Basic Information

Insect: Xanthostigma xanthostigma
Gene Symbol: topi
Assembly: GCA_963575645.1
Location: OY754471.1:5317476-5322950[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.0048 0.098 13.7 0.8 3 21 132 150 130 151 0.94

2 13 0.0016 0.032 15.2 6.0 1 23 175 197 175 197 0.97

3 13 0.003 0.061 14.3 0.2 1 23 203 225 203 225 0.96

4 13 0.0018 0.037 15.0 1.5 1 23 359 381 359 381 0.98

5 13 8 1.6e+02 3.5 0.2 1 20 387 406 387 408 0.89

6 13 0.028 0.58 11.2 1.8 2 21 424 443 423 447 0.88

7 13 0.88 18 6.5 0.5 1 23 780 803 780 803 0.91

8 13 0.32 6.7 7.9 1.6 1 23 807 829 807 829 0.92

9 13 6e-06 0.00012 22.8 2.5 1 23 835 857 835 857 0.98

10 13 0.14 3 9.0 0.2 1 23 863 888 863 888 0.96

11 13 0.75 15 6.8 1.8 1 23 894 916 894 916 0.85

12 13 3.2e-05 0.00067 20.5 0.4 3 23 924 944 922 944 0.97

13 13 3.5e-05 0.00072 20.4 1.8 1 23 950 973 950 973 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.0048	0.098	13.7	0.8	3	21	132	150	130	151	0.94
2	13	0.0016	0.032	15.2	6.0	1	23	175	197	175	197	0.97
3	13	0.003	0.061	14.3	0.2	1	23	203	225	203	225	0.96
4	13	0.0018	0.037	15.0	1.5	1	23	359	381	359	381	0.98
5	13	8	1.6e+02	3.5	0.2	1	20	387	406	387	408	0.89
6	13	0.028	0.58	11.2	1.8	2	21	424	443	423	447	0.88
7	13	0.88	18	6.5	0.5	1	23	780	803	780	803	0.91
8	13	0.32	6.7	7.9	1.6	1	23	807	829	807	829	0.92
9	13	6e-06	0.00012	22.8	2.5	1	23	835	857	835	857	0.98
10	13	0.14	3	9.0	0.2	1	23	863	888	863	888	0.96
11	13	0.75	15	6.8	1.8	1	23	894	916	894	916	0.85
12	13	3.2e-05	0.00067	20.5	0.4	3	23	924	944	922	944	0.97
13	13	3.5e-05	0.00072	20.4	1.8	1	23	950	973	950	973	0.98

