Basic Information

Gene Symbol
-
Assembly
GCA_963575645.1
Location
OY754469.1:9809503-9810429[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0046 0.095 13.7 1.5 1 23 31 53 31 53 0.92
2 10 2.2e-05 0.00045 21.0 1.1 1 23 59 82 59 82 0.90
3 10 0.0027 0.055 14.5 1.2 2 23 88 109 87 109 0.96
4 10 0.043 0.89 10.7 3.9 2 23 115 137 114 137 0.94
5 10 1.5e-05 0.0003 21.6 4.2 1 23 141 164 141 164 0.97
6 10 1.7e-05 0.00035 21.4 0.5 2 23 174 195 173 195 0.96
7 10 6.2e-06 0.00013 22.8 0.2 1 23 198 220 198 220 0.98
8 10 5.9e-06 0.00012 22.8 1.9 2 23 227 248 226 248 0.96
9 10 2.1e-06 4.4e-05 24.2 1.9 1 23 254 276 254 276 0.98
10 10 7.8e-05 0.0016 19.3 0.3 1 23 282 305 282 305 0.97

Sequence Information

Coding Sequence
atgaaacaagaaattCAAGAAGATGGGAATGAAAATCCTGCTTTGACGGACGAAATAAAAACTGCTGGTTACATTAAAGTGCCGTACGGGTATCGCTGTAAGCAGTGCGGAAAAGAGTTTCAGTACAAATGGGGTTGGATTAGACACAATTTTAATCACAATAAATTACGTCCTTTCGTCTGCAAGGTATGCGGAAAATCGTTTAAAACTAGATACGATATGAAAATCCACAATGTTAAAATGCATCGAGACATTTATTTGATTTGCAGTATTTGCAACGAAATATGCGACAGCAAAGAATCGCTGAGATTGCATCAAAGCAAGCACGGCGATGTATTGTTGAAATGTCGATTTTGTTGCGAAAAGTTCAGAACGAAAATCGAGCTGAAAAAACACATGAATGGTGATCATAAAGGCGCATATGATTGTGATAAATGTCACAAGTCGTTTTTCAACAAAGGAAATTTAAAAGTACACTATAAAAAAGTACACGATAACGGTTATTCCGTACCGAAACTGGAGTGCGATAAATGCGGCAAAGCGTACAAATCGCGTCAAAAATTGAACGTGCATTTACGGGGCCACGAAGGGTTCACTTGTGACGTTTGCGGGAAAGTTTTGACGCGCAAGTGGAGTCTGGAACAACACTTGTTGTCTCATAGCGGCGAGAAACCGTTGAACTGTGAAATGTGCGGCAAAAGGTTTACAAAGACGTTTAATTTGACGCTGCACCTAAGAACACAtaccggagagaaaccgtacgagTGCAAGCAGTGCGGAAAGCGATTTTCGACCCGTACTTCGTACGTCGTTCACATCAGATACCATACCGGGGAGCGACCGTATCCTTGTGAGCTTTGCGATAAAGCGTTTGTGACCAGAACCCAAATGATGTCGCATGTACAACGAAATCATAACAGAAGATGA
Protein Sequence
MKQEIQEDGNENPALTDEIKTAGYIKVPYGYRCKQCGKEFQYKWGWIRHNFNHNKLRPFVCKVCGKSFKTRYDMKIHNVKMHRDIYLICSICNEICDSKESLRLHQSKHGDVLLKCRFCCEKFRTKIELKKHMNGDHKGAYDCDKCHKSFFNKGNLKVHYKKVHDNGYSVPKLECDKCGKAYKSRQKLNVHLRGHEGFTCDVCGKVLTRKWSLEQHLLSHSGEKPLNCEMCGKRFTKTFNLTLHLRTHTGEKPYECKQCGKRFSTRTSYVVHIRYHTGERPYPCELCDKAFVTRTQMMSHVQRNHNRR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01511299;
90% Identity
-
80% Identity
-