Basic Information

Insect: Zaprionus indianus
Gene Symbol: run
Assembly: GCA_018904595.1
Location: JAEIHA010000158.1:10626755-10658520[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.7e-50 1.5e-46 157.0 0.0 4 94 27 117 24 122 0.96

2 2 6.3e-18 2.6e-14 52.8 0.3 92 129 131 168 125 168 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.7e-50	1.5e-46	157.0	0.0	4	94	27	117	24	122	0.96
2	2	6.3e-18	2.6e-14	52.8	0.3	92	129	131	168	125	168	0.94

Sequence Information

Coding Sequence: ATGCACATTTCAGCTGAGCCCGTGGACACGAGTCCCTATCTGACGCCAGAGAACCTGATCGAGCGCACCGTCGATGTTCTGCTGGCCGAGCATCCCGGTGAGCTGGTGAAAACCGGATCTCCCCACGTGGTCTGCACCACATTGCCCACGCACTGGCGCTCCAACAAGACGCTGCCCATTGCCTTCAAGGTGCTGGCACTGGGCGAGGTCATGGACGGCACCATTGTCACCATACGCGCTGGCAATGATGAGAACTTCTGCGGTGAACTGAGGAACTGCACGGCCGTCATGAAGAATCAGGTGGCCAAGTTTAATGATCTGCGCTTTGTGGGACGCAGCGGACGAGAGACGCAGACGGAGACGGAGCCCGAGACCAAGCGCAGCCCTTGTCAGGGCAAAAGCTTCACGCTGACTATTGTCATCTCAACGAATCCCATTCAAATCGCCACTTACACAAAAGCCATCAAGGTGACCGTGGATGGTCCCAGGGAGCCGCGTTCAAAGGTGCGTCATCAGGGCTTTCATCCGTTTGCCTTTGGACCTCAGCGCTTTGGCCCCGATCCGCTTATGGCTGGTCTACCCTTCAAGTTGCCAGGCTTCGCACATCACCTGGTGGGCATGCACAGTCACCTGCATGCGCCCGACTGGCGAGCTCACATGGCGCTGGGCGGACGGCCTGGCTTCCCTGCCGGACCCTTCTTTGCGCACCATCACGGCGCAGGCTTCCCAGCCAGCGCGGCGGCCGGAGGATTGCGTGGACTGAGCGATAACCAGCAGCAGCAGTTGGCGACAGTGGGTGCGGCGCATAGTACCACCAGCCCGGAGGGATCGCCGACGACCACGACCAGCGCCACGCTGAGTGCGTTCGTGCAGCCGACGGTGTGTGGTGCCAGCGCGGGCGGATCGCCGCCGCCGCCGTCGCTGACGCTGAGCAGCATGCAGCACCACGACAATAACAACAACAACAGCAGCAGCAATATCGATGCGGGATTCGAGAGCGACAGCATCTCGGTGACGGGATCGCCGAGGAAGAGCATCAGCTCGCTGACGCACGACGAGGAGGAGCCCGATCCGGAGGCGGGACGCAGTCGCAGTCCAACGTTGCTCAGTGCCGATGCCAGCAGTGTGGCAACGCTGGCCGAACCATTGCCCAGCAGTGGCAATGCTGCGACAGGCGGTGGCGCTGCAGGCGGAGGAGGCGCAGCAAGAATCCCACAGAGCTCTTCGGCGGATTCGCTGCTGCCGCGTTGCGTCACACTGATCACACACAATCCGCCGGATGCCGAGAATGCCAATCCAAATGCATCGCCCCCGGTCAGTTCCACACGGCGCTCGCCCTCGCCCGTGGAGACCATCGATCTGGATGACGTCAGCACCACATCGCGCTCGGCCAGCGGCTCCAGCGGCGCAGGTGGACCCATACGCACCCGCACGCCCAAGCCGACGTCGGACGTCTGGCGCCCCTACTAG
Protein Sequence: MHISAEPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRETQTETEPETKRSPCQGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALGGRPGFPAGPFFAHHHGAGFPASAAAGGLRGLSDNQQQQLATVGAAHSTTSPEGSPTTTTSATLSAFVQPTVCGASAGGSPPPPSLTLSSMQHHDNNNNNSSSNIDAGFESDSISVTGSPRKSISSLTHDEEEPDPEAGRSRSPTLLSADASSVATLAEPLPSSGNAATGGGAAGGGGAARIPQSSSADSLLPRCVTLITHNPPDAENANPNASPPVSSTRRSPSPVETIDLDDVSTTSRSASGSSGAGGPIRTRTPKPTSDVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01551496; iTF_01557337;
90% Identity: -
80% Identity: -