Sequence Information

Coding Sequence: ATGGATGAAAATGCACATCTACAAGGCATTTCCTTGGTGGATGACAATCAAAGCGATATTCTTTCTCAAGCATTAGTTTCAACTGAAGAGGTGAAACTAAGCGATTCGCCCGTTCAATGGGGATATGTAATTGATACCGATTCAAAACTTAACTTAAAAATGCAATCGAGCCCTGCAACGATAACGTTAATTAAAATAGGAGGTATAGAAGATTTGAACCCGTTAAATTATACAACCCACATTGCTCCACCGTTGAATCAGATTCATCGTGTTGTGATAGatgatgaaattttaaatgatcaaTTGCCTGAAATGATAGTACCATCAAAAATTAAAGACAAATCGAAAAAGAAATACATGCCTCCTTTACCTCAAACCGAACCAGCAGTTATATGCCAAAATTGCGATGCATCATTTGccacaaaatattattaccaGCGTCATCAGTGCGAGTTCAATGCCTCCAAAGTTATGCTAAAATCAGAATTACCCAAACGTAACATAGAAAAACCAAAGACGAAACATGAATGTGATATATGCCATAAATCGTTCATGACTGAGCATAACTTAGACAGACATCGCTTATCACACGGAGAGAAAAAGCCATTCATTTGCCAAAATTGCGGAAAAGGATTTGTCCTTGAATCAAGATTAAATACGCATATAGAAAATCATTGCAAAATGACTTCAGGAGAAAAGAAACGATTTTATAGGTCAGATTTATCTGTCTGGGAATGTTGGAATTGTAAACTGCCCAATGACAAtcaagaaaataaagaaaatgatccTAAAACCACCTTTCCTCATTCAACTGCCACATCTAAACCAACCCAAGAGTCCGTTAAGATTGTTAAAATTCTAGGAGAAAATAATTATTCGACAACCACTGAAAATTTCATTCTGAACAATTTCGATGCCAATTTTGAAAAAGCAATGAGTGGTATAGATTTATTTTCACAGCCAGAACCAGGTTTTTATAAAGAAGCCGCAAGTACTAAAAATGTTCGTATTGttaacgataataataatatgaaaatcgATCATACTTTTGTTAAAATCAGAGTCGAACAATTGTTTCAATGCGAATATTGCAACCGGACCTATgccaaaaaagatattttaaaggATCATCAAAATTCACAtacagttaataaaaattatctttgtATGTTTTGTGAAGAAAGTTTTGAAAGCTACACCAATGCTATTGTCCATTGGCAACATAAATGCGACAATAAAtggaatgtattttgtttgccgAAAATTGTTGTGTGTAAATTTTGTGACAAAGGGTTTAAGTCGCACGAACTGCTTTATGCTCATAAATATAAACTACGACATTTTGTACCGAAAGTATGTAAAGATGGAAGAAATGAATCGTCGAAACAAAGTAATAGACCCGACGAGTCTGATTTCAATTCAAAGAGAATTGAAGGAACCGAACGCGGTTCGAGCGAAGTAAAAAAAGATGTTATTTATTCAACGATAAATAttagtttcgatgacaatactcGAATAAGAACACTTACTATAGATGATCTGACAAAACTGAGTCTCGATATGCCCGATAATAATAAATCTGTTGTCGATATATCGAACGGAGAGATAAATGTTTCCGATATCAACATACAAGATATTCTTATGGATTCTAATAATACATCGGTGAAGACAGATAATGGATGCGAAAATGAAAGCACAAATCAACCCATAAATGATTATGAATACAACGAGAtagataaatttttaaacgaaattGAAAGAAAGGTTTTAGATAACAAAGGTCTGTGTGATCGAGCAGcagataatgataataatatgacAAGTATAAAAATGGAATCGATAGAAATACTCGATGATATGGTCCAAGATGAAATAAATTTAGAAGAGCCTTTTAAAAAAAGGTTACGGCGTAGTTTAAGAAAATGTAATCAAACTGAAAACGTTGAAAAAGAAAACGTAGCTGAAAAAGatgaaaactttgaaaaaaataaaagaggaAGAAAAAAGAgttctgaattttttaaatttccgttACCGGATATAAACAAAAGGTTGACCCGTAACAGTTTGAAAAATCTGgtcgaaaaagaaaatattgtcaGAAACGAAAATCTCGAAGacgaaacaattgaaaaaaagaagaaacctGAAGAGACTGAGTTGACAGTTAACATAAAATTAGAACACGATGATGATAAATCCGATAAAACAGATGAAGATACTGATTCAACTACGGTGACTGTAGTTACTCCGGTGCCTTCCAAACGTGGCAGAAAaccaaaaccaaaattaaacATGGATCCACCGGTTATTAACGAATGCGCCGACGGGTTCCGATTCCAATGTGAAAAGTGCGGAAGTTGCGCGCAAACGATCGACGATTTAATTTCGCACAGATCGGATGTCCACGGCAGTAAATTTGATTGTAAAGAGTGTGGACAGGTTGTTCATAGTTCAAAAGCTTTAATGATTCACTGTCGCGCTCATCAAAGCTTAAAACCTTTTGTATGCGATCAGTGCGGTCGCAGTTATTCGCAAACTTCGCATCTGTGGCAGCATATGCGTTTCCATCAAGgtATAAAACCATTTGCATGCCCGCACGAAGGATGTGAAGCGCGTTATACAATTCGGCCCGATTTGAAAGATCACATTCGCAAAGTGCATACTCGCGAGCGACCGTTTCGTTGTGCCGTTTGCGGAAAATGTTTTCTTACTGGATCAGTTTATTATCAACATCGTCTGATTCATAATAATGATCGAAGATACGGCTGTGACATGTGCGGTAAGAGGTTTTTCCGCGCCGACGCTCTGAACAACCACCGCCGTATTCACACCGACGAGAGACCGTTCCCGTGTCCGGTTTGTGGTCGCGAGTTTCGTCAAAAGGGCGATCGCAACAAACACCATCGCACCCAGCATCCTGCTGAATTGGCCCAATCTTTGGTGGCCAATACGTCAATAATATCAATttga
Protein Sequence: MDENAHLQGISLVDDNQSDILSQALVSTEEVKLSDSPVQWGYVIDTDSKLNLKMQSSPATITLIKIGGIEDLNPLNYTTHIAPPLNQIHRVVIDDEILNDQLPEMIVPSKIKDKSKKKYMPPLPQTEPAVICQNCDASFATKYYYQRHQCEFNASKVMLKSELPKRNIEKPKTKHECDICHKSFMTEHNLDRHRLSHGEKKPFICQNCGKGFVLESRLNTHIENHCKMTSGEKKRFYRSDLSVWECWNCKLPNDNQENKENDPKTTFPHSTATSKPTQESVKIVKILGENNYSTTTENFILNNFDANFEKAMSGIDLFSQPEPGFYKEAASTKNVRIVNDNNNMKIDHTFVKIRVEQLFQCEYCNRTYAKKDILKDHQNSHTVNKNYLCMFCEESFESYTNAIVHWQHKCDNKWNVFCLPKIVVCKFCDKGFKSHELLYAHKYKLRHFVPKVCKDGRNESSKQSNRPDESDFNSKRIEGTERGSSEVKKDVIYSTINISFDDNTRIRTLTIDDLTKLSLDMPDNNKSVVDISNGEINVSDINIQDILMDSNNTSVKTDNGCENESTNQPINDYEYNEIDKFLNEIERKVLDNKGLCDRAADNDNNMTSIKMESIEILDDMVQDEINLEEPFKKRLRRSLRKCNQTENVEKENVAEKDENFEKNKRGRKKSSEFFKFPLPDINKRLTRNSLKNLVEKENIVRNENLEDETIEKKKKPEETELTVNIKLEHDDDKSDKTDEDTDSTTVTVVTPVPSKRGRKPKPKLNMDPPVINECADGFRFQCEKCGSCAQTIDDLISHRSDVHGSKFDCKECGQVVHSSKALMIHCRAHQSLKPFVCDQCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFRCAVCGKCFLTGSVYYQHRLIHNNDRRYGCDMCGKRFFRADALNNHRRIHTDERPFPCPVCGREFRQKGDRNKHHRTQHPAELAQSLVANTSIISI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01511470;
90% Identity: iTF_01511470;
80% Identity: -