Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.55 37 5.5 0.5 2 19 156 173 155 174 0.94

2 6 1.6e-05 0.0011 19.8 0.3 1 23 198 220 198 220 0.95

3 6 0.00094 0.063 14.2 0.3 1 23 226 248 226 248 0.99

4 6 2.4e-07 1.6e-05 25.5 1.4 1 23 254 277 254 277 0.97

5 6 2.5e-05 0.0017 19.2 3.8 1 23 283 306 283 306 0.96

6 6 0.024 1.6 9.8 0.9 2 23 313 335 312 335 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.55	37	5.5	0.5	2	19	156	173	155	174	0.94
2	6	1.6e-05	0.0011	19.8	0.3	1	23	198	220	198	220	0.95
3	6	0.00094	0.063	14.2	0.3	1	23	226	248	226	248	0.99
4	6	2.4e-07	1.6e-05	25.5	1.4	1	23	254	277	254	277	0.97
5	6	2.5e-05	0.0017	19.2	3.8	1	23	283	306	283	306	0.96
6	6	0.024	1.6	9.8	0.9	2	23	313	335	312	335	0.91

Coding Sequence: ATGGCGTCACTTGTGTTGTTGAAATCCATGTTACTTACAAAGGCTCTGCAGAGAAATAGAAAGAAGAAGAAGGCCAATAACAAACCAATTTTCAGAATAATCAAACGCAAGGCTCACATTACCAAGTGCCGGATCTGCTATGAAGACCAAGCGGATATTCCAATCTTTGAGCAATACCCAGAGCAAAACCTGGCTGATGAAATACACAAATTTTCAAATGTTTTGATCACAGAATCAGACAAGTACTCAAAGTACATGTGTCAAAACTGCCTAGATTTATTAAATGGATGCATTTTATTCCGAGACTTGTGCCAGAAGACTGATAAAGCATTCATAGAAGCTTCTAAAGTAATTGTGAAACCTGAATACAATTCAGACTCAAACAATGACTTTGGCAATCTCAGTGAAGGTTCTGGCTCTTACTATATTCCATCTCCGGCCTTCTCTGACTCCTCACAACTTTGGAGTTGCTCTTCTTGCAATCAAGACTTCTATGATCTGGAGTCCTACAACAGTCACTTTCCCTGTTCCAACTCATCACAGGATGACATTCCACTAGTAATAACATCAGGGCCAAGAAAGAAGAAAGTATTCCTATGCGAAACTTGTGGCAAGACTGCATCTACTAAAGCAAGTTTATTGGTTCATATGAGTACGCACGACAACGTGTTCCCGTACAAATGTGACGTGTGCCCATACCAGGGGCGCACGATCGACCTGCTGCGAGTCCACAAGCGCTCCCACCTCACAGACAAGCCGTACAAATGCACGCAATGCCCGAAAGCCACTACGACAGCCAGCAACTTAGCCAAACACATGCGGCATGTACATAGCACGACACGGCCATTCAAGTGCACATACTGCGAGAAGTTGTTCTCTTACCAGCACGACATGAAGCGCCACATCAGAGACATCCACCTAAGGCAGGGCACTGTCGAGTGCGACATCTGCTACAAGAAGTTTAATACAAAAAAAATCCTACAAGGTCATCGATTCAAGATCCATAAGATAAAAGGCGAGAGATCTGGAAGACTGCCCTCATACCTTCTGTGTCAAATGGAAGAGCAAACTCACACCTACGAATAG
Protein Sequence: MASLVLLKSMLLTKALQRNRKKKKANNKPIFRIIKRKAHITKCRICYEDQADIPIFEQYPEQNLADEIHKFSNVLITESDKYSKYMCQNCLDLLNGCILFRDLCQKTDKAFIEASKVIVKPEYNSDSNNDFGNLSEGSGSYYIPSPAFSDSSQLWSCSSCNQDFYDLESYNSHFPCSNSSQDDIPLVITSGPRKKKVFLCETCGKTASTKASLLVHMSTHDNVFPYKCDVCPYQGRTIDLLRVHKRSHLTDKPYKCTQCPKATTTASNLAKHMRHVHSTTRPFKCTYCEKLFSYQHDMKRHIRDIHLRQGTVECDICYKKFNTKKILQGHRFKIHKIKGERSGRLPSYLLCQMEEQTHTYE

Sequence clustering based on sequence similarity using MMseqs2