Zgab005403.1
Basic Information
- Insect
- Zaprionus gabonicus
- Gene Symbol
- run
- Assembly
- GCA_018903695.1
- Location
- JAEIFO010001359.1:10038467-10070412[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5e-50 2e-46 156.6 0.0 4 94 27 117 24 126 0.96 2 2 8.4e-18 3.4e-14 52.4 0.2 92 129 135 172 130 172 0.95
Sequence Information
- Coding Sequence
- ATGCACATTTCAGCTGAGCCCGTGGACACGAGTCCCTATCTGACGCCAGAGAATCTGATCGAGCGCACCGTGGATGTCCTGCTGGCCGAGCATCCCGGTGAGCTGGTGAAAACCGGCTCTCCCCACGTGGTCTGCACCACATTGCCCACGCACTGGCGCTCCAACAAGACGCTGCCCATTGCCTTCAAGGTGCTGGCACTGGGCGAGGTCATGGATGGCACCATTGTCACCATACGCGCTGGCAATGATGAGAACTTCTGCGGTGAACTGAGGAACTGCACGGCCGTCATGAAGAATCAGGTGGCCAAGTTTAATGATCTGCGCTTTGTGGGACGCAGCGGACGAGAGACGCAGACGGAGTCGGAGACGGAGACGGAGCCCGAGACCAAACGCAGCCCTTGTCAGGGCAAAAGCTTCACGCTGACTATTGTCATCTCAACGAATCCCATTCAAATCGCCACTTACACAAAAGCCATCAAGGTGACCGTGGATGGTCCCAGGGAGCCGCGTTCAAAGGTGCGTCATCAGGGCTTTCATCCGTTTGCCTTTGGACCTCAGCGCTTTGGCCCCGATCCGCTTATGGCTGGTCTACCCTTCAAGTTGCCAGGCTTCGCACATCACCTGGTGGGCATGCACAGTCACCTGCATGCGCCCGACTGGCGAGCTCACATGGCGCTGGGCGGACGTCCAGGTTTCCCCGCAGGACCCTTCTTTGCGCACCATCACGGCGCAGGCTTTCCAGCCAGCGCGGCGGCCGGAGGATTGCGTGGACTGAGCGATAACCAGCAGCAGCAGTTGGCGACAGTGGGTGCGGCGCATAGTACCACCAGCCCAGAGGGATCGCCGACGACCACGACCAGCGCCACGCTGAGTGCGTTCGTGCAGCCGACGGTGTGTGGTGCCAGCGCGGGCGGATCGCCACCGCCGCCGTCGCTGACGCTGAGCAGCATGCAGCACCACGACAATAACAACAACAACAGCAGCAGCAATATCGATGCGGGATTCGAGAGCGACAGCATCTCGGTGACGGGATCGCCGAGGAAGAGCATCAGCTCGCTGACGCACGACGAGGAGGAGCCCGATCCGGAGGCGGGACGCAGTCGCAGCCCAACGTTGCTCAGTGCCGATGCAAGCAGTGTGGCAACGCTGGCCGAACCGTTGCCTAGCAGTGGCAATGCTGCGACAGGCGGTGGCGCTGCAGGCGGAGGAGGCGCAGGAGCTGGAGGAGGCGGAGGAGGAGGAGGTGCTTTTACCTCACTCATTCAACGCAGCAAGAATCCCACAGAGCTCTTCGGCGGATTCGCTGCTGCCGGTGCGGGACACTTTGCACCCGCGGCGCACAGCTTCAACCCGGCGCTGGCGGCACAGCTCTTCCTGCAGAGTCCCCTGCTGCCGCAGTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTCATCCCCTGGGCTCAACCGATACGGATGGGGTTAATCTGATCAAGCGTTGCGTCACACTGATCACACACAATCCGCCGGATGCCGAGAATGCCAATCCAAATGCATCGCCCCCGGTCAGTTCCACACGGCGCTCGCCCTCGCCCGTGGAGACCATCGATCTGGATGACGTCAGCACCACATCGCGCTCGGCCAGCGGCTCCAGCGGCGCAGGTGGACCCATACGCACCCGCACGCCCAAGCCGACGTCGGACGTGTGGCGCCCCTACTAG
- Protein Sequence
- MHISAEPVDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRETQTESETETEPETKRSPCQGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALGGRPGFPAGPFFAHHHGAGFPASAAAGGLRGLSDNQQQQLATVGAAHSTTSPEGSPTTTTSATLSAFVQPTVCGASAGGSPPPPSLTLSSMQHHDNNNNNSSSNIDAGFESDSISVTGSPRKSISSLTHDEEEPDPEAGRSRSPTLLSADASSVATLAEPLPSSGNAATGGGAAGGGGAGAGGGGGGGGAFTSLIQRSKNPTELFGGFAAAGAGHFAPAAHSFNPALAAQLFLQSPLLPQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHPLGSTDTDGVNLIKRCVTLITHNPPDAENANPNASPPVSSTRRSPSPVETIDLDDVSTTSRSASGSSGAGGPIRTRTPKPTSDVWRPY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01558806;
- 90% Identity
- iTF_01550054;
- 80% Identity
- -