Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00016 0.015 16.8 3.7 1 23 107 129 107 129 0.99

2 5 4.6e-05 0.0044 18.5 7.8 1 23 135 157 135 157 0.98

3 5 3.3e-07 3.1e-05 25.3 2.1 1 23 163 185 163 185 0.98

4 5 0.00025 0.024 16.2 0.0 1 23 191 213 191 213 0.96

5 5 7.3 6.9e+02 2.2 0.9 6 21 223 238 221 239 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00016	0.015	16.8	3.7	1	23	107	129	107	129	0.99
2	5	4.6e-05	0.0044	18.5	7.8	1	23	135	157	135	157	0.98
3	5	3.3e-07	3.1e-05	25.3	2.1	1	23	163	185	163	185	0.98
4	5	0.00025	0.024	16.2	0.0	1	23	191	213	191	213	0.96
5	5	7.3	6.9e+02	2.2	0.9	6	21	223	238	221	239	0.87

Coding Sequence: ATGTGTATTTTGTTATCAGGTGTATCAGTGAGGTCGCTGTCAAGCATGCGGCAGGAGTCATTGCCGATGTTGGCGGAGCGGCTGCTGGCGACGCGAGCGGCGGCGCTGGTGGCAGGGCTGCCAGCTGAGCTCTACTCGGGCGCGCTGCTTGCCGCGTGGCCACCCTCCCCGCCCGCACCACTGCTGCCGCCGCCAGAGACGGAGCGTGCTCGCAAGCGACGCCGCACACCCAAGCTGGATGACGCTACTGCGCCCCCGTCGCCCCCCTCCTCGACTGGCTCCTcacctggagctaccgaagcgccgcgcgacaagctcttcacctgcaaggtttgctctcgctcctttggctacaaacacgtgctgcagaaccacgagcgcacgcacaccggcgagaaacctttcgagtgcggagagtgccacaagcggttcacgcgcgaccaccaccttaaaacacatctccgactgcacacgggcgagaagccgtacagttgtcctcactgtccgcgccacttcgtgcaggtcgccaacctacgccgacacctgcgcgtgcacaccggtgagcgaccgtacgcctgcgctcggtgtcctgcgcgtttttcagattcaaaccagttgaaggcgcacgcactggtacacgaaggcgacgcaccattcgcatgtcGTTGTGGAGCGCGGTTCCGTCGGCGGCAGGCTGCGGCACTGCACCGCTGCACGGGCACCCCAGGCGGCTGCACCCCGGACACGCCTAGCCCGCCCGTCGTCCCCGCAGGACCGGACTGGCGCTGGGATGAGTGGCCCGAGCAGACGGAGCCGGAGGACCTGTCGCTGCCGCGGCGGCCGGCCACGCCGGACTCGCCCGCCGACCTGCGCATGCACGCCGCGTAG
Protein Sequence: MCILLSGVSVRSLSSMRQESLPMLAERLLATRAAALVAGLPAELYSGALLAAWPPSPPAPLLPPPETERARKRRRTPKLDDATAPPSPPSSTGSSPGATEAPRDKLFTCKVCSRSFGYKHVLQNHERTHTGEKPFECGECHKRFTRDHHLKTHLRLHTGEKPYSCPHCPRHFVQVANLRRHLRVHTGERPYACARCPARFSDSNQLKAHALVHEGDAPFACRCGARFRRRQAAALHRCTGTPGGCTPDTPSPPVVPAGPDWRWDEWPEQTEPEDLSLPRRPATPDSPADLRMHAA

Sequence clustering based on sequence similarity using MMseqs2