Basic Information

Gene Symbol
topi
Assembly
GCA_905220385.1
Location
LR999958.1:13144528-13148786[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 3.3e-05 0.004 18.1 2.9 1 23 186 208 186 208 0.97
2 10 0.34 40 5.5 3.2 2 23 236 257 235 257 0.90
3 10 0.37 44 5.4 0.1 2 19 312 329 311 331 0.94
4 10 0.02 2.5 9.3 1.0 1 22 379 400 379 403 0.90
5 10 0.0031 0.37 11.9 0.0 2 23 418 440 417 440 0.90
6 10 4.1e-07 4.9e-05 24.1 2.0 1 23 455 477 455 477 0.95
7 10 0.0017 0.21 12.7 0.9 1 23 483 508 483 508 0.95
8 10 0.66 79 4.6 1.6 1 23 514 536 514 536 0.88
9 10 5.2e-07 6.2e-05 23.8 0.2 3 23 544 564 542 564 0.98
10 10 0.022 2.7 9.2 3.1 3 23 572 593 570 593 0.95

Sequence Information

Coding Sequence
ATGAAGGATgtagaagaaataaaattcagCACAGATGCAGAGCAAGATTCACAAGAAGCTGATGGAACTATCAACTCAGATGTTCTCGATTTGGGCGCATTGCCAGTTGAACAGCCGGTTCATAAAGAACCTCTGCAACAGCAGGAAGCTCCGCGTCCAAGTCCTGAGCAACCCCAGGAAGAATTGAATGTACCTGAGAGAGAAGACGCTGAAGTGGCACATCAAATGCCCCAAGATCaacatttatttcaatatttcgATCCTTCACTCTTTTTCCCACAGAACCATTTACGTATTGTCGAATGCGCCAACTGCAATTGCATCTTTGATGCCGGTTCGTTTCATCAGCATGTGTGTGATTATGGCGAGGACAATAATCTGATTATTCCCGAACCTATGGAACAGTCGATGACGTCCTTTCAGGCAGGTCCCATTGAACCGCCCTGCATGCGATTGCTTCGTGAGAATCAAATTCGCATCCGTCGCTTTCTCAAAGACGAACTGAAGTACGATTTGAATGCTGGGAATTCAAACACTAAGAAGCAAGACGGTCCACATGAATGCACTTTGTGCGAAAGAAAGTTTGTCCATGCATCAGGTTTATCGCGTCACATGGAGAAACACGCACTGGATTTGATACCCACTACGACTTCGACCAATGCAAGCAATGGCTATCCATCGATTAACGGTTTAAAGGTAGTTATCAAATGTACGATCTGCGGACGCATCTTTTTCGAGCCGAAAACTGCCTGTGAGCATTTTTGCTTGCATTTCCCGGGAACACATGAAGACGAACGAGAATTCGGTGAGACCGGTGAGTTTCCATACGAGAACTATCTCGATGACGCTCTAAATTTCCTGAAAATTGAGTCCAAAAAGCCCGACAACAAACCCACCTCCTACCTCAAGATGGTAATTTTAAGTTGTGTATTGCAGTGCGAGTTCTGTGATCTCCTATTTTCGGAGGTTTCATATTTGTTCACACACTCAGCGTGCCACCAGCCACAGAGACCATTTGAGTGTTGCGCTTGTGAGATACGCGTCTTTACTTCGAAGGAGATTTTCATGCATTGGCAGGCAGAATGCGTTTTTGCTCGAGAAAATATGAAACGCGGTTGTTCGTCGCAGAGGTACTACGTGTGTAATGTCTGTGAGAATAAGTTCGGTTCGCTGGAGCAGCTGCATGAACACAGATACACTGCTTATCATTTTTTTCCGAGAGTCGATAAGAAAGAAGGGGTTCTGCTGATACCTTGTGAGTACTGTGATCGAGTATTTGAAACAGCAAATGACATTGTGAATCACTATGAAGAGAAACACTACAAAAAGAATAAGCGGGATCCGACGGCTAAGTATCGCCAGTATTTGTGCGATATTTGTGGAAAGACCTACACACAGTCTAGTCATTTGTGGCAGCATTTAAGATTTCACAAAGGTGTCAAGCCGTTTGCCTGCAAGGAACCCGGCTGCTCACGTCGATTCACCATTCGTCCTGATCTTAATGACCACATTCGTAAGTGCCATACTGGCGAACGGCCATATCATTGCCTAGTCTGCGGCAGACGCTTCCTAACTGGTTCAGTGTTCTATCAACATCGCTTAATTCATCGTGGCGAACGTCGTTATGGATGCGACGAGTGTGGCAAGCGATTCTATCGTGCAGATGctttgaaaaatcatcttcgCATTCACACCGGGGAAAAACCCTACGGCTGCCTGTTCTGTACGAAATGTTTCCGTCAAAGAGGCGATCGTGACAAGCACATCCGAGCAAGACACTCTAGTTTGGACGCGAATGCCCGTCTAATGATGCAAATGCGCAAGTTACAGTTGGAAGCCGCCGCTCGTGCGAATGCCTCTTCATCGACTCCAGCCGAGGACGTGCTGATGCTGGGTAACATCCCATTTCCGAAGAGCATGTTCCAACCCATCTTATCGGACATTGATGCAGGCCAGGACTGA
Protein Sequence
MKDVEEIKFSTDAEQDSQEADGTINSDVLDLGALPVEQPVHKEPLQQQEAPRPSPEQPQEELNVPEREDAEVAHQMPQDQHLFQYFDPSLFFPQNHLRIVECANCNCIFDAGSFHQHVCDYGEDNNLIIPEPMEQSMTSFQAGPIEPPCMRLLRENQIRIRRFLKDELKYDLNAGNSNTKKQDGPHECTLCERKFVHASGLSRHMEKHALDLIPTTTSTNASNGYPSINGLKVVIKCTICGRIFFEPKTACEHFCLHFPGTHEDEREFGETGEFPYENYLDDALNFLKIESKKPDNKPTSYLKMVILSCVLQCEFCDLLFSEVSYLFTHSACHQPQRPFECCACEIRVFTSKEIFMHWQAECVFARENMKRGCSSQRYYVCNVCENKFGSLEQLHEHRYTAYHFFPRVDKKEGVLLIPCEYCDRVFETANDIVNHYEEKHYKKNKRDPTAKYRQYLCDICGKTYTQSSHLWQHLRFHKGVKPFACKEPGCSRRFTIRPDLNDHIRKCHTGERPYHCLVCGRRFLTGSVFYQHRLIHRGERRYGCDECGKRFYRADALKNHLRIHTGEKPYGCLFCTKCFRQRGDRDKHIRARHSSLDANARLMMQMRKLQLEAAARANASSSTPAEDVLMLGNIPFPKSMFQPILSDIDAGQD*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00992100;
90% Identity
iTF_01541716;
80% Identity
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