Basic Information

Gene Symbol
Zbtb41
Assembly
GCA_947310995.1
Location
OX371296.1:1822192-1840480[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.31 22 6.3 1.0 1 23 188 212 188 212 0.90
2 13 0.00011 0.0075 17.2 1.5 1 23 219 241 219 241 0.98
3 13 0.6 43 5.4 0.3 1 20 281 300 281 302 0.92
4 13 0.012 0.88 10.7 4.8 1 20 306 325 306 328 0.94
5 13 9.5e-05 0.0068 17.3 2.6 2 22 337 357 336 361 0.92
6 13 0.86 62 4.9 4.2 1 23 369 392 369 392 0.86
7 13 0.00045 0.032 15.2 2.0 1 19 398 416 398 421 0.91
8 13 3.9e-06 0.00028 21.7 2.1 2 23 434 455 433 455 0.97
9 13 0.0012 0.084 13.9 0.1 1 23 461 484 461 484 0.93
10 13 3e-06 0.00022 22.1 2.8 1 23 499 522 499 522 0.96
11 13 3.7e-05 0.0026 18.6 1.4 1 23 528 551 528 551 0.92
12 13 9.5e-07 6.8e-05 23.6 2.7 1 23 559 581 559 581 0.99
13 13 0.067 4.8 8.4 4.3 1 23 589 612 589 612 0.96

Sequence Information

Coding Sequence
ATGGGCTTAATCACCACGCGTGCCCACCGCGGATTGGCGATTTCTAGCGCTGAGGTCCCACCGTCATCGGAGACCAGCCTTTGCGTCACAGAACTGGAGCTGGTGAACATAGCTCCTTTCCCTTTGAAGCCGGAGCCCGAACAGAGAAGTGACTTGCTGGCTAAGAACGAGCCGCAAATAGCGCCCGATCTTGGTTACGAGCTTCCGCTTTCGAAAGATGAAATCAAACTCGAAGGTGATTTTTTAGACGATATCGGTTCTGACGGAGACCTACCGGCTGAGGATGAGGATGAAAAAGAAGCGTTAAAAAAGGAGAAGATCCCAGAAAAGGAGAAAGTCTCGCATGAAGCAGCGCGGAAGAAAGTCAGGAAGGAAGTTGCCGCCAAGAAAAAGGTCGTCAAGAAGAGGAGCTCCAAGCTCGCAAGAACCAGAAGCGAGAGAGAGAAACCCAAACGGAGCGCCAAGAAGCAGAAAGACCTCTGCTGGTCGGTCCGGTGGGTCACCAACGAGAAGGCGACCAGCTGGTACGAGGAGGAGCGCGCCGGCGAGACGCCCGGCAACTTCGTCTGCGCGCAGTGCAAGCGGACCACCTTCGCCACCGAAGAGGAGCTCGTGAGGCACCATACTGAACAGCACGACGAATTAGTCGGCGAGTACCAGTGCAATTTATGCAAATATAGATACGGGACGCTGTCCACACTCCGGCAGCACATCGAGCGTCACTTCATAGAGTACTATTGCCGGGAATGCGAATTCCAGGCGAGGGCTATCAAAGCTATCAAGGACCACTGTAGCGAGGCGCACGAAGTCCGCGTCAGAAGGCGGACCAAGCCCACCTCTTACTTGTGTAAAAGGTGTAAGGATACTTTTCCGACCTTCGCCTTGCTCCGCGAGCACCGCCTGGACTGCAGTACGTACAAATGTGCCAAGTGTGAGAAGACTTTTAAGAACAAGTGCACTTATTTCGACCACCTGCCGCTGCATAAGGAAGGAGCTAAGGAGAAGCTCTATTGCCATATCTGCGACAAACAGTTCACGAGCGCCAGTTGGTTCAAGACACACTTCCGTACCAGTTTGAAGCATGTTTCGAGGGACACCTTCCAACACGAGTGCCCCCACTGTCACATGCGCTTCCACATCGCCCAGCGCCTGAAAGAGCACGTCGCCGCTAAGCATCTCAACAGAGGACTCTACGCCTGCGATCTGTGCCCCAAGAGTTTCACCGTTAACAAGAGTCTGAAGAAGCACTGTGCGCGCGTCCACAACATCGGGACCATCAGCGAGCCAGCGCGAGACAAAGTGTGCGAGCACTGCGGGAAGGCTTTCACCTCCACAACGTTCCTGAATGACCATATGCGCATGCACACGGGCGAGAAGCCGTTCAAGTGCACCCTGTGCCCGGCCGTGTTCGCGCAAAACGGCACCCTGTATATTCACACGCTCGGCGTTCACAAGAAGAAGCTGCGCAAAGACGGACTGACCGACTCTCCCACATACCAGTGTGAGGAATGCGGCAAGGAGTTCTCGTCCAACAGCCAGATGCGGACGCATCACAAGCTGACTCATCTCAAACAGAGTAACTTCTCCTGCGAAGCTTGCAACAAGGTGTTCTCGTCTTCAACTCACCTCAAGAACCATTTGGCGGGGCGGCACGGCGTCCTCTCCAGTGACACCTTCAAGTGTGACACTTGCGGGAAGAGATACAACACAAACACGGCCTTAAAAACCCACATGAAGCGACACGGGGGTCTCGACACGAGCATGCATAAATGCCGAGTTTGCGACGCCGAGTTCAAGCATCTCACAGCCTTGCATCTGCACTTCAAGATAATACACTTGAAGCTGAAGAAAGGCGACAAAGTTAGCTTGAAGAACATCGGAAACCCGGATAAGGAGCTTATCATAAACGGAGAACCGCAGAGAACGCTGTTGGAGAACTTGAGTTTAAGTTTGAACAGCTCTTAG
Protein Sequence
MGLITTRAHRGLAISSAEVPPSSETSLCVTELELVNIAPFPLKPEPEQRSDLLAKNEPQIAPDLGYELPLSKDEIKLEGDFLDDIGSDGDLPAEDEDEKEALKKEKIPEKEKVSHEAARKKVRKEVAAKKKVVKKRSSKLARTRSEREKPKRSAKKQKDLCWSVRWVTNEKATSWYEEERAGETPGNFVCAQCKRTTFATEEELVRHHTEQHDELVGEYQCNLCKYRYGTLSTLRQHIERHFIEYYCRECEFQARAIKAIKDHCSEAHEVRVRRRTKPTSYLCKRCKDTFPTFALLREHRLDCSTYKCAKCEKTFKNKCTYFDHLPLHKEGAKEKLYCHICDKQFTSASWFKTHFRTSLKHVSRDTFQHECPHCHMRFHIAQRLKEHVAAKHLNRGLYACDLCPKSFTVNKSLKKHCARVHNIGTISEPARDKVCEHCGKAFTSTTFLNDHMRMHTGEKPFKCTLCPAVFAQNGTLYIHTLGVHKKKLRKDGLTDSPTYQCEECGKEFSSNSQMRTHHKLTHLKQSNFSCEACNKVFSSSTHLKNHLAGRHGVLSSDTFKCDTCGKRYNTNTALKTHMKRHGGLDTSMHKCRVCDAEFKHLTALHLHFKIIHLKLKKGDKVSLKNIGNPDKELIINGEPQRTLLENLSLSLNSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01545123; iTF_01544216;
90% Identity
iTF_01544216;
80% Identity
-