Basic Information

Gene Symbol
-
Assembly
GCA_947310995.1
Location
OX371295.1:7587689-7590789[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.022 1.6 9.9 1.1 1 23 121 144 121 144 0.94
2 19 1.4 1e+02 4.2 2.6 1 23 212 234 212 234 0.94
3 19 0.00041 0.029 15.3 1.0 1 23 238 260 238 260 0.98
4 19 0.054 3.8 8.7 1.7 1 23 267 290 267 290 0.91
5 19 0.75 53 5.1 4.6 1 19 296 314 296 319 0.89
6 19 9.8e-06 0.0007 20.4 3.6 1 23 327 349 327 350 0.96
7 19 0.00035 0.025 15.5 0.3 1 23 356 378 356 378 0.98
8 19 3.2e-06 0.00023 22.0 1.9 1 23 385 407 385 407 0.98
9 19 0.069 4.9 8.3 0.1 1 17 413 429 413 430 0.91
10 19 0.0013 0.096 13.7 1.8 2 23 466 488 465 488 0.89
11 19 4.4 3.1e+02 2.7 0.1 2 23 514 536 513 536 0.90
12 19 1.3 93 4.3 5.5 1 23 556 578 556 578 0.97
13 19 0.0067 0.48 11.5 0.3 1 23 582 604 582 604 0.98
14 19 7.4 5.3e+02 1.9 2.8 1 12 611 622 611 634 0.77
15 19 1.2 88 4.4 2.9 1 19 641 659 641 664 0.90
16 19 1.8e-05 0.0013 19.7 2.6 1 23 672 695 672 695 0.98
17 19 0.0058 0.42 11.7 0.5 1 23 701 723 701 723 0.98
18 19 5.4e-07 3.9e-05 24.4 0.9 1 23 730 752 730 752 0.98
19 19 0.0019 0.13 13.3 4.1 1 23 757 780 757 780 0.95

