCAAGGAAACGAGCGGCACCCGAGAGACAACACCCCTCGATTTGTCTCTTCGACGCTCTCCCATTTCCGCTTTGCTGCAGCGCCAGCGCCTTGTGCGGTCAGCAGCCGCCATGTTGGAAGCTGAGGAGACGATGCAGGGCCCAGGCAAGGAAAATATCGAAAGTAGAGGCAGTGTCACTCCTGAGCAAATCGTATGTGCCCCCTCGCTGCCCAGCAGCCCATCCATGAGTCCTTCGCCCAAGCGCCGCACCATCAGTCCACGCAGCTCTGGTCCTGGCAGCGCTGCCTCCATGTCGCCCCCAACGCTTAATGTAGGGGTTCCACATCTTCTGGACAACCTGACACCACTGCGATCAATGCTGCCCGCCGACTTCGCATTATCCGAGTCGCTCCTGGCAAAGACCAATCCAGAGCTGGCGCTCAAGTTggcggctgcagcagccgccgcagtGGCCGGCAGCAGCTCAGCCGAGCTGGCCAGCAAACTAGGCTTCTCACCAGCTACGGCAGGCGCCGCTTCCGTGTCGGCTCCCTCGGCATCAAACACATCAAGTGCCCAACCACAAATCTACGTCAAGCAAGGCGTCTCCAAGTGCAAGGAGTGCAACATCGTCTTCTGCAAATACGAGAACTACTTGGCCCACAAGCAGCACTACTGCTCCGCACGCAACCAGGACTCAAGTGAAGGAGAGCCAAAAACGGCAGGGACTCCACCAGGCGGAGTAGCATCTGTTGGTGGCGTTGGAGCTGTGTCACCATCGGATGGCACGCCCGTAGCATATCAGCAGCTGATTTGTGCGGCGTGCGGCATAAAATACACTTCGTTGGACAACCTCCGCGCTCACCAGAACTACTACTGCCCTAAGGGTGGTGCGGCAGCCACACCCGTGGATGCAGCGCCGGCACATCTGTCTCTACCCAAGGAGAAGTGCAGCAAGTGTAAGACACTACACGAACCTGGACTACCCTGCCCGCCACCTGCAACGCCCCAAATGCCCCAAATACAGTCACATGCCAATCCATGCTCAGGTCCTTCGGCAGCAGCGTCCTCCAACAGTGTAAACAAGTGTCCAGTCTGCGGCGTGGTGAGTCCCACAGCGGCCCTGGCTCGAAAGCACATGGAAATGCATGGCACCGTGAAGGCCTTCCGTTGCAGCATCTGTCAGTACAAGGGGAACACCCTTCGTGgcatgcgcacacacatacgcacccATTTCGAAAAGAAGACCAGCGATGTGAACGAGGAGCACTACATGACTTGTATTTTTGAGGAAGACGCCGTCACCCCAACTAGTGTCCTGAACCACGGCCTCGGCTTGGAGCTGCCTACTATTCCGGTGGTGccgcaagagcaacaacaacttgatcagcagcagcatccgtCACAGCTCTTCAACTGCGACTACTGCAACTACGTCTCCACCTACAAGGGCAACGTGCTGCGTCACATGAAACTACTGCATCCCCAAGCAGGGATTGGTTCACCTTCGATATCGCCGGAATCACGTGATCAGGAGACACTTCCGATGTCCGATGTAGCCCTAGTGAACGGGGAGCGGGACCTGACTGCCGTGACTAGctttaaaatcaaagcagaGCCCGGGGAGCAGCCACCTATGACAGCTAACTTGGTGCATGAGAACAACAACTCACCCATTGGAACACCCCATACGCACATCAAGGCTGAACCCATTGATCTGGGCATCGATATCTCGCCACAACCTCTACCGCCACCAGTCTCAAACTCGCCGCTGGGGCCAAGCGCCGCCGAAGCCATGAAGAAATACTGTTCCACCTGCGACATATCTTTCAATTACGTGAAGACCTTCCTGGCCCATAAACAGTTCTACTGCAAGAGCAAGATGCACCGGCCAGAGCCCAACGATAGTCCCAGCCCCAACCATGTGGCTGCAAACGTGGGTGCATCGATACCGCTGCAGTCCCCTAATGATCTTCTGTTGCTGCAGAAGAACAAAGAGAATATGCAGGAGGCGGCCATTTGA
Protein Sequence
MPLRDKHPNIRTSKEPQIPLVDWWNGHLVDCSIGRLADNLELWSFLKSLAMSLESRLGQRRIVFSAACRFTRAADNLFAYNCDPLATFDFCQRLAHGDCLSKNSKDLGAQELSEEKRQQQQMEEQSMDEEIENQNSNASEQPMETDMEQDMDMVEAEAVQEFNEQQLHRQKDADNSTTPPRSPTPELVPKIEMAEPPATPPSGTATPSPPLTPTPTLVLPKLRLNALLASDPALKPDAKELTLPEPRLLAPPPQLTKPEPQQSLSDPGNLVEPLLKPARFMCLPCGIAFSSPSTLDAHQAYYCSHRNKEADEEAATGDKSQSTASGGSSSATNSSNSSGGSGSEPPSKVARTGKQYACTQCSYSADKKVSLNRHMRMHQTSPAPSLSTLPTLASMTSLTANGVSAGGSSLEESPSQQIDRYCSDCDIRFNNVKTYRAHKQHYCSSRRSDGQLTPKPEVVAGTGAGAGVTAPTAAAVVAGGGKMSGAHSPQTRNKTPTPAMVAAAAAAAAAAAAAASLQVTPPQPFLALPTNPIIIVPCSLIRAASLIPGPLTTSTSGIVNPESTCFTLDNGALKPLATALNINALAGNATPTMTSSNQVPVSAQESDRQTTSSVHTQETEIKSSPPEPKRKETSGTRETTPLDLSLRRSPISALLQRQRLVRSAAAMLEAEETMQGPGKENIESRGSVTPEQIVCAPSLPSSPSMSPSPKRRTISPRSSGPGSAASMSPPTLNVGVPHLLDNLTPLRSMLPADFALSESLLAKTNPELALKLAAAAAAAVAGSSSAELASKLGFSPATAGAASVSAPSASNTSSAQPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQDSSEGEPKTAGTPPGGVASVGGVGAVSPSDGTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGAAATPVDAAPAHLSLPKEKCSKCKTLHEPGLPCPPPATPQMPQIQSHANPCSGPSAAASSNSVNKCPVCGVVSPTAALARKHMEMHGTVKAFRCSICQYKGNTLRGMRTHIRTHFEKKTSDVNEEHYMTCIFEEDAVTPTSVLNHGLGLELPTIPVVPQEQQQLDQQQHPSQLFNCDYCNYVSTYKGNVLRHMKLLHPQAGIGSPSISPESRDQETLPMSDVALVNGERDLTAVTSFKIKAEPGEQPPMTANLVHENNNSPIGTPHTHIKAEPIDLGIDISPQPLPPPVSNSPLGPSAAEAMKKYCSTCDISFNYVKTFLAHKQFYCKSKMHRPEPNDSPSPNHVAANVGASIPLQSPNDLLLLQKNKENMQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-