Basic Information

Insect: Zaprionus ghesquierei
Gene Symbol: Runx1
Assembly: GCA_018904095.1
Location: JAEIGP010000394.1:16294346-16309248[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.9e-73 7.7e-70 232.3 0.0 3 129 13 139 11 139 0.98

2 2 1.8 7.1e+03 -3.6 0.0 68 91 517 541 513 545 0.74

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.9e-73	7.7e-70	232.3	0.0	3	129	13	139	11	139	0.98
2	2	1.8	7.1e+03	-3.6	0.0	68	91	517	541	513	545	0.74

Sequence Information

Coding Sequence: ATGACCTCGGACATTCTCGCGGAGCGCACCCTCGGCGACTTCCTCACCGAACATCCCGGCGAACTGATTCGCACCAGCAGCCCCCTCTTCGTCTGCACCGTCCTGCCGCCGCATTGGCGCTCCAACAAGACGCTGCCGGTGGCCTTCAAGGTTGTCTCGCTGGGCGACATCATGGATGGCACCATGGTCACGGTGCGAGCGGGCAACGATGAGAACTATTGCGCCGAGCTGCGCAACTGCACCGCCGTCATGAAGAATCAAGTGGCCAAGTTCAACGATCTGCGCTTCGTGGGACGCAGCGGCAGAGGGAAGAGCTTCACGTTAACCATCACCGTGTCAACGAATCCTCCACACATCGCCACCTACAACAAGGCGATCAAAGTGACTGTCGATGGGCCGCGTGAGCCACGCTCCAAGACCATGCTATCCCTTTTAGGGCAACAACAACAATTTCACTTCGCCTTTGGCCAGCGACCGTTTCACTTCTCAACGGATCCCCTCTCCGGCTTCCGCATGCCGCCGATCGGCAACTGTCAGAGTGCCAGCAACACGCACTGGGGCTATGGATCGGCGGCCTCTGCTTATTCGCCGTACTTGGCCAGCAGCGGTTTATCGTCGTGCACCACGCCCACATCGGCACAGTTCAACAATCCGGCGCTGGGCTTTACCTGCTCCTCGAACGATCAGAGCAACAACCAGGACTTTGGCGGCGCCACCAATCGCGACTGTGTGCCAATGCTCCCCGATTCCACGGCCAGTGACCTAGACCAGCATCTAAGCAGCCTGGTCGGCTCCACCAGCGGCCAGATGTCACATCATAGCCTACTGGGAGCCAGCGGTCAGACATCGATAACATCGACAGTGAACGGCGCCAGCGCTGGCAGCGGAGCCACCTCTGGCAGCGCAGCGGGTGCCGGCAGCGGCGCTGGTGCCAACTCGATCCTGGTGCCGCGCTATCACACGAACGCTAGCAACGAGTACAACGTGCACTCCAGCCAGAACGGTCCGCGCAGCCTCAGTGACAGCTCGCAGGCCGAGTCGCCGGTGCAGGAGGATCTGCTCTCCACAAACACTCCGAATCTGGGCAGCGGCAGTGGCGGCGGCGGCGGTGGTGGGGGCGGTGCAACCAATGGTGGTGCCGCAAATGGCGGTGCTGGCAGTGCAGCGGGCGCTGGCAGTGGCGGCACAGCGGGCACTGCTACCGGTGCCGGAAATCCCGCCATGCTGGGAACCAATCAGAACTTTCCGGGCATTGTGAATCAGACCCAACATGCCTCCGCCTCGGCCTATGGCGGCGGTGTTGGTGTCGGTGTCGGAGTCGGTGTGGGCGGCGGTCATGGCGGCAGCGCTGGTGCCACGGCGGCCGGCTGCAACGGATCACTGTATCCGGTACTGCCCGCCAGCCTGCTCTACTCGCAGCTCTACACGGCCGCCAATCAGTCGGCGCATGGCTTCCATTCGCACACACTGCCCGCTCACGCATCGCCCAACTCGTCGGTGCATGGCGAGCTGCAGAGCGTGATGGATCACATCAGCAATGTGGGAGTGCGGCAGCAACACAACATCATGACCGGCGGTGGGGTGGCGCATCCCGGTGATCTGACGCTGATTGGCAACTGCGGTGCATCGGTGCGCAACATCGAGGACGGGAACACCAATCGGCAGGTGGCCGCGCTAGCTGCCCATCGCGGCCACCACAACCCAACTGACAATGGGGGCAGCGTCTGGAGGCCATATTGA
Protein Sequence: MTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYGSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQSNNQDFGGATNRDCVPMLPDSTASDLDQHLSSLVGSTSGQMSHHSLLGASGQTSITSTVNGASAGSGATSGSAAGAGSGAGANSILVPRYHTNASNEYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSGGGGGGGGGATNGGAANGGAGSAAGAGSGGTAGTATGAGNPAMLGTNQNFPGIVNQTQHASASAYGGGVGVGVGVGVGGGHGGSAGATAAGCNGSLYPVLPASLLYSQLYTAANQSAHGFHSHTLPAHASPNSSVHGELQSVMDHISNVGVRQQHNIMTGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01553740;
90% Identity: iTF_01554459;
80% Identity: -