Basic Information

Gene Symbol
-
Assembly
GCA_947311075.1
Location
OX371256.1:7803950-7814941[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.51 34 5.6 4.3 1 23 224 246 224 246 0.95
2 18 9.6 6.4e+02 1.6 0.2 2 23 272 294 271 294 0.88
3 18 0.00042 0.028 15.3 0.1 1 23 315 337 315 337 0.98
4 18 0.00087 0.058 14.3 3.7 1 23 341 363 341 363 0.96
5 18 0.25 17 6.6 0.4 1 23 368 391 368 391 0.89
6 18 0.0022 0.15 13.0 2.0 1 23 427 450 427 450 0.98
7 18 0.00068 0.045 14.7 0.7 3 23 458 478 457 478 0.98
8 18 0.16 11 7.2 0.0 1 17 484 500 484 501 0.91
9 18 2.1 1.4e+02 3.7 1.6 1 23 548 570 548 570 0.95
10 18 6.9 4.7e+02 2.1 0.9 2 23 596 618 595 618 0.89
11 18 1.7 1.2e+02 4.0 1.7 2 23 638 659 637 659 0.94
12 18 8.2e-06 0.00055 20.7 2.7 1 23 663 685 663 685 0.98
13 18 2.4 1.6e+02 3.5 3.2 1 19 690 708 690 708 0.87
14 18 0.039 2.6 9.2 1.3 2 23 721 743 721 743 0.94
15 18 2.8e-05 0.0019 19.0 0.6 1 23 750 773 750 773 0.97
16 18 7.3 4.9e+02 2.0 3.3 1 23 779 801 779 801 0.92
17 18 1.3e-06 8.7e-05 23.2 0.6 1 23 807 829 807 829 0.97
18 18 1.4e-06 9.7e-05 23.1 1.7 1 22 835 856 835 856 0.96