Sequence Information

Coding Sequence
ATGGACGTTGGACCTCCTAGTTTTATCACTGGTACACCCAACATTTGGCGATCACCGAGCCTTTGCATATCAGCTAAGAAACTGGTGAGACCTGTAAAGGGGGTACCTGTTTTACAAATTCCCATCAATCCGGCAAAGCCCAATGTAAGAACGATTACACGGCTAGTACGTAAAAAACCAGTTACGGCTACCAAAGGAAAACCCAAAGACAAACCGGAAGGCGAAACAGAAGACTCCACAAAGAAGCCGAAATCAGGCCTAAAGATTGACCGCCACCAAGGACGAAAATTCCGTGAAACAATACTGAGTCTGTGCCAACATTCGAATGCCAATATCATAAAGAAGATAGACCACGGTGGGTTCCACTGCTGCGTTTGCCCTGAAAAGTTCCCAGAGGCAGCCCAGTTAAAGGAACACTTCATTAGCATCCACAATAGGCAAGAAAAACTAAAAGAAATAGACTTTGCTGTCCTGAGCTGCTCGGCCAAAGTCGACGTCACGGGGCTCACCTGCGCACTGTGCCATCAAGAAGTTGACACACTGGAATTGATGCTCGATCACTTGTGTTTCGAACACCAGAAAACTGTGCACGAAGGATGCAACATCCTGCCGTTCAAATTTGACAAGCCAGGTTATTGCTGTGTGGCCTGCGAAGCCAAATTTGGCACATTCAAGTCGCTCCTGAGTCATATGCACGCACATTACAACAACTATATCTGCGACATCTGCCAATCGGGTTTCTATAATAAGGGCAGTATGCGGTCCCATCGGAGGACACACTCCTCTGTAAATGACACTTTCGCTTGCACGCATTGCTCCAAAACTTTCGTCACCGACATCAGCCGCGTGAACCACGAGAAGAGAGTCCACTTGGGGCTGAAACCCTACACATGCCACCATTGTCCGGAAAAGTTCCAGGATTACTACGAACGCAACGATCACTGCATAGAAGTCCACGGGTTGAAGGACATGGGCAACTTTCAGTGCCAAGCTTGCGACAAGAGATTTAAGCGCTCTTATGCGCTGAGAGAGCATGTGCGTAGACATCACCTCATGGAGCGGCGGTACGACTGCAACATCTGCGAGAAAAGATTCTGGAGCGCGCAGGAGCTGAATGACCATATGCTGAAGCACACGCGCGGCCCGGCCGAGTTCATCTGCGAGAAGTGCAATAAAGGATTCAGCAGGAAGAGAGTTTTGCAAAAGCACATGCAGTCCCATTACCCGGTGGCGCAATACGCCTGCGAAGCTTGCGAAAAAACGTTCACACAGAAGGCTGGTCTTACCACAGTAATAAAAAACCGCTACAATGCCAAGAGATATCGTGAAACACTGACAAGTCTATTACTATTCTCGAATGCCAATCTCATCAAGAAGATAGATCACGGCGGATGCCACTGCGTGGTTTGTCCAAAGAAGTTCTCTGATGCTGCCGATTTGAAGGAACACTTCAACGAACTTCACTCCCGCCCAGAGGCTCTTAAAAAAGTCAACTTCAAACATCTGCTCCACAAGGCTAAGGTTGACATTACGACGCTCGTCTGCACACTGTGCTTTGAGAAATTCGATGGCGTGGAACTGATCCTTGAGCACTTGCGCTTAGAGCACGAGAAAATGACGTACGACGGCTGCAATATCCTACCATTCACGTTCGACAATCCGGGCTACTGCTGCGTATTCTGCGAAAGCAACTTCGGGACGTTCAAATCATTGCTGAGTCACATGCACACCCATTACAATAACTACATCTGCGATATTTGCGAGACCGGCTTCTTCAGCAAACAAGCCATGTTGGCTCACAAGAAATCTCACACCGCCATTAAAAAGGCGTTCGCTTGCAAGCATTGCGAGCAGAAATTCGATACCGATTTGTGTCGTGTGCTTCACGAAAAGAGAATGCATCTAGGGATGAAGCCTTACTATACATGCTACTACTGCCCGGAAAAGTTCCAGGATTACTACCAACGGAATGACCACTGCATAGAAATACACGGCTTAAAGGACATGGGCAACTTTCAGTGTCGGGCCTGCGACAAGAGGTTTCGTCGTTCGTACATGTTGAGGCAGCACGTGCGTAAAGAGCATCTCATGGAGAAGATATACCCGTGCGGTGTGTGCGGAAAGAAAATGAAGAGTTCACAGGAGATCCACGACCACATGATGATGCACAAACGCGAGCCGACTGAATTTGTTTGCGGAGAGTGTGAAAAGACCTTCAACAGGAAGAGGACGTTGCAAATTCACATGCTGACACACTTTCCACCTCAACACGCGTGCGAGTTTTGCAACAAAGTGTTCTCTCGGAAGTCTGGGTTTACGTTTCACTTGAGGAAACAGCACGGTGTGACTATCATGTCATCTTTTTAA
Protein Sequence
MDVGPPSFITGTPNIWRSPSLCISAKKLVRPVKGVPVLQIPINPAKPNVRTITRLVRKKPVTATKGKPKDKPEGETEDSTKKPKSGLKIDRHQGRKFRETILSLCQHSNANIIKKIDHGGFHCCVCPEKFPEAAQLKEHFISIHNRQEKLKEIDFAVLSCSAKVDVTGLTCALCHQEVDTLELMLDHLCFEHQKTVHEGCNILPFKFDKPGYCCVACEAKFGTFKSLLSHMHAHYNNYICDICQSGFYNKGSMRSHRRTHSSVNDTFACTHCSKTFVTDISRVNHEKRVHLGLKPYTCHHCPEKFQDYYERNDHCIEVHGLKDMGNFQCQACDKRFKRSYALREHVRRHHLMERRYDCNICEKRFWSAQELNDHMLKHTRGPAEFICEKCNKGFSRKRVLQKHMQSHYPVAQYACEACEKTFTQKAGLTTVIKNRYNAKRYRETLTSLLLFSNANLIKKIDHGGCHCVVCPKKFSDAADLKEHFNELHSRPEALKKVNFKHLLHKAKVDITTLVCTLCFEKFDGVELILEHLRLEHEKMTYDGCNILPFTFDNPGYCCVFCESNFGTFKSLLSHMHTHYNNYICDICETGFFSKQAMLAHKKSHTAIKKAFACKHCEQKFDTDLCRVLHEKRMHLGMKPYYTCYYCPEKFQDYYQRNDHCIEIHGLKDMGNFQCRACDKRFRRSYMLRQHVRKEHLMEKIYPCGVCGKKMKSSQEIHDHMMMHKREPTEFVCGECEKTFNRKRTLQIHMLTHFPPQHACEFCNKVFSRKSGFTFHLRKQHGVTIMSSF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-