Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00022 0.022 16.2 2.1 2 23 100 124 99 124 0.95

2 5 5.1e-05 0.0052 18.2 2.3 1 23 131 153 131 153 0.98

3 5 0.00012 0.013 17.0 0.3 2 23 159 180 158 180 0.97

4 5 0.00016 0.016 16.7 1.3 1 23 186 209 186 209 0.93

5 5 3.2e-05 0.0033 18.8 0.3 3 23 216 236 214 236 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00022	0.022	16.2	2.1	2	23	100	124	99	124	0.95
2	5	5.1e-05	0.0052	18.2	2.3	1	23	131	153	131	153	0.98
3	5	0.00012	0.013	17.0	0.3	2	23	159	180	158	180	0.97
4	5	0.00016	0.016	16.7	1.3	1	23	186	209	186	209	0.93
5	5	3.2e-05	0.0033	18.8	0.3	3	23	216	236	214	236	0.96

Coding Sequence: atgGAACAATCTATTAGTATACTTTGTGCTAGCAGCGATAAACATGGCAACAATGCTGATTTTGGTTCGGAAACTGATCCTTTGGAAGAAATTGGTGCAGAAAGCGCTATATCTACTAAACCAAGATTCTACAAAATGAATAGTATTGTGTTTGCTGAGTCTTTGAAAAGTATGGTTAATGAAGAAAATTCATCAAAAGATGAAACTGAAATAACAATCATAGAAAATGTAGTAATACTGAAGACTggcaagaaatataaaaaatatcagtTCAATATTGAAGACAGTTTCCCAATGAGATGTACTCAGCTCAACTGCCTCCGTACATTTCCTACAAAAACCCACCTCATATCTCACATACGTAGAGTGCACTGTGCGGACCCCAAGAGATATATCTGTGAGCAGTGTGGCCGCGGCTTCCCTGAACGTCACATGTTGAAACGACATGCCCACACGCACAGTGACGAGACCATGGAGTGTCCTGTTTGTGGTGTCAAGCTGAGGTTAAGGACTAGCCTAACAACCCATCTCCGTACCCACTCCAACCTGCGTCCTCACGAGTGTGATATCTGTAAGAAGACCTTCGCGAGGGCGTCTAGCAAAGCGACGCACGTCAAGTTTGTGCACAGAGAGGGTTTGCTGGACTGTGGCGACTGTGACGAGagATTTGCATCGCGTAAACAGTGGAGTCAACACATGAAGATCCACAGACAAAAGAAAACCTGA
Protein Sequence: MEQSISILCASSDKHGNNADFGSETDPLEEIGAESAISTKPRFYKMNSIVFAESLKSMVNEENSSKDETEITIIENVVILKTGKKYKKYQFNIEDSFPMRCTQLNCLRTFPTKTHLISHIRRVHCADPKRYICEQCGRGFPERHMLKRHAHTHSDETMECPVCGVKLRLRTSLTTHLRTHSNLRPHECDICKKTFARASSKATHVKFVHREGLLDCGDCDERFASRKQWSQHMKIHRQKKT

Sequence clustering based on sequence similarity using MMseqs2