Sequence Information

Coding Sequence
ATGAATTCGATGGGTGAATCGTCGCTGTGGCAGCCGCACGTATGCCAGTGCTGCCTTATGCAAGGCTGTTACAAGGAATTGACGTCTGAGTACTTTTACATGGGCGAGAAAGAAATCTACGAAGAGATGCTCTCGGACGTCTTCAATATAACTATCGCATCAGAGCAGCAAGAACGCCGAATCTGCGAGGCGTGCATACAGAAGCTCCGTGACGGATGCAGCTTCAAGCGCCAAGTTTTGCGCAGTCAACAGACACTCCTGCAGAGAGTTCCAGATGGACGTGATAAGGCAGAAACAGAGACTTTCGCATTGGAAGTCAAGATTGAACCAGAATTTCCTGTCGCTGACGGAAACGTTGATGACGATGGTGTCTACATGGACTCATCGCCCGACGACGGCGTGAAGCTGGAAGTGTCGGTATTGCCAGTAGTCAGGCGTCCTACGGCCGATGGCGATCCACCGCGGAAAGGTCGCGATAAGAAGACTAAAGGAATGAAACGGGCAAGCGAAGTAAAACCAGAACAGACCCAGAGGCCACCTGTTGACCAGATAGCAAAGAAACCGCCCAGAACCCAAGAGCAATTCCACCGGGAGAAAAACATGAAGTTAGACACGTTACACTTAATGCAAAACTCGAACTTATGCGCGTTCAAATGGCACACGAACAAGTACCAATGTTTCTGCTGCAAGAGCACCTTCACGGACATTGAGAGTCTGAAAAGGCACACTGAGCAACACGCCTGGACTGAGACTCAGCGGCTGATGTTAAAAAATAACGCGGTACAATATCACAAGGTCGAAATCACCGACCTCACTTGCAAACTGTGCTCCGAAGCGCAAGCGAACATCCGCGCGCTGAAACAGCACCTCACGCTGAATCACAAGATCGCGTTCAGAGAAGAAAAAGACTTGCTCATACCCTTCGTAATTAAAAAGGACACGTTCCAATGCGCGGAGTGTCAGAAGACGTTCGTCGCGTTCCCGAGCCTGAACATACACATGAACGGACACTTCCCGAACCACATTTGCGATACTTGCGGCGCCTCCTTCATACACGACTCTAACCTGCGCGAGCACCTCCACAGGCACGAGAACAAGACGTACGCTTGCGACAAGTGTAACACGGAGTTCGATAGTCTTTACAAGAAGCAACTTCACGAGGCTTCAGTGCACAAGACCAACGGCAACAGACTATGTCCGCACTGTCCCGAAAAATTCCACTGCCACTACAACCGACTACTCCATCTGATCAAGTTCCACGGTTACAAGAAGCCGGAGTTCAAATGCCTGTCGTGCGATCGCGTGTTCCTGCGTCAGTACTTGTTGAATTCCCACGTGCGCAAGTTTCACATGAAAGAGAAGAACCACGGCTGTGAACTGTGCCAGGCTAAGTTCTTCACGAAGTATGATTTGAAGCAGCACATGGGCACGCACGGAGGAAGCTCCACTCATGTGTGCGTCGTTTGCGGGAAGGGCTACGCGCGTAACCCTCAGCTAAACCTCAACGGGAAACCGCAGGGCTCCGAGAAAAGCACTAACGCCGAACTAGACACCAAGAAAAAAGAAGCACACATGAAAACGACCACTCTAGACCTTGTCCTGAACTCCAATCTGACTCTATTCGACTGGTGCAAGAACAAATACAGATGCTTCTTCTGCAAGGAAATGTTCCTGGAAACAGCGTTGCTCAAGGAACACTCAAAATCTCACGGCGAGGACGAGGTGCAGCTGAAAATCTACAAATACAACGTCAAGAATTACTATAGAGCCGAAATAACGAATCTACAGTGCAAGCACTGCATGACATTGGCTGAGAATCTCGTAGAATTAACACAACACTTGTCCACAAGCCACAATATCACTTTCAAGGCACAAGACTCCCTTCTAATGCCTTACAAACTGACAGACTTAACTTGTCAGCTTTGTAGGCAAGAGTTTCAGTCGTTCGTAGTGTTAGATCATCACATGACTTCCCACTACAGCAAATACGTGTGCGATACTTGCGGCAAGGGATTCCGGCAGAAGTACTGCCTCAGATCACATTTGGTCACGCACGTGAAGAAGCTGTTCAAGTGTAAAACGTGTAACATAAATTTTGATAATTACTACAGGAAAAGAAAACACGACGTGTCTGAGCACGACGTCTCTGATAAGTTCAACTCGTGCCCGCACTGCCCCGAGAAGTTCATACACTACGCCGGGCGTCTCAAGCATTTAATAAAGGTGCACGGTTACAAAAAACCCGAGTTCAAATGCACCAACTGTGATAAAGTTTATATGAACAACGCGTTGTTGCGATCTCACGTGCGAAACGTTCACTTGCAAGAACGCAACTTCGAGTGTAATATATGTCAAAATAAATATCTGTGGAAGTGCGAGTTGACTGATCACATGAAATCCCATATACAAGCCAGAGATTTCGTCTGTACGTATTGCGGTAAAGGGTTCTATAGGCGGAGAAACTTGAACGAGCATCTCGCGATACACGTGGAGGAGTTCCGGCACACTTGTACAGTCTGCGGCAAGTCTTTTGCTCAGAAATATAATATGAAAATGCATATGCGGAGGTGTCAAGACAGTAAGAAGAAATGA
Protein Sequence
MNSMGESSLWQPHVCQCCLMQGCYKELTSEYFYMGEKEIYEEMLSDVFNITIASEQQERRICEACIQKLRDGCSFKRQVLRSQQTLLQRVPDGRDKAETETFALEVKIEPEFPVADGNVDDDGVYMDSSPDDGVKLEVSVLPVVRRPTADGDPPRKGRDKKTKGMKRASEVKPEQTQRPPVDQIAKKPPRTQEQFHREKNMKLDTLHLMQNSNLCAFKWHTNKYQCFCCKSTFTDIESLKRHTEQHAWTETQRLMLKNNAVQYHKVEITDLTCKLCSEAQANIRALKQHLTLNHKIAFREEKDLLIPFVIKKDTFQCAECQKTFVAFPSLNIHMNGHFPNHICDTCGASFIHDSNLREHLHRHENKTYACDKCNTEFDSLYKKQLHEASVHKTNGNRLCPHCPEKFHCHYNRLLHLIKFHGYKKPEFKCLSCDRVFLRQYLLNSHVRKFHMKEKNHGCELCQAKFFTKYDLKQHMGTHGGSSTHVCVVCGKGYARNPQLNLNGKPQGSEKSTNAELDTKKKEAHMKTTTLDLVLNSNLTLFDWCKNKYRCFFCKEMFLETALLKEHSKSHGEDEVQLKIYKYNVKNYYRAEITNLQCKHCMTLAENLVELTQHLSTSHNITFKAQDSLLMPYKLTDLTCQLCRQEFQSFVVLDHHMTSHYSKYVCDTCGKGFRQKYCLRSHLVTHVKKLFKCKTCNINFDNYYRKRKHDVSEHDVSDKFNSCPHCPEKFIHYAGRLKHLIKVHGYKKPEFKCTNCDKVYMNNALLRSHVRNVHLQERNFECNICQNKYLWKCELTDHMKSHIQARDFVCTYCGKGFYRRRNLNEHLAIHVEEFRHTCTVCGKSFAQKYNMKMHMRRCQDSKKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01546916;
90% Identity
iTF_01546916;
80% Identity
-